Human oral microbiome database
Skin microbiome (Pubmed)
The New Science of Metagenomics - (Free NCBI textbook)
A BBC podcast on the microbiome
Powered by The microbiome represents diverse viral, bacterial fungal and other species that live on and within us. They are a part of us and we are a part of this complex ecosystem. Their proteins bind to ours, and their metabolism influences ours and vice versa. The gut microbiome seems to be divided into three major enterotypes Arumugam et al, 2011. A well balanced microbiome may keep us healthy, while imbalances may be a factor in causing disease. Certain diseases can be affected by manipulating the microbiome and some microbiome effects are catalogued here.
Viruses , bacteria and other pathogens are risk factors in many diseases, and in several cases can cause disease.These are summarised for several diseases. Unlike genes, pathogens can be attacked and sometimes eliminated.
The Pubmed icons click to the term + microbiome and some examples are given: Other Pubmed searches (e.g. probiotic) are programmed: Summaries of the searches are provided.......................in progress
PANDAS Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
Control of antiviral immunity by pattern recognition and the microbiome. Pang and Iwasaki 2011
Alzheimer's disease Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Claesson et al, 2011
Atherosclerosis Human oral, gut, and plaque microbiota in patients with atherosclerosis. Koren et al, 2011
Autism See also:- Normal gut microbiota modulates brain development and behavior Heijtza et al, 2011 in relation to neurodevelopmental disorders
Cystic fibrosis Microbiome refs
Diabetes Type 1 The intestinal microbiome: relationship to type 1 diabetes. Neu et al, 2011
Type 2 Diabetes Microbiome references
Diseases caused by bacteria viruses and pathogens ( apart from their immediate acute effects e.g. cold sores, flu, common cold)
Bacteria use some of the same metabolites as us and infection can markedly affect the levels of important compounds such as cholesterol, glutathione, tryptophan, methionine S-adenosyl-methionine, and homocysteine. Levels of these metabolites are modified in many human diseases.
One carbon metabolism and the transsulfuration pathway By Michael C Reed , Rachel L Thomas , Jovana Pavisic , S Jill James , Cornelia M Ulrich and H Frederik Nijhout (A mathematical model of glutathione metabolism) [CC-BY-2.0 (www.creativecommons.org/licenses/by/2.0)], via Wikimedia Commons
Tryptophan and madness from Adonis Sfera, MD The fates of trytophan, kynurenines and quinolinate and the immune system
Diseases: Viruses, bacteria, other pathogens and risk factors implicated in:-
You and Your Ten Thousand Trillion Microbes
From YouTube: For every human cell in your body, there are hundreds or thousands of bacterial cells. So who is hosting whom? Even though our on-board microbial hordes—known also as our microbiome—sometimes threaten and deprive us of our health and our lives, they are central to our survival and our daily well being.
A discussion brought to you by the DC Science Writers Association and the USA Science and Engineering Festival filmed on Tuesday, April 17 at Busboys and Poets on 5th and K Sts., NW, Washington, D.C., that might convince you to love your microbial partners in life, albeit with a healthy respect for the ways they can become dangerous. Leading the discussion is microbiologist Liliana Losada of the J. Craig Venter Institute, an independent research laboratory in Rockville, Md., that has been greatly expanding our fundamental knowledge of the microbes in our world; and Alison O'Brien, former president of the American Society of Microbiology, professor of microbiology and immunology at the Uniformed Services University of the Health Sciences, and an expert in the gut bacterium known as E. coli, a major player in human health, basic science and biotechnology.
Medicine news headlines provided courtesy of Medical News Today.
Last update: January 28, 2014