Alzheimer's Pathways

hsa01100 Metabolic pathways - Homo sapiens (human) (78)

cpd:C00018 Pyridoxal phosphate cpd:C00019 S-Adenosyl-L-methionine cpd:C00025 L-Glutamate cpd:C00031 D-Glucose cpd:C00051 Glutathione cpd:C00072 Ascorbate cpd:C00078 L-Tryptophan cpd:C00155 L-Homocysteine cpd:C00187 Cholesterol cpd:C00250 Pyridoxal cpd:C00253 Nicotinate cpd:C00376 Retinal cpd:C00378 Thiamine cpd:C00422 Triacylglycerol cpd:C00473 Retinol cpd:C00504 Folate cpd:C00534 Pyridoxamine cpd:C00951 Estradiol-17beta cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid cpd:C02094 beta-Carotene cpd:C02477 alpha-Tocopherol cpd:C03722 Quinolinate cpd:C05441 Vitamin D2 cpd:C05443 Vitamin D3 cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid hsa:10 NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5) hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-) hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast) hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) hsa:1718 DHCR24; 24-dehydrocholesterol reductase (EC:1.3.1.72) hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10) hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3) hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:26330 GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (EC:1.2.1.12) hsa:27034 ACAD8; acyl-CoA dehydrogenase family, member 8 hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146) hsa:349565 NMNAT3; nicotinamide nucleotide adenylyltransferase 3 (EC:2.7.7.1 2.7.7.18) hsa:3990 LIPC; lipase, hepatic (EC:3.1.1.3) hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4508 ATP6; ATP synthase F0 subunit 6 hsa:4509 ATP8; ATP synthase F0 subunit 8 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I) hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I) hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I) hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I) hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I) hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I) hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) hsa:5409 PNMT; phenylethanolamine N-methyltransferase (EC:2.1.1.28) hsa:5444 PON1; paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) hsa:5445 PON2; paraoxonase 2 (EC:3.1.1.2 3.1.1.81) hsa:5446 PON3; paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:5832 ALDH18A1; aldehyde dehydrogenase 18 family, member A1 (EC:1.2.1.41 2.7.2.11) hsa:64409 WBSCR17; Williams-Beuren syndrome chromosome region 17 (EC:2.4.1.41) hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22) hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)

hsa05010 Alzheimer's disease - Homo sapiens (human) (31)

hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22) hsa:23385 NCSTN; nicastrin hsa:23621 BACE1; beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) hsa:25825 BACE2; beta-site APP-cleaving enzyme 2 (EC:3.4.23.45) hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:322 APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) hsa:3416 IDE; insulin-degrading enzyme (EC:3.4.24.56) hsa:348 APOE; apolipoprotein E hsa:351 APP; amyloid beta (A4) precursor protein hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3553 IL1B; interleukin 1, beta hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34) hsa:4035 LRP1; low density lipoprotein receptor-related protein 1 hsa:4137 MAPT; microtubule-associated protein tau hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11) hsa:4508 ATP6; ATP synthase F0 subunit 6 hsa:4509 ATP8; ATP synthase F0 subunit 8 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans) hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4) hsa:6622 SNCA; synuclein, alpha (non A4 component of amyloid precursor) hsa:7124 TNF; tumor necrosis factor hsa:8851 CDK5R1; cyclin-dependent kinase 5, regulatory subunit 1 (p35) APH1B belongs in this pathway APBA1 belongs here APBB2 belongs here APBB3 belongs here

hsa05200 Pathways in cancer - Homo sapiens (human) (26)

cpd:C00187 Cholesterol cpd:C00951 Estradiol-17beta hsa:1612 DAPK1; death-associated protein kinase 1 (EC:2.7.11.1) hsa:2246 FGF1; fibroblast growth factor 1 (acidic) hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:367 AR; androgen receptor hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:613 BCR; breakpoint cluster region (EC:2.7.11.1) hsa:6256 RXRA; retinoid X receptor, alpha hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:7186 TRAF2; TNF receptor-associated factor 2 hsa:7422 VEGFA; vascular endothelial growth factor A hsa:861 RUNX1; runt-related transcription factor 1

