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Please cite these papers and this site if using these data. Thank you

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Viral insertions

AIDS

Viral component of human proteins

PolygenicBlog on the relations between genes, risk factors and autoimmunity

 

Enhanced links to genes are provided by

Chromosomal shuffling over millions of years has broken up and fragmented the viral DNA: Short contiguous sequences are retained

Old insertions
More DNA fragmentation
Shorter viral/human consensus sequences
Greater number of viral/human matches
New insertions
Less DNA fragmentation
Longer viral/human consensus sequences
Fewer viral/human matches

HSV-1 Herpes simplex

HIV-1 AIDS

 

 

 

 

Viral Vatches homologous to human proteins can interfere with their human counterparts in a number of ways

The Norovirus/norwalkvirus causes vomiting sickness

 

The rhinovirus has a different profile: For example it is not homologous to DISC1 or Neuregulin

 

Schizophrenia susceptibility genes with homology to the rhinovirus

ACSL6 ADAM12 ADCYAP1 ADSS AGBL1 AHI1 AK1 ALDH1A2 ALDH3B1 ANK3 ARHGAP18 ARHGEF10 ARVCF ASTN1 ASTN2 BTN2A2 BTN3A1 BTN3A2 CABIN1 CACNA1C CCDC60 CCKAR CDKN2A CHI3L1 CHN2 CHRM5 CHRNA7 CIT CLDN5 CNP CNTNAP2 COMT CSF2RA CSF2RB CSPG5 CTNND2 DAO DAOA DBH DGCR2 DGCR6 DGKI DKK4 DLX1 DRD1 DRD2 DRD5 DTNBP1 EGR2 EGR3 EGR4 ENO2 FABP7 FBXL21 FGF14 FXR1 FXYD6 FZD3 GABBR1 GABRA1 GABRB2 GABRP GCLM GFRA1 GFRA3 GNB1L GNL3 GPR78 GRIA3 GRIA4 GRID1 GRIK3 GRIN1 GRIN2A GRIN2D GRM3 GRM4 GRM5 GRM7 HIST1H2AG HIST1H2AH HIST1H2BJ HOMER1 HOMER2 HRH2 HSPA12A HTR1A HTR2A HTR2C HTR5A HTR6 HTR7 IL1A IMPA2 JARID2 KCNH2 KMO KPNA3 KREMEN1 LIF MAG MAP4 MAP6 MAPK14 MC5R MDGA1 MEGF10 MICB MLC1 MPZL1 MUTED MYH9 MYT1L NDE1 NDEL1 NDUFV2 NEUROG1 NOS1AP NOTCH4 NPAS3 NPTN NRGN NRXN1 NTF3 NTNG1 NTNG2 NUMBL OPRM1 PADI2 PCDH8 PCM1 PDE4B PDE4D PDE7B PDLIM5 PEMT PLA2G4C PLAA PLXNA2 PNPO POM121L2 PPP1R1B PPP3CC PRODH PRSS16 PTBP2 RAPGEF6 RELN RGS4 RPGRIP1L RTN4R SHISA5 SIRT5 SLC17A1 SLC17A3 SLC17A7 SLC18A2 SLC1A4 SLC6A5 SLCO6A1 SMARCC1 SNAP29 SP4 SPARCL1 SRR SULT4A1 SYN2 SYN3 SYNGAP1 SYT11 TAAR6 TDO2 TH TPH1 TRAF3IP1 TSNAX TSPAN8 TSPO TUBA8 TXNDC5 UFD1L UHMK1 VRK2 YWHAE YWHAZ ZBED4 ZDHHC8 ZNF184 ZNF74 ZNF804A

When immunogenic, antibodies to the viral protein may also target the human counterparts, effectively producing protein knock down, equivalent to the effects of gene knockouts in transgenic mice

The figure below shows the antigenicity of several HIV-1 AIDS vatches as predicted by the BepiPred server : Most of the human targets belong to various components of the human immune network including:-

RIN3 FCGBP TOPORS CIAPIN1 TCF25 COL7A1 ATP6VOA2 YBX2 MLL3 USP9X ROBO1 SIRT1 PLEC SLC16A2 SLC16A2 POU2F1a PLXNB1 TBC1D15 POP1 MGAT4B CORIN CD3EAP DOCK8 ETV5 IL13RA PLXND1 ALX1 GRIP2 MLK2 PTPN2 POU2F1 ITFG3 TJP1 ZNF786 COL6A2 RET TMEM161A GK5 GBGT1 KCNAB1 LYA9 GALNS NUMA1 CHD2 TCRD PIWIL1 PRSS16 HLA PRAF2 RREB1

Highly immunogenic Vatches will generate antibodies that will also attack cells containing their human counterparts.

This is best illustrated by the effects of vaccination with the microtubule protein tau, in mice, that produces neurofibrillary tangles , tau phosphorylation and several of the pathological features of Alzheimer's disease. Viral vatches are homologous to tau (MAPT).

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein

Rosenmann H, Grigoriadis N, Karussis D, Boimel M, Touloumi O, Ovadia H, Abramsky O.

Arch Neurol. 2006 Oct;63(10):1459-67.

   

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