The entire human genome is composed of viral DNA reflecting an evolutionary
descent as suggested by J.B.S.Haldane
and Felix
D'Herelle over a century ago, and the insertion of multiple
retroviral inserts over millions of years of co-existence, that are likely responsible
for evolutionary jumps. These sequences are contiguous gapped segments,
resulting in the translation, to protein, of millions of contiguous amino acid
stretches 5-12 amino acids long (Vatches). These are homologous to proteins
expressed by today's viruses and other pathogens. Viral infection will therefore
interfere with host protein networks, and antibodies to the virus may also target
the human homologous proteins leading to immune-related protein knockdown, and
in some cases autoimmune destruction of the cells containing the human counterpart.
This scenario is relevant to most, if not all, human diseases.
The results below are the raw BLAST data from various queries between viral
or bacterial genes, proteins , genomes or proteomes with their human equivalents.
So far only a few viruses have been examined. The prediction of millions of
viral inserts within the human genome is based on almost 3000 viral genomes
so
far sequenced in the NCBI
database and also on over 22,000 viral strains These represent but a small
fraction of the strains involved. Each viral replication within each infected
individual
worldwide will also generate novel viral genomic DNA. The files appended here
represent more than 2 million alignments and many more short homologous segments
within these alignments.
Note: The Blasts returned were filtered as described in the table. Note that
the BLAST results returned are subject to a cut-off value of 20,000 alignments
which was generally exceeded. Usually a different set of results, as equally
impressive and numerous can be returned using a different filter. For example
compare the divers hits to Herpes simplex.filtered with various queries.
Vatches can easily be found by searching the phrase "identities = 7/7"
or 6/6 , or 8/10 etc within the BLAST files: Those reported below are the isolated
vatches and do not include those within larger sequences which have to be eyeballed
individually. Genes can be found by searching for the phrase "Gene id"
Scrutiny of these files suggests several basic rules for pathogenetic diseases
as discussed, and exemplified at greater length in these
papers.
TG = Translated genome HP = Human proteome;. BP = Bacterial protein; VP = Viral
protein; FP = Fungal protein; YP= Yeast protein
For example, the repetitive patterns on the BLAST below (HSV-1 in human) represent
different human proteins from the same family, on different chromosomes
Alzheimer's disease |
Autoantibodies in Alzheimer's disease
Viral homologues in red in progress
Beta Amyloid |
Query |
Subject |
Filter |
Results: The size of the
tags in the clouds reflect the number of pathogen homologues per human
protein from the BLAST files accessible from the right hand column: Note
that the profile is distinct for each virus.
In some cases, a gene labelled as unknown in the BLAST files
turned out to be APP or CR1,or NRG1 etc, and some of these errors have
been rectified for the most important genes |
BLAST Files
Number of significant alignments |
|
|
Herpes simplex HSV-1 NC_001806.1 |
Found
in the Alzheimer's disease brain. HSV-1 infection causes beta-amyloid deposition,
tau phosphorylation, entorhinal and hippocampal neuronal loss, cerebral
shrinkage and memory deficits |
Autoantigens in Alzheimer's disease
from
and Here
Tag sizes reflect the number of pathogen proteins homologous to the human
protein |
|
Beta-amyloid Helicobacter
pylori Borrelia
Cryptococcus
neoformans Herpesvirus
5 Porphyromonas
gingivalis Rhinovirus
Human
immunodeficiency virus herpesvirus
6 Herpesvirus
1 |
BLAST |
BPTF (Falz) Porphyromonas
gingivalis Herpesvirus
6 Herpesvirus
1 Human
immunodeficiency virus Borrelia
Cryptococcus
neoformans Helicobacter
pylori Herpesvirus
5 |
BLAST |
AZGP1Herpesvirus
1 Herpesvirus
6 Cryptococcus
neoformans Borrelia
Porphyromonas
gingivalis Herpesvirus
5 Helicobacter
pylori Human
immunodeficiency virus |
BLAST |
GFAP Herpesvirus
1 Herpesvirus
6 Helicobacter
pylori Cryptococcus
neoformans Herpesvirus
5 Human
immunodeficiency virus Borrelia
Porphyromonas
gingivalis |
BLAST |
KRT10 Herpesvirus
5 Human
immunodeficiency virus Porphyromonas
gingivalis Borrelia
Cryptococcus
neoformans Herpesvirus
1 Herpesvirus
6 Helicobacter
pylori |
BLAST |
LAMB2 Laminin |
BLAST |
MAPT Human
immunodeficiency virus Herpesvirus
1 Cryptococcus
neoformans Helicobacter
pylori Porphyromonas
gingivalis Borrelia
Herpesvirus
6 Herpesvirus
5 |
BLAST |
MBPHerpesvirus
6 Helicobacter
pylori Human
immunodeficiency virus Herpesvirus
1 Cryptococcus
neoformans Porphyromonas
gingivalis Herpesvirus
5 Borrelia
|
BLAST |
NEFH Human
immunodeficiency virus Porphyromonas
gingivalis Helicobacter
pylori Cryptococcus
neoformans Herpesvirus
5 Borrelia
Herpesvirus
1 Herpesvirus
6 |
BLAST |
NGFHerpesvirus
1 Human
immunodeficiency virus Porphyromonas
gingivalis Herpesvirus
6 Helicobacter
pylori Herpesvirus
5 Borrelia
Cryptococcus
neoformans |
BLAST |
RABEP1 |
BLAST |
SLC4A3Human
immunodeficiency virus Herpesvirus
6 Helicobacter
pylori Herpesvirus
1 Herpesvirus
5 Borrelia
Porphyromonas
gingivalis Cryptococcus
neoformans |
BLAST |
SPTAN1 Cryptococcus
neoformans Herpesvirus
1 Human
immunodeficiency virus Borrelia
Herpesvirus
6 Herpesvirus
5 Porphyromonas
gingivalis Helicobacter
pylori |
BLAST |
S100B Cryptococcus
neoformans Herpesvirus
6 Herpesvirus
1 Porphyromonas
gingivalis Helicobacter
pylori Borrelia
Herpesvirus
5 Human
immunodeficiency virus |
BLAST |
Thyroglobulin Helicobacter
pylori Human
immunodeficiency virus Porphyromonas
gingivalis Borrelia
Herpesvirus
6 Cryptococcus
neoformans Herpesvirus
1 Herpesvirus
5 |
BLAST |
TG |
HP |
None |
DNA polymerase Uracil glycosylase Ribonucleotise reductase GSK3B |
221 |
|
|
Alzheimer
All genes on the right have been implicated in genetic association studies |
|
|
|
|
19520 |
|
|
Adhesion |
COL12A1: DSCAML1 : PCDH15 : PLXNB1 |
50648 |
|
|
Cholesterol |
CEL : CYP46A1 : LRP10 : NPC1 : OSBP1 |
63909 |
|
|
Growth Factor |
BDNF FGF2 NRG2 OGFR VEGFA |
31688 |
|
|
Homocysteine |
AHCYL2 FTSJD2 MLL4 SETD1B TARBP1 |
99564 |
|
|
Immune |
FASLG TNF MMP16 NFATC2 TP53 |
32069 |
|
|
Lipoprotein |
ABCA1 LDLR LRP1 LRP2 LRP3 LRP4 LRP5 LRP6 LRP8 LRP10 SREBF1 SORL1 |
42300 |
|
|
Mitochondria |
CACNA2D2 DLST MTCH1 PLSCR3 SIRT3 TK2 TOMM40 TSPO |
50709 |
|
|
|
Monoamine |
AOC2 MAOA MAOB SLC22A3 VMAT2 |
46016 |
|
|
|
|
CR1 |
CR1 fractalkine |
171264 |
Cytomegalovirus NC_006273.2 |
Overall
Viral burden is associated with cognitive decline |
TG |
HP |
Alzheimer |
|
20270 |
|
|
CR1 lipoprotein |
yyy |
HHV-6 |
Found
in the Alzheimer's disease brain |
|
|
Alzheimer |
|
22405 |
|
|
|
|
yyy |
Rhinovirus 14 NC_001490.1 |
None found |
TG |
HP |