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (21)

cpd:C00018 Pyridoxal phosphate cpd:C00072 Ascorbate cpd:C00187 Cholesterol cpd:C00250 Pyridoxal cpd:C00376 Retinal cpd:C00378 Thiamine cpd:C00422 Triacylglycerol cpd:C00473 Retinol cpd:C00504 Folate cpd:C00534 Pyridoxamine cpd:C02075 Retinyl ester cpd:C02094 beta-Carotene cpd:C02477 alpha-Tocopherol cpd:C02530 Cholesterol ester cpd:C05377 Menadione cpd:C05443 Vitamin D3 cpd:C05776 Vitamin B12 CUBN belongs to this pathway (acts as a receptor for intrinsic factor-vitamin B12 complexes) hsa:335 APOA1; apolipoprotein A-I hsa:337 APOA4; apolipoprotein A-IV hsa:8029 CUBN; cubilin (intrinsic factor-cobalamin receptor) hsa:9227 LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (EC:2.3.1.135)

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (19)

cpd:C05443 Vitamin D3 hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1) hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:4314 MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7422 VEGFA; vascular endothelial growth factor A hsa:942 CD86; CD86 molecule IL1RN belongs in this pathway

hsa04010 MAPK signaling pathway - Homo sapiens (human) (18)

hsa:2246 FGF1; fibroblast growth factor 1 (acidic) hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:4137 MAPT; microtubule-associated protein tau hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:627 BDNF; brain-derived neurotrophic factor hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53 hsa:7186 TRAF2; TNF receptor-associated factor 2 hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit hsa:929 CD14; CD14 molecule hsa:9479 MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1

hsa05164 Influenza A - Homo sapiens (human) (18)

hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7919 DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (EC:3.6.4.13) hsa:90865 IL33; interleukin 33

hsa05152 Tuberculosis - Homo sapiens (human) (17)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1509 CTSD; cathepsin D (EC:3.4.23.5) hsa:1520 CTSS; cathepsin S (EC:3.4.22.27) hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3586 IL10; interleukin 10 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor hsa:929 CD14; CD14 molecule

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (17)

hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3586 IL10; interleukin 10 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor

hsa05012 Parkinson's disease - Homo sapiens (human) (16)

hsa:120892 LRRK2; leucine-rich repeat kinase 2 (EC:2.7.11.1) hsa:27429 HTRA2; HtrA serine peptidase 2 (EC:3.4.21.108) hsa:4508 ATP6; ATP synthase F0 subunit 6 hsa:4509 ATP8; ATP synthase F0 subunit 8 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I) hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I) hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I) hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I) hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I) hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I) hsa:6622 SNCA; synuclein, alpha (non A4 component of amyloid precursor) hsa:7345 UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12)

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (14)

cpd:C00025 L-Glutamate hsa:10886 NPFFR2; neuropeptide FF receptor 2 hsa:1136 CHRNA3; cholinergic receptor, nicotinic, alpha 3 hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 hsa:1141 CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal) hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:3362 HTR6; 5-hydroxytryptamine (serotonin) receptor 6 hsa:3363 HTR7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) hsa:3973 LHCGR; luteinizing hormone/choriogonadotropin receptor hsa:4158 MC2R; melanocortin 2 receptor (adrenocorticotropic hormone) also SLC6A4

hsa05144 Malaria - Homo sapiens (human) (14)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3586 IL10; interleukin 10 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:4035 LRP1; low density lipoprotein receptor-related protein 1 hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa05016 Huntington's disease - Homo sapiens (human) (14)

cpd:C00025 L-Glutamate hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9) hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:4508 ATP6; ATP synthase F0 subunit 6 hsa:4509 ATP8; ATP synthase F0 subunit 8 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:627 BDNF; brain-derived neurotrophic factor hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1) hsa:7019 TFAM; transcription factor A, mitochondrial hsa:7157 TP53; tumor protein p53

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (14)

hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-) hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast) hsa:4508 ATP6; ATP synthase F0 subunit 6 hsa:4509 ATP8; ATP synthase F0 subunit 8 hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:4535 ND1; NADH dehydrogenase, subunit 1 (complex I) hsa:4537 ND3; NADH dehydrogenase, subunit 3 (complex I) hsa:4538 ND4; NADH dehydrogenase, subunit 4 (complex I) hsa:4539 ND4L; NADH dehydrogenase, subunit 4L (complex I) hsa:4540 ND5; NADH dehydrogenase, subunit 5 (complex I) hsa:4541 ND6; NADH dehydrogenase, subunit 6 (complex I)

