Host-pathogen Interactome Databases

Host pathogen interactomes: PolygenicPathways

Wikipedia links Interactomes KEGG pathways


Interactome KEGG pathways
Borrelia Burgdorferi Interactome KEGG pathways
Candida albicans Interactome KEGG pathways
Chlamydia Pneumoniae Interactome

KEGG pathways

Cryptococcus Neoformans Interactome KEGG pathways
Ebola virus Interactome KEGG pathways
Epstein-Barr virus


KEGG pathways
Helicobacter pylori Interactome KEGG pathways
Hepatitis C virus Interactome KEGG pathways
Herpes simplex (HSV-1) VIPR Interactome KEGG pathways
HERV-W Interactome KEGG pathways

NCBI HIV-1, Human Protein Interaction Database

KEGG pathways
Human cytomegalovirus Interactome KEGG pathways
Influenza A virus Interactome KEGG pathways
Porphyromonas Gingivalis Interactome KEGG pathways
Toxoplasma Gondii Interactome KEGG pathways
Trypanosoma Cruzi Interactome KEGG pathways
DenHunt Dengue virus interactome
Interactome Databases References
HCVPro HCVpro: hepatitis C virus protein interaction database Kwofie et al, 2011.
Virus Human Interactome Network Map VirHostome database From the Dana Farber Cancer Institute and Harvard medical school. "Host interactome and transcriptome networks induced by individual gene products encoded by members of four functionally related, yet biologically distinct, families of DNA tumor viruses: several polyomaviruses (PyV), simian virus 40 (SV40) in particular; six classes of human papillomaviruses (HPV), high-risk (for carcinogenesis) mucosal HPV16 and HPV18, low risk mucosal HPV6b and HPV11, and cutaneous HPV5 and HPV8; Epstein-Barr Virus (EBV); and Adenovirus 5 (Ad5)."
VirHostNet University of Lyon VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks Navratil et al, 2009.
VirusMentha VirusMentha: a new resource for virus-host protein interactions Calderone et al, 2015
VirusMint University of Rome (stored at Harmonizome ) VirusMINT: a viral protein interaction database.Chatr-aryamontri et al, 2009
VIPR Virus pathogen Resource : ViPR: an open bioinformatics database and analysis resource for virology research. Pickett et al, 2012
ViralZone ViralZone is a SIB Swiss Institute of Bioinformatics web-resource for all viral genus and families, providing general molecular and epidemiological information, along with virion and genome figures. Each virus or family page gives an easy access to UniProtKB/Swiss-Prot viral protein entries.
Pathogen interaction Gateway Protein/Protein interactions (PPI's ) from a wide range of bacteria and viruses and numerous invertebrate and vertebrate hosts from The Pathogen Portal developed and maintained by the CyberInfrastructure Division at the Virginia Bioinformatics Institute at Virginia Tech.
Vita Department of Biological Science and Technology, Institute of Bioinformatics
National Chiao Tung University,Hsinchu, Taiwan
ViTa is a database which collects virus data from miRBase and ICTV, VirGne, VBRC.., etc, including known miRNAs on virus and supporting predicted host miRNA targets by miRanda and TargetScan. ViTa also provide effective annotations,
including human miRNA expression, virus infected tissues, annotation of virus and comparisons. Additionally, a multiple functions and graphical web interface are designed and implemented to help users to investigate the microRNA
roles in viral existence. ViTa is developed by Bidlab(2005)
FluMap A Comprehensive map of Influenza A virus replication cycle Matsuoka et al, .BMC Systems Biology 2013, 7:97
NCBI HIV-1, Human Protein Interaction Database
  • Human immunodeficiency virus type 1, human protein interaction database at NCBI Fu et al, 2009
  • Cataloguing the HIV-1 Human Protein Interaction Network.
    Ptak et al, 2008,
  • HIV-host interactions: a map of viral perturbation of the host system Pinney et al, 2009
  Omics tools Host pathogen interactions
  EHFPI Database of Essential Host Factors for Pathogenic Infection Liu et al, 2015
  vhfRNAi: vhfRNAi: a web-platform for analysis of host genes involved in viral infections discovered by genome wide RNAi screens Thakur et al, 2017


Susceptibility genes are enriched in those of the herpes simplex (HSV-1) / host interactome in psychiatric and neurological disorders. Pathogens and disease 2013

Toxoplasmosis and polygenic disease susceptibility genes: Extensive T.Gondii host/pathogen interactome enrichment
in nine psychiatric or neurological disorders J. Pathogens, 2013

Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease Journal of Alzheimer's disease reports 2017

The Porphyromonas gingivalis/host interactome shows enrichment in GWASdb genes related to Alzheimer’s disease, diabetes and cardiovascular diseases Carter, France, Crean & Singhrao, 2017

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