Alzheimer
All genes on the right have been implicated in genetic association studies |
ND3
CACNB2
KIF20B
APBA1
DLST
SNCA
CH25H
ECE1
BPTF(fALZ)
APP
TF
CDK5R1
PSEN2
APBB2
SORCS3
BIN1
TAPBPL
CLU
GOLM1
FKBP1A
FAM3A
YME1L1
NOTCH4
TET1
BLMH
DPYSL2
GAB2
LRP8
SMNDC1
LRP1
SHISA4
APLP1
SERPINA3
ND2
TFCP2
UBQLN1
MAZ
LRRTM3
RALGPS2
IL1A
NCSTN
PEN2
PLAU
CYTB
PTPLA
ITM2B
DLD
BDNF
GDI2
APOE4
ITMA2
ZNF225
GAPDH
SGPL1
PZP
SERPINI1
OLR1
CALHM1
ND4
ATP6
HMGCR
PSEN1
IFIT5
PICALM
MAPK8IP1
ND4L
ATP8
APBB1
MICB
SORCS1
PHYH
COL25A1
CHAT
NCAPD2
ND6
SMPD1
IDE
APBB3
FAM113B
OAT
NQO1
S100B
ND5
CTNNA3
HMOX1
RELN
BACE2
GSK3B
COX2
SLC6A4
CLSTN1
PCDH11X
MAPK10
PRNP
MAPT
CELF5
COX3
NMNAT3
BACE1
PDLIM1
ALDH18A1
CTSD
ND1
APOE
SORL1
UCHL1
ZNF224
DHCR24
|
7862 |
|
|
CR1 lipoprotein |
|
yyy |
HIV-1 NC_001802.1 |
Causes
dementia with Alzheimer's disease pathology |
TG |
HP |
Alzheimer |
CLU
SLC17A5
S100B
FKBP1A
SLC6A4
CTSD
HMGCR
YME1L1
BACE2
CHRM1
DKK1
CX3CL1
KIN
GAB2
CHAT
TAPBPL
ND2
TDGF1
PRNP
TFCP2
CH25H
PHYH
NOTCH4
UCHL1
CST3
APBA1
APBB2
APPBA2
DLST
TET1
CTNNA3
COL25A1
CHRNA4
C4B
PZP
COX3
SORCS1
ENTPD2
SMPD1
BTPF(Falz)
SERPINA3
COPS8
MAPK8IP1
BDNF
RALGPS2
NMNAT3
OAT
CDK5R2
SNCA
PICALM
APOE
APP
SERPINI1
SORCS3
ECE1
SHISA4
IFIT5
SORL1
GAPDH
ITM2B
ATP8
NQO1
A2M
NCSTN
PSEN1
TOMM40
CALHM3
PSEN2
C3
KIF20B
GDI2
PCDH11X
APBB3
CALHM1
IDE
PEN2
APBB1
NADH4L
COX2
RELN
GOLM1
HMOX1
FAM3A
GSK3B
ND1
APOE4
UBQLN1
DHCR24
ND6
TF
ND4
ZNF225
LRP8
ITMA2
MAPK10
MAPT
PTPLA
DNMBP
DPYSL2
CELF5
CR1
NCAPD2
BACE1
LRRTM3
ALPL1
ND3
CACMB2
PDLIM1
CALHM2
PLAU
MICB
MAP2
CR1L
OLR1
BLMH
DLD
LRP1
BIN1
ZNF224
BTVD16
|
9921 |
|
|
|
|
|
CR1 lipoprotein |
|
yyy |
Chlamydophila pneumoniae NC_005043.1 |
Found
in in Alzheimer's disease brain and produces beta-amyloid deposition in
mice |
TG |
HP |
Alzheimer |
|
17132 |
|
|
CR1 lipoprotein |
Redo |
Borrelia Burgdorferii NC_011728.1 |
Found
in amyloid plaques in Alzheimer's disease and produces beta-amyloid deposition
in mice |
TG |
HP |
Alzheimer |
|
14822 |
|
|
CR1 lipoprotein |
225900 |
Helicobacter pylori NC_014256.1 |
Eradication
ameliorates cognitive function |
TG |
|
Alzheimer |
|
18082 |
|
|
CR1 lipoprotein |
yyy |
Porphyromonas gingivalis ATCC 33277 NC_010729.1 |
Tooth
loss and poor dental health associated with Alzheimer's disease |
TG |
|
Alzheimer |
|
17561 |
|
|
CR1 lipoprotein |
|
19479 |
C.Neoformans |
C.Neoformans
eradication cured Alzheimer's disease in 2 case reports |
|
|
|
Chromosomes
are duplicated in C.Neoformans accounting for the similarity below |
|
|
|
|
|
TG |
|
Alzheimer |
CHAT
PLAU
MAPK10
RALGPS2
NCAPD2
LRP8
DNMBP
CDK5R2
S100B
NMNAT3
TFCP2
APBB3
APPBA2
SLC6A4
NOTCH4
GAB2
CALHM3
APOE
SORCS3
BDNF
PZP
COL25A1
MAP2
APBB1
SORL1
CR1L
FAM3A
APBA1
SNCA
ITMA2
COX3
PRNP
HMOX1
ITM2B
SERPINA3
IFIT5
CTNNA3
CST3
BIN1
ATP8
MICB
ZNF225
TF
TDGF1
UCHL1
NCSTN
ND1
HMGCR
ND3
KIF20B
DKK1
COX2
ECE1
ND6
ND5
C3
CLU
PTPLA
CALHM1
NADH4L
GSK3B
SHISA4
CH25H
KIN
CTSD
CR1
OLR1
SERPINI1
A2M
GAPDH
ZNF224
APOE4
DHCR24
PDLIM1
CALHM2
RELN
DLD
BTBD16
TAPBPL
CX3CL1
LRP1
APP
PHYH
ND4
MAPK8IP1
GDI2
DPYSL2
IL1A
LRRTM3
FKBP1A
UBQLN1
DOCK3
NQO1
PEN2
PSEN1
SLC17A5
CACNB2
SORCS1
APLP1
SMPD1
APBB2
TOMM40
TET1
COPS8
BLMH
MAPT
PCDH11X
IDE
BACE2
CELF5
GOLM1
PICALM
BACE1
ENTPD2
|
16474 |
CR1 lipoprotein |
yyy |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo.II. CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
16396 |
CR1 lipoprotein |
329613 |
|
|
TG |
|
Alzheimer |
104
Alzheimer's disease susceptibility genes hits to C.Neo.III CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA
TFCP2 ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B
SORCS1 SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2
CALHM3 CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A
FKBP1A GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3
MAPK10 MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
16932 |
CR1 lipoprotein |
374183 |
|
|
TG |
|
Alzheimer |
104
Alzheimer's disease susceptibility genes hits to C.Neo IV CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
14771 |
CR1 lipoprotein |
323537 |
|
|
TG |
|
Alzheimer |
105
Alzheimer's disease susceptibility genes hits to C.Neo V CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BLMH BTBD16 CALHM1 CALHM2
CALHM3 CBARA1 CDK5R2 CELF5 CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A
FKBP1A GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3
MAPK10 MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 C2H25H MARK1 |
21216 |
CR1 lipoprotein |
313741 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo VI CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
20842 |
CR1 lipoprotein |
305638 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo VII CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
15394 |
CR1 lipoprotein |
293601 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo VIII CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA
TFCP2 ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B
SORCS1 SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2
CALHM3 CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A
FKBP1A GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3
MAPK10 MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
15988 |
CR1 lipoprotein |
292701 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo IX CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
21813 |
CR1 lipoprotein |
289976 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo X
CR1 APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2
APBB3 CLU COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2
CHAT COX3 NADH4L OLR1 SNCA TFCP2 ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B
IDE LRP1 PHYH PLAU RELN S100B SORCS1 SORL1 TF UBQLN1 C4B CST3 A2M APBA1
APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3 CDK5R2 CELF5 CH25H CTNNA3 CTSD
DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A GAPDH GOLM1 HMGCR HMOX1 IFIT5
IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10 MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3
NOTCH4 PDLIM1 PEN2 PICALM PRNP PTPLA PZP RALGPS2 SERPINA3
SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3 TAPBPL TET1 TOMM40 UCHL1 ZNF224
ZNF225 BLMH |
20297 |
CR1 lipoprotein |
275497 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo XI CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
15278 |
CR1 lipoprotein |
262729 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo XII CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
12842 |
CR1 lipoprotein |
273108 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo XIII CR1
APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2 APBB3 CLU
COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2 CHAT COX3 NADH4L OLR1 SNCA TFCP2
ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B IDE LRP1 PHYH PLAU RELN S100B SORCS1
SORL1 TF UBQLN1 C4B CST3 A2M APBA1 APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3