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (13)

hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1) hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta IL1RN belongs in this pathway hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3586 IL10; interleukin 10 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7422 VEGFA; vascular endothelial growth factor A

hsa03320 PPAR signaling pathway - Homo sapiens (human) (13)

hsa:116519 APOA5; apolipoprotein A-V hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10) hsa:335 APOA1; apolipoprotein A-I hsa:345 APOC3; apolipoprotein C-III hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34) hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) hsa:5360 PLTP; phospholipid transfer protein hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:6256 RXRA; retinoid X receptor, alpha hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa05146 Amoebiasis - Homo sapiens (human) (13)

hsa:1301 COL11A1; collagen, type XI, alpha 1 hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3586 IL10; interleukin 10 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:929 CD14; CD14 molecule

hsa05162 Measles - Homo sapiens (human) (12)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73

hsa05160 Hepatitis C - Homo sapiens (human) (12)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3576 IL8; interleukin 8 hsa:3949 LDLR; low density lipoprotein receptor hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:6256 RXRA; retinoid X receptor, alpha hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53 hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (11)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1) hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11) hsa:7124 TNF; tumor necrosis factor hsa:929 CD14; CD14 molecule hsa:948 CD36; CD36 molecule (thrombospondin receptor) CD2AP belongs in this pathway (associates with CD2 )

hsa05166 HTLV-I infection - Homo sapiens (human) (11)

hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53

hsa05145 Toxoplasmosis - Homo sapiens (human) (11)

hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:3586 IL10; interleukin 10 hsa:3949 LDLR; low density lipoprotein receptor hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor

hsa05140 Leishmaniasis - Homo sapiens (human) (11)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3586 IL10; interleukin 10 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor

hsa05133 Pertussis - Homo sapiens (human) (11)

cpd:C00253 Nicotinate hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3586 IL10; interleukin 10 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:929 CD14; CD14 molecule

hsa02010 ABC transporters - Homo sapiens (human) (11)

cpd:C00025 L-Glutamate cpd:C00031 D-Glucose cpd:C00051 Glutathione cpd:C00378 Thiamine cpd:C05776 Vitamin B12 hsa:10347 ABCA7; ATP-binding cassette, sub-family A (ABC1), member 7 hsa:1244 ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2 hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1 hsa:20 ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2 hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:9619 ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1

hsa04145 Phagosome - Homo sapiens (human) (11)

hsa:1520 CTSS; cathepsin S (EC:3.4.22.27) hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:4353 MPO; myeloperoxidase (EC:1.11.1.7) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4973 OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:929 CD14; CD14 molecule hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (11)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4) hsa:627 BDNF; brain-derived neurotrophic factor hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73 hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

hsa04380 Osteoclast differentiation - Homo sapiens (human) (10)

hsa:1435 CSF1; colony stimulating factor 1 (macrophage) (EC:2.7.10.1) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7186 TRAF2; TNF receptor-associated factor 2 hsa:9846 GAB2; GRB2-associated binding protein 2

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (10)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:2 A2M; alpha-2-macroglobulin hsa:2162 F13A1; coagulation factor XIII, A1 polypeptide (EC:2.3.2.13) hsa:3075 CFH; complement factor H hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:5265 SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 hsa:5327 PLAT; plasminogen activator, tissue (EC:3.4.21.68) hsa:5328 PLAU; plasminogen activator, urokinase (EC:3.4.21.73) hsa:5345 SERPINF2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 hsa:720 C4A; complement component 4A (Rodgers blood group) CRP belongs here (binds to CFH) CLU clusterin belongs here (binds to C7, C8 and C9)

hsa04144 Endocytosis - Homo sapiens (human) (10)

cpd:C00504 Folate hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:3949 LDLR; low density lipoprotein receptor hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa BIN1 bridging integrator 1 interacts with dynamin and belongs in this pathway PICALM phosphatidylinositol binding clathrin assembly protein belongs in this pathway EPHA1 binds to SMURF2

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (10)

hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:7097 TLR2; toll-like receptor 2 hsa:7099 TLR4; toll-like receptor 4 hsa:7124 TNF; tumor necrosis factor hsa:929 CD14; CD14 molecule hsa:942 CD86; CD86 molecule

hsa04020 Calcium signaling pathway - Homo sapiens (human) (10)

hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:3362 HTR6; 5-hydroxytryptamine (serotonin) receptor 6 hsa:3363 HTR7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) hsa:3973 LHCGR; luteinizing hormone/choriogonadotropin receptor hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)

hsa04976 Bile secretion - Homo sapiens (human) (9)

cpd:C00031 D-Glucose cpd:C00051 Glutathione cpd:C00187 Cholesterol cpd:C00504 Folate cpd:C02530 Cholesterol ester hsa:1244 ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2 hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) hsa:3949 LDLR; low density lipoprotein receptor hsa:6256 RXRA; retinoid X receptor, alpha

