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Toxoplasmosis affects many of the world's population : During its life cycle the parasite interacts with a number of host proteins and alters the expression of multiple messenger RNAs: This page links to a number of pages relevant to this host pathogen interactome

Within this interactome there are numerous susceptibility genes for various diseases ( see index for the susceptibility gene dataset for each disease) . KEGG pathways were reanalysed for each overlapping dataset (i.e. genes common to the interactome and the disease in question).

There are a large number of human genes in the T.Gondii/host interactome ( 2791) and 26846 genes in the human genome (at the time of writing): Any other dataset would be expected to contain 2791/26846 interactome genes (~ 10.3%). Similarly, for N susceptibility genes, N/26846 would be expected to appear in the T.Gondii interactome. All of these datasets, with the exception of X and Y were significantly enriched in T.Gondii related genes and the enrichment values and P values (chi squared) are shown for each case.

KEGG pathways for the susceptibility genes common to the T.Gondii interactome in :-

From:- Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders J.Pathogens, 2013

  1. ADHD: Attention deficit hyperactivity disorder: P = 8.01204E-05 : Common genes ABCB1 ACAT1 ADAM10 ADRA1A ATM C4B CDH13 CHD6 CHL1 CHN2 CREB5 DDC DNM1 DRD2 DRD4 DRD5 EMP2 EREG FADS1 FADS2 FZD7 HK1 HNMT HTR1D LPL MAN2A2 MAOA MAP1B NAPRT1 NDE1 NOS1 NPY PER2 PPM1K RIT1 SLC1A3 SLC6A3 STIP1 SULF2 SYN3 TACR3 TRPT1
  2. Autism P = 0.013 Common genes: ABCA13 ABCB1 ADA ALCAM ANXA1 APBB2 ARRDC3 ATOH8 C1orf107 C3orf31 C4B C8orf83 CACNA1G CALD1 CCL1 CCL20 CD38 CD44 CDH13 CDH20 CDKL5 CHD6 CIT CKAP4 COL6A1 CREB5 CSF2RB CTSD CXADR CXCR4 DDAH1 DDR2 DHRS3 DLG4 DLX2 DPP10 DPYD DRD3 EGR2 EPAS1 ESR1 ETS1 EYA1 EYA4 F13A1 FABP5 FABP7 FAM129B FLT1 FOXN3 FYN GABRB3 GCH1 GPATCH3 GPC5 GPR176 GRIN2A GRK5 GSTM1 HDAC9 HLA-A HLA-C HNRNPH2 ICOS IFI27L1 IFIT3 IGFBP7 IL17RA IRF8 ITGA2 ITGA4 ITGA9 ITGB3 ITGB7 JAG1 KALRN KCNMA1 KIAA1586 LASS6 LGR5 LPIN1 MAF MAOA MAP3K7 MAP3K8 MICAL2 MTF1 MTHFD1 MTHFD1L MYC MYO16 MYOF NBEA NETO1 NPTX1 NR2F2 NRCAM OSTF1 P2RY1 PARD6G PCDH18 PDE2A PFKP PGPEP1 PIK3CG PLA2G4A PLAUR PLN PLXNC1 PREX1 PRKCA PTGS2 PTPN1 PTX3 RAD23B RHOB RND3 RPL10 RPS29 SAFB SAFB2 SCARA3 SCN2A SDC2 SEL1L SLC6A8 SPRY2 SULF2 SYN3 TDO2 TH THAP2 TLE4 TLR4 TMEM132B TMEM135 TMEM2 TNIK TNS1 TSHZ2 ZFP36L2 ZNF397OS