CDK5R2 CELF5 CH25H CTNNA3 CTSD DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A
GAPDH GOLM1 HMGCR HMOX1 IFIT5 IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10
MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3 NOTCH4 PDLIM1 PEN2 PICALM
PRNP PTPLA PZP RALGPS2 SERPINA3 SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3
TAPBPL TET1 TOMM40 UCHL1 ZNF224 ZNF225 BLMH |
13997 |
CR1 lipoprotein |
249037 |
|
|
TG |
|
Alzheimer |
103
Alzheimer's disease susceptibility genes hits to C.Neo XIV
CR1 APP APPBA2 BIN1 MAPT PSEN2 BACE1 PSEN1 BDNF APBB2
APBB3 CLU COL25A1 COX2 ECE1 LRP8 ND3 APBB1 NQO1 BACE2
CHAT COX3 NADH4L OLR1 SNCA TFCP2 ATP8 CACNB2 COPS8 DLD GAB2 GDI2 GSK3B
IDE LRP1 PHYH PLAU RELN S100B SORCS1 SORL1 TF UBQLN1 C4B CST3 A2M APBA1
APLP1 APOE BTBD16 CALHM1 CALHM2 CALHM3 CDK5R2 CELF5 CH25H CTNNA3 CTSD
DHCR24 DKK1 DLST DNMBP DPYSL2 FAM3A FKBP1A GAPDH GOLM1 HMGCR HMOX1 IFIT5
IL1A ITM2B ITMA2 KIF20B KIN LRRTM3 MAPK10 MAPK8IP1 MICB NCAPD2 NCSTN NMNAT3
NOTCH4 PDLIM1 PEN2 PICALM PRNP PTPLA PZP RALGPS2 SERPINA3
SERPINI1 SHISA4 SLC17A5 SLC6A4 SMPD1 SORCS3 TAPBPL TET1 TOMM40 UCHL1 ZNF224
ZNF225 BLMH |
14793 |
CR1 lipoprotein |
244187 |
APOE 4 |
|
|
VP |
None |
|
127 |
APOE 4 |
|
Vir P |
None |
102
No HIV
107
with HIV |
APOE 4 |
|
Bact P |
|
|
|
APOE 4 |
|
Yeast P |
|
|
173 |
|
|
Fungi P |
|
|
131 BLAST |
APOE 4 |
|
Rhinovirus |
|
|
586 |
APOE 4 |
|
HIV1 |
|
|
884 |
APOE 4 |
|
Allergen |
|
Allergen |
508 |
APOE 4 |
|
None |
|
|
Beta amyloid |
|
VGGVV |
VP |
|
69
Phages and viruses with 100% identity |
APP |
|
Beta amyloid 1-42 |
VP |
|
385
viral and phage hits |
APP mutants |
The localisation of the APP 717 and swedish mutations, in
red, and of the beta- and gamma-secretase (ß and
γ) cleavage sites . The beta-amyloid
sequence is in blue. The peptides used for homology searches are underlined
- ...LTNIKTEEISEVKMßDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVγIATVIVITLVMγLKKK
- Swedish .....EISEVNL
- 717 mutants.........................................................................................................................V>F:
V>G: V>I: V>L AD
and FTD mutation database
|
|
APP |
|
V717 |
VP |
|
|
122 |
|
V717 |
BP |
|
|
111 |
|
F717 |
VP |
|
|
BLAST |
|
F717 |
BP |
|
|
111 |
|
G17 |
BP |
|
|
108 |
|
G17 |
VP |
|
|
BLAST132 |
|
I717 |
BP |
|
|
102 |
|
I717 |
VP |
Phages of commensal bacteria or common viruses in
red. |
|
BLAST |
|
L717 |
BP |
|
|
|
|
L717 |
VP |
|
|
|
|
Swedish normal |
VP |
|
|
112 |
|
BP |
|
|
100 |
|
FP YP |
|
|
107 |
|
Swedish
Mutant |
VP |
Commensal bacteria phages and common viruses in
red |
|
ddd |
|
BP |
Commensal bacteria in red
* links to PUBMED |
|
100 |
|
FP YP |
|
|
ddd |
Abeta Catalytic antibody sites Taguchi
et al 2008 |
Catalytic autoantibodies are less likely to mount
a full-blown autoimmune response and will destroy beta-amyloid |
HHQKL |
VP |
The huge number of viruses homologous to such short stretches illustrates
the magnitude of viral insertion over millions of years |
Kaposi's sarcoma virus (HSV-8) Papillomavirus and other cancer
viruses (in red)
Cancer
is inversely associated with Alzheimer's disease risk
|
sss |
KGAI |
|
|
Influenza (Flu
vaccines reduce AD risk) Bovine
foamy virus Bat
coronavirus Bovine
viral diarrhea virus Leucania
separata nuclear polyhedrosis virus Mink
coronavirus Taura
syndrome virus Bacillus
phage Pseudomonas
phage Listeria
phage garlic
latent virus Clostridium
phage Invertebrate
iridescent virus Marseillevirus
Lymantria
xylina MNPV Swinepox
virus Synechococcus
phage Paramecium
bursaria Chlorella virus Beluga
Whale coronavirus Emiliania
huxleyi virus Dengue
virus Grass
carp hemorrhagic virus Infectious
bronchitis virus Potato
virus Y Human
coxsackievirus Influenza
B virus Klebsiella
phage Apple
stem pitting virus Acanthocystis
turfacea Chlorella virus Sugarcane
streak mosaic virus Murid
herpesvirus 1 Gallid
herpesvirus 2 Phlebiopsis
gigantea mycovirus Streptococcus
pyogenes phage Ryegrass
mosaic virus Staphylococcus
phage Powassan
virus Nariva
virus Felid
herpesvirus 1 Sorghum
chlorotic spot virus Sunflower
chlorotic mottle virus Cymbidium
mosaic virus Yaba-like
disease virus Deftia
phage Brochothrix
phage Ljungan
virus Torque
teno virus Deerpox
virus podovirus
Acanthamoeba
polyphaga mimivirus Choristoneura
occidentalis granulovirus Haemophilus
phage Lumpy
skin disease virus Lactococcus
lactis phage Canarypox
virus Burkholderia
ambifaria phage Sweet
potato feathery mottle virus Burkholderia
phage Mycobacterium
phage Spring
viraemia of carp virus Grapevine
leafroll-associated virus Human
immunodeficiency virus 1 Human
herpesvirus 8 Mammalian
orthoreovirus Chrysanthemum
stem necrosis virus Enterobacteria
phage Hendra
virus Tellina
virus Adoxophyes
orana granulovirus Duck
hepatitis A virus Rice
tungro spherical virus Streptococcus
phage Cyanophage
Acinetobacter
phage Roseophage
harvest
mouse papillomavirus Influenza
A virus Arabis
mosaic virus Citrus
psorosis virus Squash
mosaic virus Halomonas
phage Allpahuayo
virus Bacillus
phage Peach
chlorotic mottle virus Avian
paramyxovirus Ostreid
herpesvirus St.
Louis encephalitis virus SARS
coronavirus Yersinia
phage Carnation
Italian ringspot virus Ostreococcus
tauri virus Infectious
salmon anemia virus Enterococcus
phage Muromegalovirus
Pyrococcus
abyssi virus Chilli
veinal mottle virus Enterococcus
phage Erwinia
phage Tobacco
mild green mosaic virus Iodobacteriophage
Citrus
idaeovirus Prochlorococcus
phage Crimean-Congo
hemorrhagic fever virus Debaryomyces
hansenii virus Pepper
veinal mottle virus Vibrio
phage Diatraea
saccharalis densovirus Human
rhinovirus Bordetella
phage Watermelon
mosaic virus Goatpox
virus Pellor |
xxx |
Multiple Sclerosis |
|
|
|
|
|
|
|
|
Epstein-Barr (no filter)Many
studies have implicated the Epstein-Barr virus in Multiple sclerosis
EIF2B
causes vanishing white matter disease
|
ATPBD4
SF1
NRARP
SOCS7
PKD2
CDAN1
RASA4
IER3
ZC3H18
CEP135
CC2D1B
SAV1
FAM8A1
KANK2
UNG
COL18A1
GPR128
FAM120C
QSOX2
PLEKHG4
PLEKHG5
EMID1
ANXA6
AKAP13
SPIB
LAG3
DKK2
fertilin
beta BRAP
PLCE1
MUC5B
TPRN
PLEKHA7
VEGFA
STXBP5L
alpha-1,4-galactosyltransferase
EXO3CL2
HK3
peripheral
myelin protein 22 MCM3AP
MTSS1
ABCA7
RAB3IP
HLA-B
associated transcript 3 PPP1R14B
PLXNB3
NUDT14
bullous
pemphigoid antigen KAZ
TRIP6
MPEPL1
ZAP70
IRAK1
ATE1
MUC16
CIT
DRPLA
RAI1
GPR124
HTR3C
calcium
channel, voltage-dependent, L type, alpha 1D RRM2B
SRRM3
RBM25
CCDC90A
DOK7
DNAJC14
TSPAN3
ELN
REEP1
BCL2L12
TTC19
INS-IGF2
SYNGR2
MSLN
BRD4
MLLT1
MA
HNRNPUL1
eukaryotic
translation initiation factor 4 gamma 3 STAB2
SLC6A5
MTCH1
WIZ
IQCK
MEOX1
IMMT
CRIPAK
MED15
MAVS
RGL3
GPRIN1
MHC
class I antigen immunoglobulin
heavy chain variable region ZCCHC24
TBC1D9
PCD10
RPGRIP1L
EGLN2
CEACAM16
WNK2
PLEKHH1
RRM2
DDX31
RRM1
ADNP2
WNK1
TOM1
MUC2
MUC12
MON1B
ZNF280B
ZMYM3
PARVA
CUX1
SPRR2D
FBLN2
SMPDL3A
ACACB
TMEM132A
GRM7
RASSF7
MAN1A1
XIRP1
ODF3B
RGMB
ABCB11
TWF1
HMX1
TSC2
C2CD3
CDKL5
PRDM16
T
calcium channel alpha 1G subunit LCN8