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (9)

cpd:C00019 S-Adenosyl-L-methionine cpd:C00025 L-Glutamate hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) hsa:5009 OTC; ornithine carbamoyltransferase (EC:2.1.3.3) hsa:5832 ALDH18A1; aldehyde dehydrogenase 18 family, member A1 (EC:1.2.1.41 2.7.2.11)

hsa05143 African trypanosomiasis - Homo sapiens (human) (9)

cpd:C00078 L-Tryptophan hsa:335 APOA1; apolipoprotein A-I hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3586 IL10; interleukin 10 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:7124 TNF; tumor necrosis factor

hsa04725 Cholinergic synapse - Homo sapiens (human) (9)

hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6) hsa:1136 CHRNA3; cholinergic receptor, nicotinic, alpha 3 hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 hsa:1141 CHRNB2; cholinergic receptor, nicotinic, beta 2 (neuronal) hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:3763 KCNJ6; potassium inwardly-rectifying channel, subfamily J, member 6 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa00480 Glutathione metabolism - Homo sapiens (human) (9)

cpd:C00025 L-Glutamate cpd:C00051 Glutathione cpd:C00072 Ascorbate hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9) hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18) hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18)

hsa04975 Fat digestion and absorption - Homo sapiens (human) (9)

cpd:C00187 Cholesterol cpd:C00422 Triacylglycerol cpd:C02530 Cholesterol ester hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51) hsa:19 ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1 hsa:335 APOA1; apolipoprotein A-I hsa:337 APOA4; apolipoprotein A-IV hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) (9)

cpd:C00025 L-Glutamate cpd:C00078 L-Tryptophan hsa:4563 TRNG; tRNA-Gly hsa:4564 TRNH; tRNA-His hsa:4568 TRNL2; tRNA-Leu hsa:4572 TRNQ; tRNA-Gln hsa:4573 TRNR; tRNA-Arg hsa:4575 TRNS2; tRNA-Ser hsa:4576 TRNT; tRNA-Thr

hsa04142 Lysosome - Homo sapiens (human) (8)

hsa:10577 NPC2; Niemann-Pick disease, type C2 hsa:1509 CTSD; cathepsin D (EC:3.4.23.5) hsa:1520 CTSS; cathepsin S (EC:3.4.22.27) hsa:20 ABCA2; ATP-binding cassette, sub-family A (ABC1), member 2 hsa:3988 LIPA; lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13) hsa:410 ARSA; arylsulfatase A (EC:3.1.6.8) hsa:411 ARSB; arylsulfatase B (EC:3.1.6.12) hsa:4864 NPC1; Niemann-Pick disease, type C1

hsa04210 Apoptosis - Homo sapiens (human) (8)

hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53 hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (8)

hsa:22900 CARD8; caspase recruitment domain family, member 8 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3576 IL8; interleukin 8 hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:4210 MEFV; Mediterranean fever hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:7124 TNF; tumor necrosis factor

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (8)

hsa:29979 UBQLN1; ubiquilin 1 hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:4780 NFE2L2; nuclear factor (erythroid-derived 2)-like 2 hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:6400 SEL1L; sel-1 suppressor of lin-12-like (C. elegans) hsa:7186 TRAF2; TNF receptor-associated factor 2 hsa:7415 VCP; valosin containing protein

hsa05215 Prostate cancer - Homo sapiens (human) (8)

cpd:C00951 Estradiol-17beta hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:367 AR; androgen receptor hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7157 TP53; tumor protein p53

hsa04510 Focal adhesion - Homo sapiens (human) (8)

hsa:1301 COL11A1; collagen, type XI, alpha 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5649 RELN; reelin hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7422 VEGFA; vascular endothelial growth factor A hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa

hsa05332 Graft-versus-host disease - Homo sapiens (human) (8)

hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor hsa:942 CD86; CD86 molecule

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (8)

hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7124 TNF; tumor necrosis factor

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (7)

hsa:2206 MS4A2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7124 TNF; tumor necrosis factor hsa:9846 GAB2; GRB2-associated binding protein 2 Other MS4 genes bel;ong in this pathway

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (7)

cpd:C00025 L-Glutamate hsa:10452 TOMM40; translocase of outer mitochondrial membrane 40 homolog (yeast) hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9) hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:7124 TNF; tumor necrosis factor hsa:7157 TP53; tumor protein p53

hsa04612 Antigen processing and presentation - Homo sapiens (human) (7)

hsa:1520 CTSS; cathepsin S (EC:3.4.22.27) hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:7124 TNF; tumor necrosis factor

