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hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (21)


hsa:134 ADORA1; adenosine A1 receptor
hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:552 AVPR1A; arginine vasopressin receptor 1A
hsa:1268 CNR1; cannabinoid receptor 1 (brain)
hsa:1394 CRHR1; corticotropin releasing hormone receptor 1
hsa:1813 DRD2; dopamine receptor D2
hsa:1814 DRD3; dopamine receptor D3
hsa:2557 GABRA4; gamma-aminobutyric acid (GABA) A receptor, alpha 4
hsa:2568 GABRP; gamma-aminobutyric acid (GABA) A receptor, pi
hsa:9340 GLP2R; glucagon-like peptide 2 receptor
hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2915 GRM5; glutamate receptor, metabotropic 5
hsa:3061 HCRTR1; hypocretin (orexin) receptor 1
hsa:3352 HTR1D; 5-hydroxytryptamine (serotonin) receptor 1D
hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A
hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C
hsa:3361 HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A
hsa:4923 NTSR1; neurotensin receptor 1 (high affinity)
hsa:4985 OPRD1; opioid receptor, delta 1
hsa:6869 TACR1; tachykinin receptor 1

hsa04728 Dopaminergic synapse - Homo sapiens (human) (12)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48)
hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:1813 DRD2; dopamine receptor D2
hsa:1814 DRD3; dopamine receptor D3
hsa:2778 GNAS; GNAS complex locus
hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1
hsa:6571 SLC18A2; solute carrier family 18 (vesicular monoamine), member 2
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa04020 Calcium signaling pathway - Homo sapiens (human) (10)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:552 AVPR1A; arginine vasopressin receptor 1A
hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus
hsa:2915 GRM5; glutamate receptor, metabotropic 5
hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A
hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C
hsa:3361 HTR5A; 5-hydroxytryptamine (serotonin) receptor 5A
hsa:4923 NTSR1; neurotensin receptor 1 (high affinity)
hsa:6869 TACR1; tachykinin receptor 1

hsa04540 Gap junction - Homo sapiens (human) (6)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:1813 DRD2; dopamine receptor D2
hsa:2778 GNAS; GNAS complex locus
hsa:2915 GRM5; glutamate receptor, metabotropic 5
hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A
hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C

hsa01100 Metabolic pathways - Homo sapiens (human) (6)

hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5053 PAH; phenylalanine hydroxylase (EC:1.14.16.1)
hsa:5860 QDPR; quinoid dihydropteridine reductase (EC:1.5.1.34)
hsa:121278 TPH2; tryptophan hydroxylase 2 (EC:1.14.16.4)

hsa05016 Huntington's disease - Homo sapiens (human) (5)



hsa:627 BDNF; brain-derived neurotrophic factor
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2915 GRM5; glutamate receptor, metabotropic 5
hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
hsa:7350 UCP1; uncoupling protein 1 (mitochondrial, proton carrier)

hsa04730 Long-term depression - Homo sapiens (human) (5)



hsa:1392 CRH; corticotropin releasing hormone
hsa:1394 CRHR1; corticotropin releasing hormone receptor 1
hsa:2778 GNAS; GNAS complex locus
hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2915 GRM5; glutamate receptor, metabotropic 5

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (5)



hsa:9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
hsa:181 AGRP; agouti related protein homolog (mouse)
hsa:5443 POMC; proopiomelanocortin
hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
hsa:7124 TNF; tumor necrosis factor

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (5)



hsa:627 BDNF; brain-derived neurotrophic factor
hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:4803 NGF; nerve growth factor (beta polypeptide)
hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1)
hsa:4916 NTRK3; neurotrophic tyrosine kinase, receptor, type 3 (EC:2.7.10.1)

hsa04010 MAPK signaling pathway - Homo sapiens (human) (4)



hsa:627 BDNF; brain-derived neurotrophic factor
hsa:4803 NGF; nerve growth factor (beta polypeptide)
hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1)
hsa:7124 TNF; tumor necrosis factor

hsa04724 Glutamatergic synapse - Homo sapiens (human) (4)



hsa:2778 GNAS; GNAS complex locus
hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2915 GRM5; glutamate receptor, metabotropic 5

hsa04720 Long-term potentiation - Homo sapiens (human) (4)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:2915 GRM5; glutamate receptor, metabotropic 5

hsa04727 GABAergic synapse - Homo sapiens (human) (4)



hsa:2557 GABRA4; gamma-aminobutyric acid (GABA) A receptor, alpha 4
hsa:2568 GABRP; gamma-aminobutyric acid (GABA) A receptor, pi
hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)
hsa:4905 NSF; N-ethylmaleimide-sensitive factor (EC:3.6.4.6)

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (3)



hsa:4905 NSF; N-ethylmaleimide-sensitive factor (EC:3.6.4.6)
hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1
hsa:6571 SLC18A2; solute carrier family 18 (vesicular monoamine), member 2

hsa05010 Alzheimer's disease - Homo sapiens (human) (3)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:7124 TNF; tumor necrosis factor

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (3)



hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)
hsa:3630 INS; insulin
hsa:7124 TNF; tumor necrosis factor

hsa04970 Salivary secretion - Homo sapiens (human) (3)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus

hsa04910 Insulin signaling pathway - Homo sapiens (human) (3)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:3630 INS; insulin
hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (3)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:2778 GNAS; GNAS complex locus
hsa:7124 TNF; tumor necrosis factor

hsa05012 Parkinson's disease - Homo sapiens (human) (3)



hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1
hsa:6571 SLC18A2; solute carrier family 18 (vesicular monoamine), member 2
hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (3)



hsa:2890 GRIA1; glutamate receptor, ionotropic, AMPA 1
hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:7124 TNF; tumor necrosis factor

