Alzheimer's risk factors

Add to Mendeley

Site search Loading

  Site search

Environmental and other risk factors affecting Alzheimer's disease .......... Alzheimer's disease associations and societies worldwide

An interesting article "Can Alzheimer's disease be prevented" can be found at the National Institute on ageing website. It is not yet possible to cure Alzheimer's disease. However there is reasonable evidence to suggest that a healthy lifesyle, "sensible" dietary regimes and avoidance of excess (smoking and alcohol) can delay the onset of the disease. This really simplifies to " a healthy mind in a healthy body" Mens sana in corpore sano. These lifestyle issues are similar, if not identical to the problems of heart disease, atherosclerosis and stroke. Advice on these matters can also be found at the American Heart Association and at the Alzheimer's Association websites and at PredictAD or Food For The Brain at Alzheimer's Disease International and at Dementia Today

Ongoing clinical trails, worldwide, can be interrogated at ClinicalTrials.Gov a service of the US National Institutes of Health

  • Papers based on this site: Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis Neurochem Int ,2006
  • Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.Neurochem Int, 2007
  • Alzheimer's disease as an autoimmune and potentially curable disorder ?NaturePrecedings and Website (with translation and enhanced links)
  • APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle. Neuroscience Letters, 2010
  • Alzheimer's disease plaques and tangles: Cemeteries of an immune battle with herpes simplex Neurochem.Int, 2010 Tangles description from TauRX therapeutics
  • Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner Int .J.Alz Dis 2010
  • The fox and the rabbits, environmental variables and population genetics.1: Replication problems in association studies and the untapped power of GWAS. 2: Vitamin A deficiency, herpes simplex reactivation and other causes of Alzheimer’s disease ISRN Neurology, 2011
  • Alzheimer’s disease: APP, gamma secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1 and MS4A2, and their relationships with herpes simplex , C.Pneumoniae, other suspect pathogens and the immune system: Int.J.Alz.Dis, 2011
  • Toxoplasmosis and polygenic diseases: Extensive T.Gondii host/pathogen interactome enrichment in nine psychiatric or neurological disorders J.Pathogens, 2012
  • Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders Pathogens and disease 2013.
  • Kegg pathway analysis of over 400 susceptibility genes: Herpes simplex related genes are included.
 

Infectious agents Alzforum Herpes/Alzheimers webinar

Dietary and lifestyle factors

Hormonal effects

Autoantibodies present in Alzheimer's disease sera

Epidemiological studies

  • Alzheimer's disease is more common in women Schmidt et al, 2008
  • In the USA, Alzheimer's disease is more common in Afro-Americans and Hispanics than in European Americans Alzheimer's association 2010
  • Illiteracy is associated with a higher risk of AD an effect increasing with age Lee et al, 2008.
  • Low educational attainment is associated with a higher risk of Alzheimer's disease Letenneur et al, 1999
  • Being a farmer may increase the risk of dementia with parkinsonism in women Helmer et al, 2001
  • Having fathers as coal miners hs been associated with Alzheimer's disease Whalley et al, 1995
  • An association between goods production, manual work and Alzheimer's disease was found in Korea Qiu et al, 1993
  • Birth in a rural area has been asociated with Alzheimer's disease Jean et al, 1996
  • Long-term occupational exposure to a higher Extremely-low-frequency magnetic field level may increase the risk of Alzheimer's disease and dementia in men Qiu et al, 2004
  • In the Nun study, despite Alzheimer's disease pathology (plaques and tangles) cognitive function can be normal Snowdon, 1997 Nun study at the University of Minnesota
  • Cognitive decline leading to dementia can be observed in Bipolar disorder Lebert et al, 2008
  • Early dementia is often diagnosed as some form of psychiatric disease (depression, schizophrenia, bipolar etc.) and these (or the drugs used to treat them ?) might also be independent risk factors for the subsequent development of neurodegenerative diseases Wooley et al, 2011
  • Death of a spouse without remarriage can increase the risk of dementia Medscape

Protective Drugs, Diets Vitamins and Vaccines (Clinical Trials)

Biomarkers

  • A blood RNA signature highlights genes involved in pathways associated with macrophages and lymphocytes: TGF-beta signaling, oxidative stress, innate immunity and inflammation, cholesterol homeostasis, and lipid-raft perturbation pathways were implicated Fehlbaum-Beurdeley et al, 2010
  • 10 autoantibody biomarkers can differentiate Alzheimer's disease sera Nagele et al, 2011
  • An immunosignature derived from thousands or randomly synthesised peptides is able to accurately discriminate Alzheimer's disease Restrepo et al, 2011
  • An algorithm derived from a biomarker risk score, clinical lab (glucose, triglycerides, total cholesterol, homocysteine), and demographic (age, gender, education, APOE*E4 status) data O'Bryant et al, 2011.
  • Decreased plasma desmosterol levels Sato et al, 2011 and reduced desmosterol/cholesterol ratio Sato et al, 2012
  • Increased plasma levels of annexin ANXA5 Sohma et al, 2013
  • Higher serum phenylalanine concentrations related to immune activation observed in a subgroup of AD patients Wissmann et al, 2013.
  • High levels of beta-defensin DEFB1 (anti-microbial peptide ) in the AD brain Williams et al, 2013
  • Higher tryptophan 2,3 dioxygenase (TDO) and indoleamine 2,3 dioxygenase 1 (IDO1) immunoreactivity in Alzheimer's disease hippocampus where TDO co-localizes with quinolinic acid, neurofibrillary tangles, tau and amyloid deposits Wu et al, 2013 The IDO1 reponse is a common defense mechanism against pathogens that depend upon the host supply of tryptophan, and is also involved in antiviral effects) Reviewed in Murakami et al, 2013

 

 

 

Loading...

 

 

 

 

View Stats
 

Last update: June 17, 2014