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (7)

hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3576 IL8; interleukin 8 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (7)

hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:7124 TNF; tumor necrosis factor hsa:942 CD86; CD86 molecule

hsa04910 Insulin signaling pathway - Homo sapiens (human) (7)

cpd:C00031 D-Glucose hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5506 PPP1R3A; protein phosphatase 1, regulatory (inhibitor) subunit 3A (EC:3.1.3.16) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:6720 SREBF1; sterol regulatory element binding transcription factor 1

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (7)

hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3586 IL10; interleukin 10 hsa:6741 SSB; Sjogren syndrome antigen B (autoantigen La) hsa:7124 TNF; tumor necrosis factor hsa:720 C4A; complement component 4A (Rodgers blood group) hsa:942 CD86; CD86 molecule

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (7)

hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4000 LMNA; lamin A/C hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit

hsa05416 Viral myocarditis - Homo sapiens (human) (7)

hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:4626 MYH8; myosin, heavy chain 8, skeletal muscle, perinatal hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa hsa:8735 MYH13; myosin, heavy chain 13, skeletal muscle hsa:942 CD86; CD86 molecule

hsa05220 Chronic myeloid leukemia - Homo sapiens (human) (7)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:613 BCR; breakpoint cluster region (EC:2.7.11.1) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:861 RUNX1; runt-related transcription factor 1 hsa:9846 GAB2; GRB2-associated binding protein 2

hsa00100 Steroid biosynthesis - Homo sapiens (human) (7)

cpd:C00187 Cholesterol cpd:C02530 Cholesterol ester cpd:C05441 Vitamin D2 cpd:C05443 Vitamin D3 hsa:1718 DHCR24; 24-dehydrocholesterol reductase (EC:1.3.1.72) hsa:3988 LIPA; lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13) hsa:6646 SOAT1; sterol O-acyltransferase 1 (EC:2.3.1.26)

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (6)

cpd:C00031 D-Glucose hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:26330 GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (EC:1.2.1.12) hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa05330 Allograft rejection - Homo sapiens (human) (6)

hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor hsa:942 CD86; CD86 molecule

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (6)

hsa:3105 HLA-A; major histocompatibility complex, class I, A hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:4685 NCAM2; neural cell adhesion molecule 2 hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B) hsa:942 CD86; CD86 molecule CD2AP belongs in this pathway (associates with CD2 )

hsa04110 Cell cycle - Homo sapiens (human) (6)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5933 RBL1; retinoblastoma-like 1 (p107) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa05222 Small cell lung cancer - Homo sapiens (human) (6)

hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6256 RXRA; retinoid X receptor, alpha hsa:7157 TP53; tumor protein p53 hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (6)

hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18)

hsa05020 Prion diseases - Homo sapiens (human) (6)

hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3552 IL1A; interleukin 1, alpha hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4685 NCAM2; neural cell adhesion molecule 2 hsa:5621 PRNP; prion protein

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (6)

hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:4000 LMNA; lamin A/C hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (6)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3586 IL10; interleukin 10 hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7124 TNF; tumor necrosis factor

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (6)

hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32) hsa:5465 PPARA; peroxisome proliferator-activated receptor alpha hsa:6256 RXRA; retinoid X receptor, alpha hsa:7124 TNF; tumor necrosis factor hsa:7186 TRAF2; TNF receptor-associated factor 2 hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (6)

hsa:2944 GSTM1; glutathione S-transferase mu 1 (EC:2.5.1.18) hsa:2947 GSTM3; glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) hsa:2950 GSTP1; glutathione S-transferase pi 1 (EC:2.5.1.18) hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146) hsa:9446 GSTO1; glutathione S-transferase omega 1 (EC:2.5.1.18)

hsa04115 p53 signaling pathway - Homo sapiens (human) (6)

hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:355 FAS; Fas (TNF receptor superfamily, member 6) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:7157 TP53; tumor protein p53 hsa:7161 TP73; tumor protein p73 hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa04370 VEGF signaling pathway - Homo sapiens (human) (5)

hsa:4846 NOS3; nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04540 Gap junction - Homo sapiens (human) (5)

cpd:C00025 L-Glutamate hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa04310 Wnt signaling pathway - Homo sapiens (human) (5)

hsa:22943 DKK1; dickkopf homolog 1 (Xenopus laevis) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:4040 LRP6; low density lipoprotein receptor-related protein 6 hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:7157 TP53; tumor protein p53

hsa04978 Mineral absorption - Homo sapiens (human) (5)

cpd:C00031 D-Glucose cpd:C00078 L-Tryptophan hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3) hsa:7018 TF; transferrin hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa05320 Autoimmune thyroid disease - Homo sapiens (human) (5)