DYNC1LI2
LOC100129852
ZDHHC14
GAA
PRNP
COL4A3
TSL
CHRNA4
IMPG1
PHYH
RAB44
COL1A1
ryanodine
receptor 3 ZNF318
DPH2
ZNF579
NCOA6
PPM1H
PKN1
KDM4B
CEBPA
ROBO4
PTCHD2
FBXO17
IL1F10
SDK2
RCN2
OAZ1
ITGB2
ALDH1L1
MAPRE3
AATK
ANKRD11
neuregulin
1 SCRIB
CD80
PLCH2
MTFMT
Epstein-Barr
virus induced gene 3 OPN4
CCBE1
SRRM4
SRD5A1
ANKRD33B
CAMK2B WDR67
ADRB1
LIPT2
CCDC12
PRICKLE1
MTRF1L
RNASEK
SGK2
POLA1
MARVELD3
TNFRSF25
SLC45A3
CCDC102A
ALDH3A1
ST8SIA3
POLD1
HSCB
PNLDC1
TRIM26
CASKIN1
SLC39A7
MUC5AC
PRRT4
LINGO1
UBE4B
VEGFR1
REV3L
TTYH1
UPS42
NLGN2
RAPGEF1
PIDXL
RGH14
CTAGE5
ADAM33
SYNJ1
EFR3B
RAMP3
SLC4A11
MTX1
GREB1L
immunoglobulin
kappa light chain variable region ERN2
IL10
UBR5
MARCH9
PLXNA4
FOXC2
IDUA
PSMB11
TCP10L2
NXPH4
PRX
BSCL2
ZNF173
ATXN2
PFAS
TGFA
PIF1
schwannomin
interacting protein 1 C2CD4D
TUBB8
FOXK1
SSH1
sodium
channel nonvoltage-gated 1 delta
AFAM2 TCEB3B
ZNF716
SLC25A48
PRKCA
TCP10
cytochrome
oxidase subunit II SHANK1
TPBG
AHCYL2
LTC4S
PLEKHA4
|
284 |
|
|
28280 |
|
IFNAR1 CBLB PARD3B NFASC POU2AF1 MBP CD97 CLDN11 MATN3 MMP28 RNF19A RAD54B C6orf27 LAMB2 HTATIP2 TRIM15 TNFSF12 XRCC1 T
cell receptor alpha RPL19 CD2 OPTN eIF2B OGG1 PDE4B HS3ST2 IL22RA1 LEKR1 DARS2 DCLRE1C KCNB2 TMEM39A SMUG1 CD247 BRCA2 IRF5 BUD13 PDZRN4 ECE2 CACNG4 SLC44A4 NUDT4 KLC1 IL16 CEP170 CENPC1 PREP CD2AP NHEJ1 HLA-DRB5 ERCC1 GFI1 CYFIP2 EVI5 EN1 PKN1 PLCE1 ZP4 HLA-DRA CIITA MMP25 MMP9 RAD51 KCNJ7 C4A GABBR1 LIG3 MX1L XRCC2 TKT IL7R CNP FMN2 GRN PAM LMNB1 HAVCR2 ZIC1 WDR64 RPA1 PCSK5 immunoglobulin
gamma heavy chain SHROOM3 ADNP RAD23A OLIG1 HDAC11 ALS2 NBN ICAM3 RAD54L FH CBLN2 TLR3 EPC1 WDR7 MNAT1 NRLP11 SH2B3 CD58 FEN1 GBP1 SNPH KIF1A MUTYH KLRB1 RFC1 RAD51L3 XRCC3 CNTF SPG11 SLC25A36 POLG CYP27B1 MPG VPS54 VAV2 OAS3 CCNH NTHL1 PTPRZ1 CYP24A1 CLEC16A T-cell
receptor beta APEX2 RAD51C ADAMTSL1 HELZ NEIL2 BDNF MYO9B METTL1 MUS81 SPARCL1 CHRND FLNA C4orf33 BICD1 KIF21B CYP4V2 IRF9 KANK1 LILRA3 BANK1 PGGT1B HSPB2 MPHOSPH9 T
cell receptor delta POLE WT1 LINGO1 ENTPD1 RGNEF POLD1 OLIG3 ADAMTS14 CASP8 JARID2 SH2D2A XAB2 EME1 OPN3 NDUFS5 CTGF POL3RC CNTN2 SCHIP1 USP31 SLC25A27 DCP1A H6PD GDF5 GPC5 HCRT IFNGR2 XRCC4 PARP2 PRKDC PSMD2 ERCC8 NCKAP5 PDMB9 RAD52 TSC2 C1orf125 BSV CD6 FURIN ADAD1 ALK CD200R1 ERCC3 SMAD7 ERVWE1 SYN3 MMS19 IFIH1 ASAP1 MERTK RGMA |
|
Autoantigens |
|
|
VP |
none |
|
|
Crystallin CRYAB
BLAST Autoantibodies
identified by microarray |
|
|
|
|
|
xxx |
CNP NP_149124:2',3'-cyclic-nucleotide 3'-phosphodiesterase
BLAST |
|
|
Myelin oligodendrocyte protein No filter
none Red viruses in all cases have been implicated
as risk factors or disease modifying agents in MS or in demyelination;
These are linked to Pubmed |
Nemesia
ring necrosis virus Feline
infectious peritonitis virus (cat ownership linked with MS) Seoul
virus Lumpy
skin disease virus Spodoptera
litura NPV Nyamanini
virus Grapevine
chrome mosaic virus Human
herpesvirus 4 Hepatitis
delta Beet
western yellows Bacillus
phage Turnip
mosaic virus Streptococcus
pyogenes phage
Heliothis armigera cypovirus Emiliania
huxleyi virus Bovine
enteric calicivirus Clostridium
phage Cypovirus
Acanthamoeba
polyphaga mimivirus Citrus
tristeza virus Border
disease virus Epstein-BarrMurine
hepatitis virus Marseillevirus
Merino
Walk virus shrimp
white spot syndrome virus coxsackievirus
Human
immunodeficiency virus Yokose
virus Human
astrovirus Avian
orthoreovirus Mycobacterium
phage influenza
a Mokola
virus poliovirus
Phocoena
spinipinnis papillomavirus Bombyx
mandarina nucleopolyhedrovirus Watermelon
mosaic virus Gallid
herpesvirus 2 Temperate
phage Mumps
virus Louping
ill virus |
101 |
Myelin associated glycoprotein
No filter |
MAGVPnoneEnterobacteria
phage Mamestra
configurata Corynebacterium
phage Lily
virus X Psittacid
herpesvirus Adult
diarrheal rotavirus Yersinia
phage Mycobacterium
phage Vibrio
phage Influenza
A virus Papillomavirus
Euproctis
pseudoconspersa nucleopolyhedrovirus Pseudomonas
phage Streptococcus
phage Actinomyces
phage Pelargonium
zonate spot virus Lactococcus
phage Molluscum
contagiosum virus Marseillevirus
Bacillus
phage Burkholderia
phage Human
herpesvirus 5 Allium
virus Musca
domestica salivary gland hypertrophy virus Epstein-Barr
Colorado
tick fever virus Staphylococcus
phage Ralstonia
phage |
111 |
Myelin Basic protein |
Theiler's
encephalomyelitis virus Epstein-Barr
Bean
yellow disorder virus Rotavirus
A Influenza
A Citrus
tristeza virus Measles
virus Yersinia
phage Lactococcus
phage Rabbit
hemorrhagic disease virus Enterobacteria
phage Broome
virus Campylobacter
phage Human
herpesvirus 3 Human
herpesvirus 2 Listeria
phage Human
adenovirus 4 Human
herpesvirus 7 Hepatitis
delta Polyoma
virus Human
T-lymphotropic virus Newcastle
disease virus Sapovirus
Pepino
mosaic virus Hepatitis
C Torque
teno virus sea
trout rhabdovirus Banna
virus Rubella
virus Marseillevirus
Hepatitis
B Rice
stripe virus Human
parvovirus Norovirus
Bacillus
phage Felid
herpesvirus 1 (cat ownership) |
123 |
EIF2B5 Not demonstrated as an autoantigen, but homologous
with Epstein-Barr |
Enterococcus
phage Ateline
herpesvirus 3 Mouse
parvovirus Canine
papillomavirus (Dog ownership) Human
herpesvirus 8 Yersinia
phage Human
herpesvirus 5 Latino
virus Bacillus
thuringiensis phage Murid
herpesvirus 2 Oryza
rufipogon endornavirus Canarypox
virus Bean
common mosaic necrosis virus Haemophilus
phage Actinoplanes
phage Equid
herpesvirus 4 Mycobacterium
phage Human
adenovirus Streptococcus
phage Human
herpesvirus 1 Human
enterovirus Corynebacterium
phage Ralstonia
phage Alfalfa
mosaic virus Burkholderia
phage Rubella
virus Bacillus
phage Helicoverpa
armigera NPV Hepatitis
C Enterobacteria
phage Klebsiella
phage Equine
rhinitis B virus Escherichia
phage Acidianus
two-tailed virus Tupaiid
herpesvirus Cyprinid
herpesvirus 3 Norwalk
virus Hyperthermophilic
Archaeal Virus Lymphocystis
disease virus Human
metapneumovirus Spinach
latent virus Camelpox
virus Saimiriine
herpesvirus 2 Listeria
phage Trichoplusia
ni SNPV Ostreococcus
virus Poliovirus
SARS
coronavirus Soybean
chlorotic mottle virus Staphylococcus
phage Choristoneura
occidentalis granulovirus Streptomyces
phage Porcine
adenovirus Shigella
phage Ostreococcus
tauri virus 1 Marseillevirus
Vibrio
phage Japanese
encephalitis virus] Agrotis
ipsilon multiple nucleopolyhedrovirus Ictalurid
herpesvirus 1 Mumps
virus Cowpox
virus [Botrytis
cinerea debilitation-related virus Variola
virus Lactobacillus
phage Suid
herpesvirus 1 Human
herpesvirus 4 Shrimp
white spot syndrome virus Plutella
xylostella granulovirus Lactococcus
phage Felid
herpesvirus 1 Clanis
bilineata nucleopolyhedrosis virus Acanthamoeba
polyphaga mimivirus West
Nile virus Glossina
pallidipes salivary gland hypertrophy virus Human
herpesvirus 6 Measles
virus Rachiplusia
ou MNPV Ectocarpus
siliculosus virus 1 Musca
domestica salivary gland hypertrophy virus Clostridium
phage Human
herpesvirus 3 Human
papillomavirus Human
herpesvirus 7 St.
