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Enhanced links to genes are provided by Last update: November 21, 2010

Supplementary Table 2:

From:- Carter C.J. Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and T.Gondii, Schiz Bull, in press, 2008

A summary of the human genes implicated in infection by various species of virus and pathogen. 

The data are a summary of association data stored at the HugeNet Phenopedia and of medline searches.

Genes also implicated in schizophrenia are highlighted in bold.

Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn, and Muin J. Khoury.  Phenopedia. HuGE Navigator.  Available at: Hugenavigator

Updates in progress	Influenza	HSV-1	HHV-6	Herpesviridae infections	Helicobacter pylori	Cytomegalovirus	Toxoplasmosis
No genetic studies found for Rubella	MBL2, IL10 1 HLA-DRB1 2 IL6 3,4	APOE 5 DEFB1 Tesse et al, 2009 HLA-B  6 IL10 7 MICB 7 IL18RAP 8 LTF 9 KIR2DL2/ KIR2DS2  10 TLR2  11 MBL 12	TP53 13 MHC2TA  14	APOE 15 CCR5 16 CTLA4 17 HLA-DRB1 18 IL4 19 19,20 IL10 21 TNF 22 23 IL1A, TGFB1 24 MHC2TA 14 HLA-A 25 IFNG 26 SLC11A1 27 IL8RB, IL13 28. IL6, IL12A 19 FCGR3A 29	CD14 Virta et al, 2008	DEFB1 Tesse et al, 2009 HLA-B 30 HLA-DRB1 31  IL1RN 32 IL10 33 IL12B 34 IL18, IL18R1, IL18RAP 8  TNF 34 MBL, TLR4 35,36 TLR2 37 GJB2 38 MICA 39	HLA-DRB1 40 ABCA4 Jamieson et al, 2009 CCR5 Ashton et al, 2002 COL2A1 Jamieson et al, 2009 IFNG Memorias et al, 2009 IL10 Cordeiro et al, 2008 TLR9 Memorias et al, 2009 HLA-DQB*0402 and DRB1*08 in HIV infected patients Habegger et al, 2005
Schizophrenia-related genes: N and %	3 / 4 (75%)	5 / 10 (50%)	1 / 2 (50%)	7 / 18 (39%)		9 / 14 (64%)	1/1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

A linkage study has identified a marker (D21S409) at 21q21.1 related to HSV-1 infection ⁴¹ . This chromosomal region has also been implicated in schizophrenia ^42,43,44 .

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Last update: November 21, 2010