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (5)

hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:81030 ZBP1; Z-DNA binding protein 1 hsa:90865 IL33; interleukin 33

hsa04330 Notch signaling pathway - Homo sapiens (human) (5)

hsa:23385 NCSTN; nicastrin hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans) hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4)

hsa04360 Axon guidance - Homo sapiens (human) (5)

hsa:1020 CDK5; cyclin-dependent kinase 5 (EC:2.7.11.22) hsa:1808 DPYSL2; dihydropyrimidinase-like 2 hsa:1946 EFNA5; ephrin-A5 hsa:2041 EPHA1; EPH receptor A1 (EC:2.7.10.1) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26)

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (5)

cpd:C00019 S-Adenosyl-L-methionine cpd:C00051 Glutathione cpd:C00155 L-Homocysteine hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase belongs in this pathway hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22) BLMH Bleomycin hydrolase possesses homocysteine thiolactonase activity Suszynsk et al, 2010 PON1 possesses homocysteine thiolactonase activity Bayrak et al, 2011 PON2 ""

hsa00380 Tryptophan metabolism - Homo sapiens (human) (5)

cpd:C00078 L-Tryptophan cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid cpd:C03722 Quinolinate hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05213 Endometrial cancer - Homo sapiens (human) (5)

hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7157 TP53; tumor protein p53

hsa00830 Retinol metabolism - Homo sapiens (human) (5)

cpd:C00376 Retinal cpd:C00473 Retinol cpd:C02075 Retinyl ester cpd:C02094 beta-Carotene hsa:9227 LRAT; lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (EC:2.3.1.135)

hsa05219 Bladder cancer - Homo sapiens (human) (5)

hsa:1612 DAPK1; death-associated protein kinase 1 (EC:2.7.11.1) hsa:3576 IL8; interleukin 8 hsa:4312 MMP1; matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04530 Tight junction - Homo sapiens (human) (5)

hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:4626 MYH8; myosin, heavy chain 8, skeletal muscle, perinatal hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) hsa:8735 MYH13; myosin, heavy chain 13, skeletal muscle hsa:9863 MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (5)

hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3586 IL10; interleukin 10 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:942 CD86; CD86 molecule

hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) (5)

hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:23607 CD2AP; CD2-associated protein hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:857 CAV1; caveolin 1, caveolae protein, 22kDa

hsa05310 Asthma - Homo sapiens (human) (5)

hsa:2206 MS4A2; membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) hsa:2207 FCER1G; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor

hsa04730 Long-term depression - Homo sapiens (human) (5)

cpd:C00025 L-Glutamate hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (5)

cpd:C00187 Cholesterol cpd:C00951 Estradiol-17beta hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

hsa04260 Cardiac muscle contraction - Homo sapiens (human) (5)

hsa:4512 COX1; cytochrome c oxidase subunit I hsa:4513 COX2; cytochrome c oxidase subunit II hsa:4514 COX3; cytochrome c oxidase III hsa:4519 CYTB; cytochrome b hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit

hsa05150 Staphylococcus aureus infection - Homo sapiens (human) (5)

hsa:3075 CFH; complement factor H hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3586 IL10; interleukin 10 hsa:720 C4A; complement component 4A (Rodgers blood group)

hsa04724 Glutamatergic synapse - Homo sapiens (human) (5)

cpd:C00025 L-Glutamate hsa:116443 GRIN3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00561 Glycerolipid metabolism - Homo sapiens (human) (5)

cpd:C00422 Triacylglycerol hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:3990 LIPC; lipase, hepatic (EC:3.1.1.3) hsa:4023 LPL; lipoprotein lipase (EC:3.1.1.34)

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (4)

hsa:2246 FGF1; fibroblast growth factor 1 (acidic) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:929 CD14; CD14 molecule

hsa00670 One carbon pool by folate - Homo sapiens (human) (4)

cpd:C00504 Folate hsa:25902 MTHFD1L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (EC:6.3.4.3) hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) hsa:4548 MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13)

hsa05210 Colorectal cancer - Homo sapiens (human) (4)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (4)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6256 RXRA; retinoid X receptor, alpha hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7157 TP53; tumor protein p53

hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) (4)

hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:27034 ACAD8; acyl-CoA dehydrogenase family, member 8 hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04512 ECM-receptor interaction - Homo sapiens (human) (4)

hsa:1301 COL11A1; collagen, type XI, alpha 1 hsa:3339 HSPG2; heparan sulfate proteoglycan 2 hsa:5649 RELN; reelin hsa:948 CD36; CD36 molecule (thrombospondin receptor)