Louis encephalitis virus Human
coronavirus Taterapox
virus Epstein-Barr
Equid
herpesvirus 9 Citrus
psorosis virus Haloarcula
phage |
BLAST |
Schizophrenia
Autoantigens reported in schizophrenia are homologous to proteins
expressed by the pathogens implicated in schizophrenia: The size of
the tags corresponds to the number of pathogen hits for each antigen |
Autoantibodies in schizophrenia from
:
Viral or pathogen homologues are tag clouded in blue: Varicella = Herpesvirus
3 |
|
CHRNA7 Rubella
Rhinovirus
Toxoplasma
Herpesvirus
3 Borrelia
Herpesvirus
2 Influenza
|
|
CHRM1 Herpesvirus
2 Herpesvirus
3 Borrelia
Influenza
Toxoplasma
Rhinovirus
Rubella
|
|
CHRM2 "Error occurred
while trying to set up a Blast Object from CGI context: CFastaReader: Input
not marked as defline or comment, but contains too many special characters
to be plausible data" (Too many hits saturated the NCBI server) |
|
DRD2 Herpesvirus
3 Herpesvirus
2 Influenza
Borrelia
Rubella
Rhinovirus
Toxoplasma
|
|
GRIN1 Toxoplasma
Herpesvirus
2 Influenza
Herpesvirus
3 Borrelia
Rubella
Rhinovirus
|
|
ELANEToxoplasma
Rhinovirus
Borrelia
Herpesvirus
2 Influenza
Rubella
Herpesvirus
3 |
|
OPRM1 Herpesvirus
3 Rubella
Borrelia
Herpesvirus
2 Influenza
Toxoplasma
Rhinovirus
|
|
nerve growth factorRhinovirus
Borrelia
Herpesvirus
2 Herpesvirus
3 Rubella
Toxoplasma
Influenza
|
|
HTR1A. Rubella
Rhinovirus
Herpesvirus
3 Toxoplasma
Influenza
Herpesvirus
2 Borrelia
|
|
HSP60 Influenza
Rhinovirus
Herpesvirus
2 Toxoplasma
Rubella
Borrelia
Herpesvirus
3 |
|
HSP70 (HSPA12A)Influenza
Toxoplasma
Herpesvirus
3 Rubella
Herpesvirus
2 Borrelia
Rhinovirus
|
|
HSP90 Rhinovirus
Influenza
Herpesvirus
2 Rubella
Borrelia
Herpesvirus
3 Toxoplasma
|
|
PAM/MYC Herpesvirus
2 Rubella
Herpesvirus
3 Borrelia
Toxoplasma
Influenza
Rhinovirus
|
|
S100B Toxoplasma
Borrelia
Influenza
Rubella
Rhinovirus
Herpesvirus
3 Herpesvirus
2 |
|
STRN Rubella
Rhinovirus
Toxoplasma
Influenza
Borrelia
Herpesvirus
2 Herpesvirus
3 |
|
|
DISC1(theoretical antigen as prediced by Bepipred)
|
BLAST |
|
|
DISC1 BLAST vs. all viruses (AIDS not included) BLAST |
|
|
|
DISC1 BLAST Results
vs. Influenza
Varicella
HSV-2
Rubella |
|
In the tables below each virus/pathogen (translated genome)
was BLASTed vs. the human proteome: The gene symbols are sized according
to
the number
of viral hits per protein (of vatches of 5 or more contiguous amino acids):
Together, these pathogen matches account for the products of ALL schizophrenia
susceptibility genes so far described in genetic association studies (over
600) See Schizophrenia genes |
|
HERV-W schizophrenia |
Filter schizophrenia |
|
|
Bornavirus |
DISC1 CACNA1C
ABCA13
RPS10
HAPLN2
ST7
GNB2
MAP1B involved
HSPA12A
BRPF3
MYT1L
GRIK1
CSF2RB
VGF involved
GPR109B ref
PCLO
TLE3
MCTP1 ref
DMTF1
PER1
RORA ref
VIP ref
SCN8A
ODZ4
GABRE
FAT4
DOCK9 ref
FABP7
BASP1 implicated
FXYD6
SEL1L3
ROR1 ref
NXN
ATP2A2 ref
SLITRK2 ref
GABRP
MCHR1
NOVA1
SPTAN1
ASTN1
STXBP1
SLC6A2
KCNN3 ref
SYN2
GRIN3A
COX2
CACNA1E
FABP3
NRG1
NFIA
UGGT2
NCKAP5
TMTC4
ANK3
DGKH
GRIN2B
GRM2
DGKI ref
CHRNA7
ATP8B3
ZNF804A
CUX2 ref
NTNG2 implicated
UACA
FAAH ref
CNTNAP5
COX1
XBP1
NALCN
STK24
CSNK1E
ND3
MDGA1
DPY19L3 ref
ND5
c18orf1
ARNTL ref
TCF7L1
GRIN2A
VIPR2 ref
INPP1 ref
GABRQ
CHRNA10
IMPA2
COX3
THOC1
CTNNA2
SORCS2
GARNL3
FBN1
DPP10
GRIN2A
KDELC1 ref
ARNTL2
DHRS4
GPR125
PER3
CCDC149
PDLIM5
DSEL
ZDHHC8
VAPA
NPAS3
TDO2
ST8SIA5
ADCYAP1
GABRA5
RORB
ADRBK2
PRODH
WNT2B
CTSF
YWAH
UBAC2
GPR18
ND4L
NDUFV2
ND4
JAM3
NCS1
ARNT2
RTN4
TSPAN8
SLC17A6
FZD2
MC5R
ND1
NAPG
SLC17A7
DNAJC3 |
9946 |
Filter schizophrenia
Red genes have also been
implicated in Bipolar disorder |
Seroprevalence
in adult schizophrenics |
HSV-2 |
|
14088 |
|
|
Filter schizophrenia |
Maternal
infection identified as a risk factor in schizophrenia |
Influenza |
|
4224 |
Filter schizophrenia |
Maternal
infection identified as a risk factor in schizophrenia |
Rhinovirus |
EGR3
GRM3
CABIN1
ABCA13
DRD1
ITIH3
JARID2
DBH
GRIN2A
FXR1
GRIA1
MC5R
PADI2
DRD2
GNB1L
ORC3L
KCNH2
UHMK1
SIL1
MCHR2
GRM4
ZNF804A
RELN
GRIA3
DISC1
DKK4
DRD5
RPGRIP1L
NOS1AP
ADCYAP1
POM121L2
ADSS