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (3)



hsa:9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
hsa:3630 INS; insulin
hsa:7124 TNF; tumor necrosis factor

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (3)


hsa:552 AVPR1A; arginine vasopressin receptor 1A
hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus

hsa04916 Melanogenesis - Homo sapiens (human) (3)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus
hsa:5443 POMC; proopiomelanocortin

hsa04912 GnRH signaling pathway - Homo sapiens (human) (2)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (2)



hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:5053 PAH; phenylalanine hydroxylase (EC:1.14.16.1)

hsa04114 Oocyte meiosis - Homo sapiens (human) (2)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:3630 INS; insulin

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (2)



hsa:2904 GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B
hsa:7124 TNF; tumor necrosis factor

hsa05133 Pertussis - Homo sapiens (human) (2)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:7124 TNF; tumor necrosis factor

hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human) (2)



hsa:2778 GNAS; GNAS complex locus
hsa:4905 NSF; N-ethylmaleimide-sensitive factor (EC:3.6.4.6)

hsa04971 Gastric acid secretion - Homo sapiens (human) (2)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:2778 GNAS; GNAS complex locus

hsa03320 PPAR signaling pathway - Homo sapiens (human) (2)



hsa:9370 ADIPOQ; adiponectin, C1Q and collagen domain containing
hsa:7350 UCP1; uncoupling protein 1 (mitochondrial, proton carrier)

hsa05152 Tuberculosis - Homo sapiens (human) (2)



hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)
hsa:7124 TNF; tumor necrosis factor

hsa00350 Tyrosine metabolism - Homo sapiens (human) (2)



hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)
hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (2)



hsa:2778 GNAS; GNAS complex locus
hsa:7124 TNF; tumor necrosis factor

hsa04210 Apoptosis - Homo sapiens (human) (2)



hsa:4803 NGF; nerve growth factor (beta polypeptide)
hsa:7124 TNF; tumor necrosis factor

hsa05146 Amoebiasis - Homo sapiens (human) (2)



hsa:2778 GNAS; GNAS complex locus
hsa:7124 TNF; tumor necrosis factor

hsa00380 Tryptophan metabolism - Homo sapiens (human) (2)



hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)
hsa:121278 TPH2; tryptophan hydroxylase 2 (EC:1.14.16.4)

hsa05168 Herpes simplex infection - Homo sapiens (human) (2)



hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48)
hsa:7124 TNF; tumor necrosis factor

hsa04144 Endocytosis - Homo sapiens (human) (2)



hsa:153 ADRB1; adrenergic, beta-1-, receptor
hsa:2869 GRK5; G protein-coupled receptor kinase 5 (EC:2.7.11.16)

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (2)



hsa:2099 ESR1; estrogen receptor 1
hsa:2778 GNAS; GNAS complex locus

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa04150 mTOR signaling pathway - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (1)

hsa:2869 GRK5; G protein-coupled receptor kinase 5 (EC:2.7.11.16)

hsa05145 Toxoplasmosis - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05110 Vibrio cholerae infection - Homo sapiens (human) (1)

hsa:2778 GNAS; GNAS complex locus

hsa04976 Bile secretion - Homo sapiens (human) (1)

hsa:2778 GNAS; GNAS complex locus

hsa05330 Allograft rejection - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05162 Measles - Homo sapiens (human) (1)

hsa:6869 TACR1; tachykinin receptor 1

hsa05214 Glioma - Homo sapiens (human) (1)

hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa00340 Histidine metabolism - Homo sapiens (human) (1)

hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04710 Circadian rhythm - mammal - Homo sapiens (human) (1)

hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48)

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (1)

hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)

hsa04140 Regulation of autophagy - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05140 Leishmaniasis - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05134 Legionellosis - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05310 Asthma - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) (1)

hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa04740 Olfactory transduction - Homo sapiens (human) (1)

hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)

hsa04380 Osteoclast differentiation - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (1)

hsa:4036 LRP2; low density lipoprotein receptor-related protein 2

hsa05215 Prostate cancer - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa05144 Malaria - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (1)

hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04742 Taste transduction - Homo sapiens (human) (1)

hsa:2778 GNAS; GNAS complex locus

hsa05166 HTLV-I infection - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04972 Pancreatic secretion - Homo sapiens (human) (1)

hsa:2778 GNAS; GNAS complex locus

hsa00650 Butanoate metabolism - Homo sapiens (human) (1)

hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04744 Phototransduction - Homo sapiens (human) (1)

hsa:801 CALM1; calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19)

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (1)

hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05332 Graft-versus-host disease - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (1)

hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4)

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (1)

hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6)

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05164 Influenza A - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) (1)

hsa:5053 PAH; phenylalanine hydroxylase (EC:1.14.16.1)

hsa04612 Antigen processing and presentation - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa04360 Axon guidance - Homo sapiens (human) (1)

hsa:22854 NTNG1; netrin G1

hsa00410 beta-Alanine metabolism - Homo sapiens (human) (1)

hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa05143 African trypanosomiasis - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa05160 Hepatitis C - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human) (1)

hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (1)

hsa:3630 INS; insulin

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (1)

hsa:7124 TNF; tumor necrosis factor

hsa00790 Folate biosynthesis - Homo sapiens (human) (1)

hsa:5860 QDPR; quinoid dihydropteridine reductase (EC:1.5.1.34)