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (4)

cpd:C00078 L-Tryptophan hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:875 CBS; cystathionine-beta-synthase (EC:4.2.1.22)

hsa05211 Renal cell carcinoma - Homo sapiens (human) (4)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05218 Melanoma - Homo sapiens (human) (4)

hsa:2246 FGF1; fibroblast growth factor 1 (acidic) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7157 TP53; tumor protein p53

hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human) (4)

cpd:C00253 Nicotinate cpd:C03722 Quinolinate hsa:349565 NMNAT3; nicotinamide nucleotide adenylyltransferase 3 (EC:2.7.7.1 2.7.7.18) hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1)

hsa05216 Thyroid cancer - Homo sapiens (human) (4)

hsa:4914 NTRK1; neurotrophic tyrosine kinase, receptor, type 1 (EC:2.7.10.1) hsa:5468 PPARG; peroxisome proliferator-activated receptor gamma hsa:6256 RXRA; retinoid X receptor, alpha hsa:7157 TP53; tumor protein p53

hsa04974 Protein digestion and absorption - Homo sapiens (human) (4)

cpd:C00025 L-Glutamate cpd:C00078 L-Tryptophan hsa:1301 COL11A1; collagen, type XI, alpha 1 hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)

hsa05214 Glioma - Homo sapiens (human) (4)

hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:7157 TP53; tumor protein p53

hsa04970 Salivary secretion - Homo sapiens (human) (4)

hsa:1471 CST3; cystatin C hsa:153 ADRB1; adrenergic, beta-1-, receptor hsa:154 ADRB2; adrenergic, beta-2-, receptor, surface hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)

hsa04114 Oocyte meiosis - Homo sapiens (human) (4)

hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:367 AR; androgen receptor hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (4)

hsa:3576 IL8; interleukin 8 hsa:5300 PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (EC:5.2.1.8) hsa:7124 TNF; tumor necrosis factor hsa:7186 TRAF2; TNF receptor-associated factor 2

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (4)

hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3586 IL10; interleukin 10 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00350 Tyrosine metabolism - Homo sapiens (human) (4)

hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:5409 PNMT; phenylethanolamine N-methyltransferase (EC:2.1.1.28)

hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) (4)

cpd:C00187 Cholesterol cpd:C13550 Cerebrosterol hsa:10858 CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1 (EC:1.14.13.98) hsa:9023 CH25H; cholesterol 25-hydroxylase (EC:1.14.99.38)

hsa05212 Pancreatic cancer - Homo sapiens (human) (4)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (4)

cpd:C00951 Estradiol-17beta hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:2099 ESR1; estrogen receptor 1 hsa:7421 VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor

hsa00860 Porphyrin and chlorophyll metabolism - Homo sapiens (human) (4)

cpd:C00025 L-Glutamate hsa:1352 COX10; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (EC:2.5.1.-) hsa:1355 COX15; COX15 homolog, cytochrome c oxidase assembly protein (yeast) hsa:3162 HMOX1; heme oxygenase (decycling) 1 (EC:1.14.99.3)

hsa04614 Renin-angiotensin system - Homo sapiens (human) (3)

hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:183 AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8) hsa:4311 MME; membrane metallo-endopeptidase (EC:3.4.24.11)

hsa04150 mTOR signaling pathway - Homo sapiens (human) (3)

hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7422 VEGFA; vascular endothelial growth factor A

hsa00750 Vitamin B6 metabolism - Homo sapiens (human) (3)

cpd:C00018 Pyridoxal phosphate cpd:C00250 Pyridoxal cpd:C00534 Pyridoxamine

hsa04912 GnRH signaling pathway - Homo sapiens (human) (3)

hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (3)

hsa:2876 GPX1; glutathione peroxidase 1 (EC:1.11.1.9) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa00340 Histidine metabolism - Homo sapiens (human) (3)

cpd:C00025 L-Glutamate hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05221 Acute myeloid leukemia - Homo sapiens (human) (3)

hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila) hsa:861 RUNX1; runt-related transcription factor 1

hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human) (3)

hsa:7099 TLR4; toll-like receptor 4 hsa:7534 YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide hsa:929 CD14; CD14 molecule

hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) (3)

hsa:2224 FDPS; farnesyl diphosphate synthase (EC:2.5.1.1 2.5.1.10) hsa:3156 HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (3)

cpd:C00187 Cholesterol hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:4036 LRP2; low density lipoprotein receptor-related protein 2