PDE7B
DGKI
NDEL1
HSPA12A
ASTN2
PPP3CC
IL1A
MYH9
NOTCH4
INTS6
SP4
VRK2
GRM5
ESR1
NRG3
PB1
TMEM108
FZD3
PFN4
CHL1
AK1
GRIA4
ACSL6
DGCR5
CLOCK
CACNA1B
PNPO
SPARCL1
MUTED
OPCML
ZDHC8
MAP4
DAOA
NUMBL
CHRNA7
ND2
SLC1A6
CHRM5
SYN3
PTBP2
COX1
ARHGEF10
PK3C2G
DAO
GNL3
SYT11
TSPAN8
MAPK14
GRIN2D
HTR7
SLC17A7
CIT
LIF
ST8S1A2
CSF2RA
PDE4B HTR2C
ASTN1
HIST1H2BJ
HTR1A
NPAS3
SYN2
MCTP2
APOL2
NPTN
TXNDC5
PLAA
SLC1A3
DGCR6
FEZ1
DRD3
EGR4
SGCR6
CHRFAM7A
CTNND2
C10orf120
ANK3
HRH2
CLINT1
PRSS16
HTR2A
MRCL3
MRLC2
DLX1
FGF14
DISC2
PNPLA8
TH
GABRP
COMT
GRM7
GLRA2
MICB
PCQAP
DRD4
ARVCF
GRIA2
PDLIM5
OPRM1
SLC6A5
CNP
CLDN5
CHI3L1
BRD1
CCKAR
HOMER1
NRXN1
GRIK3
SLC1A4
DPYSL2
HTR6
ENO2
GNPAT
SULT4A1
ABCA1
TDO2
MCHR1
PLA2G4C
GABRB2
TAAR6
IMPA2
GABBR1
SLC18A2
ND4
KPNA3
CSF2RB
CACNA1C
NOS1
RAPGEF6
NRG1
NDUFV2
BTN3A1
ANKK1
MACF1
DGCR2
MLC1
MAP6
MAG
SHISA5
MDGA1
PRODH
RGS4
GFRA3
AHI1
ALDH3B1
ARHGAP18
ZBED4
NTF3
GABRA1
CTLA4
ZNF184
SLC17A3
PPP1R1B
SYNFAP1
MYT1L
SMARCC1
FABP7
GRIN1
ADAM12
SIRT5
PCM1
CJN2
SYNGR1
HOMER2
|
5260 |
|
Maternal
infection is a risk factor in schizophrenia |
|
Rubella |
GABRA1 HTR1A CSF2RA ERBB2 MEGF10 ERBB3 NDE1 HIST1H2AGA12A GNB1L TXNDC5 REPGEF6 ASCL6 NRG1 DRD4 SHISA5 ZNF804A ADCYAP1 JARID2 FXYD6 BTN2A2 TSNAX DAOA NEUROG1 SLC6A5 NDEL1 FZD3 RELN HTR5A FABP7 SYNGR1 HTR2A PCM1 FBXL21 NRXN1 SLC18A2 CHRNA7 NUMBL ARVCF GRIN2A HTR6 ALDH1A2 MUTED NOS1 GABRP GNAL SPARCL1 TSPO ND2 CCDC60 YWHAE KCNH2 DRD1 MLC1 CSPG5 PLXNA2 MYT1L NTNG2 MCTP2 GPC1 DAO VRK2 CCKAR ASTN2 DRD2 RTN4 DTNBP1 NDUFV2 CYTB SLC1A3 PPP3CC FXR1 GRM5 ASTN1 GRIN2D GRM7 PDE4B MICB AK1 PEMT PTBP2 SRR KCNN3 KPNA3 GRM3 GRID1 ARHGEF10 PLA3G4C NRG3 SYT11 EGR2 TRAF3IP1 MPZL1 CSF2RB GABRB2 GRIA4 GCLM SMARCC1 GRIK3 NTNG1 BDNF TH HRH2 ADAM12 PCDH8 MAG RTN4R ZNF74 YWHAZ NPTN ATP6 DRD3 SLC17A1 GRIA3 CHN2 HTR7 GFRA1 ANK3 GRM4 TSPAN8 GABBR1 CHRM5 PER1 TUBA8 IMPA2 ARHGAP18 NRGN MYH9 ENO2 HIST1H2AG NTF3 CABIN1 ERBB4 SIRT5 BRD1 HOMER2 HOMER1 SYNGAP1 GRP78 PDE4D PPP1R1B HTR2C SYN2 TAAR6 ALDH3B1 SLC1A4 SP4 HIST1H2BJ KREMEN1 SLCO6A1 TPH1 RPGRIP1L HIST1H2AH CLOCK PRSS16 PADI2 NOS1AP GRIN1 PDLIM5 DGCR2 MDGA1 CACNA1C ADSS GNL3 ZDHHC8 SYN3 CDKN2A MAP6 DGCR6 PRODH PLAA DISC1 KMO AHI1 ERBB1 MAP4 IL1A OPRM1 DRD5 COMT UFD1L NPAS3 UHMK1 NOTCH4 SNAP29 MAPK14 QK1 MC5R RGS4 POM121L2 DKK4 FGF14 SLC17A3 DBH FEZ1
|
9452 |
|
Prenatal
infection is a risk factor in schizophrenia |
Filter schizophrenia |
Varicella |
|
12574 |
|
Associated
with schizophrenia in adulthood |
Filter
schizophrenia |
|
Borrelia Burgdorferi |
|
17109 |
Tick
infestation and Borrelia associated with schizophrenia
Schizophrenia |
Toxoplasma Gondii |
CCDC60 TAAR6 TSNAX ALDH3B1 NEUROG1 PRODH PDLIM5 COMT MAG GFRA1 SLC1A3 GABRP MDGA1 SLC6A5 DISC1 RELN MCTP2 FZD3 NOS1 DRD2 CHRM5 CSPG5 CACNA1C CHRNA7 DBH NPAS3 SLC17A1 ZDHHC8 HIST1H2BJ GRM7 AHI1 MYT1L PPP3CC SLC17A7 HSPA12A PADI2 DAO HIST1H2AH FABP7 SHISA5 PER1 SYNGAP1 PCDH8 SLC17A3 ZNF74 CSF2RB DRD1 CCKAR YWHAZ KREMEN1 SYN2 SRR GNAL ARHGAP18 GRID1 DRD5 HIST1H2AG HOMER1 GABRA1 MYH9 BTN3A1 KMO FXYD6 MC5R SP4 MAP6 SLC18A2 NTNG2 ATP6 NUMBL SPARCL1 TH TSPAN8 KCNN3 ZNF804A ADAM12 DGCR2 IL1A DTNBP1 POM121L2 ERBB4 SNAP29 ADCYAP1 CHN2 GRIN2C TSPO PDE4B JARID2 ERBB2 FEZ1 GRIA4 ASTN1 MLC1 HTR6 UHMK1 TPH1 SYT11 FBXL21 HTR2A ADSS HOMER2 ERBB3 PLAA TUBA8 MUTED VRK2 DRD4 ALDH1A2 PEMT MAP4 DAOA NDE1 HTR1A HTR7 CLOCK PDE4D NRXN1 GNL3 MICB MEGF10 GRM3 SYN3 SLCO6A1 NOTCH4 DLX1 ASCL6 GNB1L GRIN2A HTR5A QK1 PRSS16 PLA2G4C SYNGR1 UFD1L KPNA3 ANK3 TXNDC5 GRIA3 MAPK14 OPRM1 BTN2A2 GRIN2B GRIN1 HRH2 KCNH2 RAPGEF6 CYTB CSF2RA PCM1 CABIN1 DRD3 ARVCF GRP78 HTR2C NRG1 ND2 YWHAE MPZL1 GRIK3 AK1 PLXNA2 NDEL1 PPP1R1B NTF3 GRIN2D DGCR6 FXR1 SIRT5 GABBR1 DKK4 GRM4 IMPA2 TRAF3IP1 RGS4 GCLM GRM5 NDUFV2 ARHGEF10 SMARCC1 PNPO NPTN NRG3 ASTN2 NOS1AP EGR2 FGF14 GABRB2 ENO2 PTBP2 NTNG1 CDKN2A BRD1 |
11458 |
|
Associated
wiith schizophrenia in adulthood
Filter Schizophrenia |
Bipolar disorder |
ATPA), glutamic acid decarboxylase-65 (GAD65A),in progress |
|
|
|
|
Bornavirus |
|
|
|
Bipolar |
IMPA2 NRG1 PCLO PER1 SYNGR1 TPH1 |
20275 |
|
|
Bornavirus
serpositivity and presence in brain in bipolar disorder |
|
|
HSV-2 |
|
?