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) (3)

hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:4000 LMNA; lamin A/C hsa:783 CACNB2; calcium channel, voltage-dependent, beta 2 subunit

hsa00620 Pyruvate metabolism - Homo sapiens (human) (3)

hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa04012 ErbB signaling pathway - Homo sapiens (human) (3)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (3)

hsa:5933 RBL1; retinoblastoma-like 1 (p107) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor EPHA1 binds to SMURF2

hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) (3)

hsa:1738 DLD; dihydrolipoamide dehydrogenase (EC:1.8.1.4) hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61) hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (3)

hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:9846 GAB2; GRB2-associated binding protein 2

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (3)

hsa:10554 AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) (EC:2.3.1.51) hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human) (3)

cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid cpd:C06429 (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid hsa:9200 PTPLA; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (3)

hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (3)

hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146) hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (3)

hsa:3479 IGF1; insulin-like growth factor 1 (somatomedin C) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (3)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:6655 SOS2; son of sevenless homolog 2 (Drosophila)

hsa03040 Spliceosome - Homo sapiens (human) (3)

hsa:3304 HSPA1B; heat shock 70kDa protein 1B hsa:51503 CWC15; CWC15 spliceosome-associated protein homolog (S. cerevisiae) hsa:7919 DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (EC:3.6.4.13)

hsa05217 Basal cell carcinoma - Homo sapiens (human) (3)

cpd:C00187 Cholesterol hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:7157 TP53; tumor protein p53

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (3)

cpd:C00031 D-Glucose hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) hsa:7124 TNF; tumor necrosis factor

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (3)

hsa:157855 KCNU1; potassium channel, subfamily U, member 1 hsa:2767 GNA11; guanine nucleotide binding protein (G protein), alpha 11 (Gq class) hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) (2)

cpd:C06427 (9Z,12Z,15Z)-Octadecatrienoic acid hsa:50487 PLA2G3; phospholipase A2, group III (EC:3.1.1.4)

hsa04122 Sulfur relay system - Homo sapiens (human) (2)

cpd:C00019 S-Adenosyl-L-methionine cpd:C00378 Thiamine

hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate hsa:5105 PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)

hsa03030 DNA replication - Homo sapiens (human) (2)

hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) (2)

cpd:C00031 D-Glucose hsa:5295 PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) (2)

hsa:1445 CSK; c-src tyrosine kinase (EC:2.7.10.2) hsa:3576 IL8; interleukin 8

hsa00650 Butanoate metabolism - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate hsa:3158 HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (EC:2.3.3.10)

hsa00600 Sphingolipid metabolism - Homo sapiens (human) (2)

hsa:410 ARSA; arylsulfatase A (EC:3.1.6.8) hsa:8879 SGPL1; sphingosine-1-phosphate lyase 1 (EC:4.1.2.27)

hsa03013 RNA transport - Homo sapiens (human) (2)

hsa:7329 UBE2I; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (EC:6.3.2.19) hsa:7919 DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (EC:3.6.4.13)

hsa00230 Purine metabolism - Homo sapiens (human) (2)

hsa:4860 PNP; purine nucleoside phosphorylase (EC:2.4.2.1) hsa:5152 PDE9A; phosphodiesterase 9A (EC:3.1.4.35)

hsa04520 Adherens junction - Homo sapiens (human) (2)

hsa:29119 CTNNA3; catenin (cadherin-associated protein), alpha 3 hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B)

hsa04720 Long-term potentiation - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5)

hsa03430 Mismatch repair - Homo sapiens (human) (2)

hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa05340 Primary immunodeficiency - Homo sapiens (human) (2)

hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa03420 Nucleotide excision repair - Homo sapiens (human) (2)

hsa:5981 RFC1; replication factor C (activator 1) 1, 145kDa hsa:5983 RFC3; replication factor C (activator 1) 3, 38kDa

hsa00524 Butirosin and neomycin biosynthesis - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate cpd:C00031 D-Glucose

hsa04742 Taste transduction - Homo sapiens (human) (2)

cpd:C00025 L-Glutamate hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3

hsa04146 Peroxisome - Homo sapiens (human) (2)

hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)

hsa03015 mRNA surveillance pathway - Homo sapiens (human) (2)

hsa:5521 PPP2R2B; protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) hsa:7919 DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (EC:3.6.4.13)

hsa03410 Base excision repair - Homo sapiens (human) (2)

hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) hsa:4968 OGG1; 8-oxoguanine DNA glycosylase (EC:4.2.99.18) NCAPD2 (Binds to PARP1)

hsa00310 Lysine degradation - Homo sapiens (human) (2)

hsa:1743 DLST; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (EC:2.3.1.61) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human) (2)