Schizophrenia 63
Bipolar disorder susceptibi;ity gene products with homology
to HSV-2 proteins ABCA13 ANK3 ASTN2 BRD1 CABIN1 CACNA1C CDKN2A CHRNA7 COMT CSF2RB DAO DAOA
DGCR6 DISC1 DRD1 DRD2 DRD3 DTNBP1 FABP7 GABRA1 GABRB2 GNB1L GNL3 GPR78
GRID1 GRIN1 GRIN2A GRM3 GRM4 GRM7 HIST1H2BJ HTR2A HTR5A HTR6 IMPA2 MC5R
MLC1 NDUFV2 NOS1AP NPAS3 NRG1 NRXN1 PDE4B PDLIM5 POM121L2 PPP3CC RELN
RGS4 RPGRIP1L RTN4R SLC18A2 SNAP29 SP4 SYN3 SYNGR1 TAAR6 TH TSNAX TSPAN8
TUBA8 UFD1L ZDHHC8 ZNF74 ZNF804A
|
|
|
|
|
There
is considerable overlap between the genes involved in bipolar disorder
and schizophrenia so the schizophrenia search filter also returbed
a number of Bipolar disorder related gene products |
Rubella |
|
64
Bipolar disorder susceptibi;ity gene products with homology
to Rubella proteins ABCA13 ANK3 ASTN2 BRD1 CABIN1 CACNA1C CDKN2A CHRNA7
COMT CSF2RB DAO DAOA DGCR6 DISC1 DRD1 DRD2 DRD3 DTNBP1 FABP7 GABRA1 GABRB2
GNB1L GNL3 GPR78 GRID1 GRIN1 GRIN2A GRM3 GRM4 GRM7 HIST1H2BJ HTR2A HTR5A
HTR6 IMPA2 MC5R MLC1 NDUFV2 NOS1AP NPAS3 NRG1 NRXN1 PDE4B PDLIM5 POM121L2
PPP3CC RELN RGS4 RPGRIP1L RTN4R SLC18A2 SNAP29 SP4 SYN3 SYNGR1 TAAR6 TH
TSNAX TSPAN8 TUBA8 UFD1L ZDHHC8 ZNF74 ZNF804A |
|
|
Filter schizophrenia also returns Bipolar genes |
|
Not
well studied compared to schizophrenia, but scattered case and antibody
reports (very) |
Varicella |
Ditto |
64
Bipolar disorder susceptibi;ity gene products with homology
to Varicella proteins ABCA13 ANK3 ASTN2 BRD1 CABIN1 CACNA1C CDKN2A CHRNA7
COMT CSF2RB DAO DAOA DGCR6 DISC1 DRD1 DRD2 DRD3 DTNBP1 FABP7 GABRA1 GABRB2
GNB1L GNL3 GPR78 GRID1 GRIN1 GRIN2A GRM3 GRM4 GRM7 HIST1H2BJ HTR2A HTR5A
HTR6 IMPA2 MC5R MLC1 NDUFV2 NOS1AP NPAS3 NRG1 NRXN1 PDE4B PDLIM5 POM121L2
PPP3CC RELN RGS4 RPGRIP1L RTN4R SLC18A2 SNAP29 SP4 SYN3 SYNGR1 TAAR6 TH
TSNAX TSPAN8 TUBA8 UFD1L ZDHHC8 ZNF74 ZNF804A |
|
|
|
|
|
Rhinovirus |
|
63
Bipolar disorder susceptibi;ity gene products with homology
to Rhinovirus proteins CIT CLDN5 CNTNAP2 DGKI PRSS16 TDO2 ANK3 ASTN2 CABIN1 CACNA1C CDKN2A CHRNA7
COMT CSF2RB DAO DAOA DGCR6 DRD1 DRD2 DTNBP1 FABP7 GABRA1 GABRB2 GNB1L
GNL3 GPR78 GRID1 GRIN1 GRIN2A GRM3 GRM4 GRM7 HIST1H2BJ HTR2A HTR5A HTR6
IMPA2 MC5R MLC1 NDUFV2 NOS1AP NPAS3 NRXN1 PDE4B PDLIM5 POM121L2 PPP3CC
RELN RGS4 RPGRIP1L RTN4R SLC18A2 SNAP29 SP4 SYN3 TAAR6 TH TSNAX TSPAN8
TUBA8 UFD1L ZDHHC8 ZNF74 ZNF804A
|
|
|
|
|
|
T.Gondii |
|
|
|
|
|
63
Bipolar disorder susceptibi;ity gene products with homology
to T.Gondii proteins
ABCA13 ANK3 ASTN2 BRD1 CABIN1 CACNA1C CDKN2A CHRNA7 COMT CSF2RB DAO DAOA
DGCR6 DISC1 DRD1 DRD2 DRD3 DTNBP1 FABP7 GABRA1 GABRB2 GNB1L GNL3 GPR78
GRID1 GRIN1 GRIN2A GRM3 GRM4 GRM7 HIST1H2BJ HTR2A HTR5A HTR6 IMPA2 MC5R
MLC1 NDUFV2 NOS1AP NPAS3 NRG1 NRXN1 PDE4B PDLIM5 POM121L2 PPP3CC RELN
RGS4 RPGRIP1L RTN4R SLC18A2 SNAP29 SP4 SYN3 SYNGR1 TAAR6 TH TSNAX TSPAN8
TUBA8 UFD1L ZDHHC8 ZNF74 ZNF804A |
|
|
|
|
|
Cervical Cancer |
|
|
|
|
|
|
|
|
|
|
|
|
|
Human papillomavirus RTRX7 NC_004761.1| |
|
TG |
HPHP |
None |
|
632 |
|
|
|
Human papillomavirus RTRX7 NC_004761.1| |
|
Cervical cancer |
Cervical cancer oncogenes and other growth and cancer related genes |
4777 |
Chronic fatigue and prostate cancer |
|
|
|
|
|
|
Xenotropic MuLV-related virus VP62 NC_007815
XMRV |
TG |
HP |
None |
Prostate cancer related proteins and mitochondrial respiration
SRCAP |
284 |
|
|
AIDS |
Neuro |
|
|
|
|
|
|
HIV-1 |
|
TG |
|
Immune |
C3 C4A C4B CCR2 CXCL3 CXCR4 CD44 CD288 FCGR2B HLA-F IDO2 IRF9 ITGA4 LILRB2
LY96 MOG NCR1 TCRB TLR5 |
5131 |
Huntington's disease, spinocerebellar ataxias, Kennedy
disease |
|
PolyQ
(25aa) |
VBYF P |
None |
Aspergillus niger Candida albicans Cryptococcus neoformans
Lactococcus
Neurospora crasse Saccharomyces cerevisiae Vibrio |
1983 |
|
|
Parkinson's disease |
|
|
|
|
|
|
Coronavirus |
Ref |
TG |
HP |
Parkinson
Those with evident relevance (PD genes , dopamine , growth factors, free
radical, glutathione are highlighted in blue) |
|
21677 |
|
|
HSV-1 |
|
Parkinson |
|
46422 |
Cystic fibrosis |
Bacterial
infections particularly staphylococcus and pseudomonas determine life
expectancy in cystic fibrosis
Viral
infections are also common determinants of severity |
Mutant
CFTR |
VP |
Viruses |
|
151 |
|
BP |
Bacteria |
|
111 |
BP |
Staphylococcus
or Pseudomonas |
|
113 |
Rhinovirus |
|
|
|
None |
|
xxx |
HIV1 |
|
TG |
HP |
None |
|
371 |
Influenza A |
|
|
|
Alzheimer |
|
xxx |
Influenza A |
|
|
|
Diabetes |
|
xxx |
Influenza A |
|
|
|
Schizophrenia |
|
xxx |
Lung cancer |
|
|
|
|
|
|
|
|
Oncogene 1 |
|
|
|
None |
Lactococcus phage Anticarsia gemmatalis nucleopolyhedrovirus Human immunodeficiency
virus 2 Epizootic haematopoietic necrosis virus Bacillus phage Pseudomonas
phage Hepatitis C lumpy skin disease virus Aeromonas phage Influenza B virus
Lactobacillus phage Human herpesvirus 2 Hepatitis E Human adenovirus 4 Human
coxsackievirus A10 Enterobacteria phage Streptococcus phage Human echovirus
30 Staphylococcus phage 42E Hepatitis B Marseillevirus Influenza A virus
Vibrio phage Human immunodeficiency virus 1 Human enterovirus B Human echovirus
18 Listeria phage Human herpesvirus 8 Human rhinovirus 81 Salmonella phage
Clostridium phage Human herpesvirus 2 Human T-lymphotropic virus 1 Klebsiella
phage KP15 Human herpesvirus 5 Human poliovirus 1 Norwalk virus Infectious
bronchitis virus Human herpesvirus 4 Bacteriophage P2-EC5 Human papillomavirus
type 112 Human enterovirus 76 Human coronavirus HKU1 human herpesvirus 4
Human adenovirus 11a |
134 |
Autism |
|
|
|
|
|
|
Measles |
MMR
apart, measles antibodies have been found in the sera of autistic patients |
|
|
|
|
xxx |
|
|
Mumps |
Almost
exclusively MMR papers |
|
|
|
BPTF IGSF10 MAN2A1 KIAA1370 ARFGAP2 SOCS4 C1orf159
ADRBK2 EFR3A ADRBK1 VCL CHD3 GPR15 PHLDB3 XIRP2 EMID1 STON1 FCRLB ZNF483
PCDH15 ZNF473 PLA2G4F ERCC1 MCM10 ZNF473 LRRC37A LOC100288229 KDM5C KDM5D
LANCL2 KIAA0226 C10orf140 LRRC37A2 LRRC37A SYNE1 PISD LCLAT1 ST5 GTPBP6
LRRC43 PRPF8 PPP1R12C IL7R BOC KIAA0907 ITF88 PRPF8 SNX7 ENTPD1 FNDC7 DNHD1
TAF1C ABCD4 ELP3 OGN ARNTL CCT6A CDC14A UBA6 TAF1C CDR1 BRD7 PLA2G6 C9orf93
LOC645202 RRBP1 FUT6 MYO3A OR2A5 ZNF358 KRTAP25-1 COL6A3 NEK9 ITF88 KATNAL1
PRAMEF23 BDP1 WDR11 MOSC2 BDNF ABCA6 SRP58 CDC40 MAPK7 PGM2L1 BRAF ZNF711
TBC1D30 EEA1 ZNF658B TBC1D30 EVPL PADI1 ERCC5 NUP160 PIK3CB NFAT5 NXF5 SCN9A
FREM2 MNT ZNF205 ABI3BP VPS39 STYXL1 NLRP9 HCN3 HCN1 SFRS18 PRRG1 NLRP9
USP6 NPHP3 ABCC11 HCN3 RIMS2 PCNT YY2 PARL MLLT1 HCN4 DGKB HMHA1 ANKLE1
TLR4 TMEM101 NALCN SSR1 KIF18A TANK GREB1L CCDC87 GPR39 IPO9 CHPT1 PAEP
MDN1 PRSS48 MRGPRX1 SLC36A3 KRT36 DDX52 OR2K2 GTF2F2 ABCA13 PRUNE2 TTN CACNA1C
TSNAX LDLRAD2 CCNI ANGEL2 SPRED2 STAG2 EPRS BCKDHA RPRD2 POC5 EFEMP2 DMXL1
ESYT1 LIFR IFIH1 RMIL LAMC3 DCLK2 GRK4 GNL3 NPHP1 CHRM4 DCLK2 MYSM1 PSD4
GRM4 MBD6 ACTRT1 RPRD2 NUF2 TMC6 LCE1D TLN1 |
270 |
|
|
|
|
Polyomavirus |
Observed
in the brains of Autism sufferers |
|
|
|
|
172 |
|
|
Rubella |
Autism
has often been observed in congenital rubella |
|
|
|
|
To
do |
|
|
Whole Genome BLASTS: No filters. These provide the
most homologous human proteins to the virus |
|
Circovirus |
|
|
xxx |
|
|
Epstein Barr |
Cancer
MS |
|
xxx |
|
|
Hepatitis A |
|
|
244 |
|
|
Hepatitis B |
|
|
168 |
|
|
Hepatitis C |
|
|
334 |
|
|
Hepatitis D |
|
|
607 |
|
|
Hepatitis E |
|
|
642 |
|
|
|
|
HERV-W
No Filter |
|
|
|
HIV-1 |
A large number of these genes are related
to the immune system
See this
page for in depth analysis AGPAT1 ALG8 ASXL3 ATRN BIK BIRC7 BRI3BP BST1 BTN2A2 CCDC39
CDH3 CHD9 CKAP5 CLASP2 CNBP CNPY3 CTSA DCBLD2 DCHC1 DNPEP DSF2 DSG3 DSPP
E2F4 ELOVL1 ERPL1 ERVK2 ERVK5 ERVK6 EYS FAT3 FLRT2 FXR2 GABBR2 GANC GDPD2
GHDC GOLGA2B GPR61 HTRC5B KAZALD1 ING3 JPH3 KBTBD11 KLHDC5 KLRAQ1 KRTAP4-6
LCN8 LDLR LRP8 MAGI1 MBOAT7 MLC1 MOCOS NAA15 NAF1 NAPIL3 NCRNA00238 NOTCH4
NUMA1 NYNRIN OBSCN OTOF PAQR6 PKD1L1 PLEK PLXNA1 POK7 POK17 POLERTNK2
RIPK3 SCAF1 SLFNL1 SLAMF7 SLC27A3 SHQ1 SMARCAL1 SRRM2 STEAP2 STRC STRCP1
SUN2 SYNE2 TMEM53 TMEM229A TMUB1 TNRC18 TTBK1 UBXN8 VWA3B ZCCH8 ZCCHC10
ZCCHC13 ZDHHC11B ZHDC
- CHANNELS
- CYTOKINES AND RELATED
- CIAPIN1 CXCL16 IL18RAP IL21R LTBP3 TGFB1 TRAF6
- DNA REPAIR
- HLA; IMMUNOGLOBULIN RECEPTORS AND RELATED
- CD300A HLA-A HLA-B HLA-C HLA-F HLA-H IGSF1 LILRB1 LILRB2 MICA
SEMA4B SHBG
- INTEGRINS AND ADHESION
- CELSR2 ITGA5 ITGB4 PDCHAC2 PCDHGA12
- SIGNALLING
- PLA2G2E PLA2G10 PLA2G15 PLBD1 PTPRE SH3TC1
- HAEMATOPOESIS AND WHITE BLOOD CELL
- GROWTH FACTORS AND RELATED
- EFNA4 FSHB GDF7 GDF10 NRG2
- LYSOSOME
- PROTEASE AND RELATED
- TRANSPORTERS
- ABCA1 ABCC2 SLC2A13 SLC6A5 SLC22A23 SLC24A3 SLC27A3 SLC27A5 VAMP4
- OLFACTORY AND TASTE RECEPTORS
- OR4E2 OR13A1 OR56A4 TAS2R12 VN1R1
- UNKNOWNS
- C1orf101 C13orf36 C14orf49 FAM90A1 FLJ33534 LOC646513 LOC283174
LOC645277 LOC645277 LOC652460 LOC100288963 LOC100287975 LOC100292541
LOC100288650 LOC100293879 LOC100133479 LOC100289316 LOC100134067
LOC100286959 LOC100131738 LOC100288635
|
371 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
HSV-1
|
|
221 |
HSV-2 NC_001798
BLAST |
|
Cytomegalovirus
HHV-5 Note the many chemokine receptors
BLAST |
ADRA1B RMND5B F2RL2 MDGA2 LOC100129098 SEMA5A CRYZL1 FNBP1 GNRR2 FCHO1 NUP155 NTN1 GPR109B FPR2 TMEM38A SBF1 POLA1 TMEM20 UNC5B SBNO2 SSTR5 MAML1 CCR5 HMCN2 BTNL9 SON KRTAP12-3 APOB48R GPR81 CCDC24 HMX1 CYSLTR2 CMKLR1 GOLGB1 FPR1 CCRL2 NEURL3 PTPN23 BTN2A2 GLIPR2 CCR9 CX3CR1 C10orf95 CCR10 GPR114 GPR17 GPR32 C16orf54 C2CD4A CGNL1 C21orf56 CCR3 GPR68 FAM47B P2RY13 IPO9 HAGHL CCBP2 HEPACAM AGTR1 FBXL19 LRRC59 FGF2 MARCH9 SLC22A25 GPR112 DEF6 GLIS1 XCR1 PTPN3 SSTR4 MTRF1L PRPF38A CXCL3 ZNF584 SSTR2 SRSF5 NIN PHLDB2 SCAND2 GATA4 FAM84A LUC7L MUC17 MINT ADRA1A PCDHA2 PYY HEXDC FADS6 AKAP8 TRIM3 F2R SMPD4 ELN AGTR2 SYNPO UBQLN4 OVOL1 KR123 PKP3 MAPK8IP2 SPEN SSTR3 GPR34 OXA1 FAD36 LOR TAS2R19 TPBG CCR7 CXCR1 SOD2 DEFB126 CCR1 LAMA2 ARHGAP29 SRRM1 SUCNR1 PCDH1 TNFRSF14 OPRM1 CDCD4B LPAR6 LAMB2 CDT1 GPR109A GPR174 LOC100507746 LMTK3 SRRM2 P2RY6 QDC1 CXCR2 GRIK5 E2F4 HTR4 CYSLTR1 1.14.18.1 C8A GPR182 ALDH3B2 UNG TPRN OR13C8 BDKRB2 PTAFR CRB2 ZMYND19 MLYCD TTC37 CCDC88C CLEC11A ADRB3 BMC1 POLD1 MAD2 PRPF38A CEPT1 CARNS1 CCDC34 GPR35 TUBB3 LRRC8B MC1R CIT INPP5J ACTN4 CCDC88C CXCR3 FER1L4 CXCR5 GPER CXCL10 ATRNL1 CCR2 CCR8 BRSK1 CFP RASGRP3 DED2 CXCR6 APLNR PCDHB17 GPR4 CCRL1 HOXA2 GPR55 REV3L e GPX4RNF213 BNC1 HTR1E DNL2 CDR2L CHST12 ALDH3B1 PNMAL2 KALRN KISS1R GUCY1A2 GEMIN7 PREPL MC4R TEX13A CROC CCR6 MLXIP SESN1 COX10 CABP1 CXCR4 OR4X2 LPAR4 ENAH CEP152 ZNF335 MGST3 MCHR1 TMEM52 LPAR5 TTLL3 OR6K2 HAB1 OR7D4 CCR4 FPR3 HPDL GNRHR2 GPR15 ELP2P MCHR2 |
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243 |
HTLV1 |
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HTLV2 |
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RE DO |
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Influenza |
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BLAST
202 |
Those with evident relevance to schizophrenia or Parkinson's disease are
highlighted in blue |
Norwalk virus |
Vomiting
sickness: The virus targets proteins involved in dopamine metabolism
and recapture : Dopamine is emetic |
AOC2 AOC3 CADPS2 CDCA7 CDCA7L IL4I1 KDM1A KDM1B MAOA MAOB PICK1 RNLS SLC6A2 SLC6A3 SLC18A1 SLC18A2 SLC22A2 SLC22A3 SLC29A4 SMOX SPR ST1A1 SULT1A3 SULT1A4 |
18837 |
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Human papillomavirus RTRX7 NC_004761.1 |
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632 |
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Rhinovirus |
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xxx |
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West Nile Virus |
Causes encephalitis |
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xxx |
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