  3. Alzheimer's disease P = 2.26E-41: Common genes: A2M
    ABCA1 ACAN ACE ADAM10 ADRB2 AHSG ALB APBB1 APBB2 APH1B APOC2 APOD APOE APP ARC ARSB ATP6 C4A C4B CAND1 CAV1 CCL2 CCL3 CCR2 CD14 CD2AP CD33 CD36 CD86 CDC2 CECR2 CH25H CHRNA7 COX3 CR1 CRP CSF1 CTSD CYTB DPYSL2 DRD4 EBF3 EIF2AK2 EIF2AK3 ESR1 F13A1 FAM63A FAS FDPS FERMT2 GAPDH GBP2 GRIN2B GRN GSK3B GSTM1 GSTM3 HMGCR HMGCS2 HMOX1 HSPA5 HSPG2 HTR6 ICAM1 IGF1 IL10 IL18 IL1A IL1B IL1RN IL33 IL6 IL8 INPP5D KCTD2 KLF5 LCK LDLR LMNA LPL LRP1 MAOA MEFV MMP1 MMP3 MTHFD1L ND1 ND4 NFE2L2 NLRP1 NLRP3 NOS1 NOS2 NPC2 OLR1 OTC PARP1 PCGF5 PCK1 PCMTD1 PDE9A PLAU PLD3 PLTP PPARA PPARG PSENEN PTGS2 PTK2B PVRL2 RBL1 SASH1 SCN2A SEL1L SERPINA1 SERPINE1 SGPL1 SLC6A3 SOAT1 SOD2 SSB SYN3 TAP2 TAPBPL TGFB1 TLR2 TLR4 TLR9 TNF TOMM40 TREM2 TTLL7 UBD UBE2I UCHL1 VDR ZBP1
  4. Bipolar disorder P = 5.36E-17 Common genes: ABCA13 ABCB1 AKT1 ALOX12 APOE ATF3 BCL2 BCL9 BDKRB2 BMP6 CCL2 CD276 CDH20 CIT COLEC12 CREB1 CSF2RB CTLA4 CTSH DDC DPP10 DPY19L3 DPYSL2 DRD1 DRD2 DRD3 DTNBP1 DUSP6 EGR2 EGR3 FABP7 FAM115A FKBP5 FOXN3 FYN GABRB3 GCHI GNL3 GPX3 GRIN2A GSK3B GSTM1 HK2 HNRNPC HSP90B1 HSPA5 IFNG IGF1 IL10 IL1B IL1RN IL2RB IL6 IMPA2 LAMP3 LRRC36 MAOA MCM3APAS MLC1 MMP9 MTHFD1 N6AMT1 NAP5 NCAN ND1 ND4 NOS1 NR1D1 P2RX7 PDE4B PER3 PIK3C3 PLCG1 PLSCR4 PPARD PPP3CC SCN8A SDC2 SLC12A6 SLC26A7 SNX27 SOD2 STAB1 SVEP1 SYN3 SYNGR1 TDO2 TEC TH TLE4 TNF TRPM2 TSHZ2 YWHAH
  5. Depression: P = 2.41E-13 Common genes: ABCB1 ADA ADCY3 AMPD2 APAF1 APOE CCL2 CDH13 CR1 CREB1 CSF2RB CYP1B1 DDC DRD1 DRD2 DRD3 DRD4 DTNBP1 EMP1 ESR1 FADS1 FADS2 FKBP5 FOLH1 GABRB3 GAL GMIP GSK3B HOMER1 IDO1 IFNG IL10 IL1B IL6 MAOA NOS1 NOS2 NPY P2RX7 PER2 PER3 PLA2G4A PRKCB PTGS2 SERPINE1 SIGMAR1 SLC6A3 SLFN12L SOD2 TGFB1 TNF VCAN
  6. Schizophrenia: P = 3.06E-27 Common genes: ABCA1 ABCA13 ABCB1 ADA ADORA1 ADRA1A AGAP1 ALDH1A2 ALOX12 ANXA1 APOE ARHGAP18 ARHGEF10 ATM ATP6 ATXN3 BCL9 BMP6 C3 C4A C4B CALR CAV1 CCR5 CD4 CFB CHL1 CHN2 CIT CNP CNTF CNTN1 CSF2RB CSPG5 CTLA4 CYTB DLG2 DLG4 DNMT3B DPYSL2 DRD2 DRD3 DRD4 DRD5 DTNBP1 EBF3 EGR2 EGR3 EGR4 ERBB2 ERC2 ESR1 FABP7 FLNB FOLH1 FYN GCLC GCLM GFRA3 GLG1 GNL3 GPC1 GRIN2A GSK3B GSS GSTM1 HLA-A HLA-DQA2 HOMER1 HTR3E IFNG IFT88 IGH@ IL10 IL10RA IL12B IL18 IL18R1 IL1A IL1B IL1RN IL2 IL3 IL3RA IL4 IL6 IMPA2 KLF5 LIF LPL LTA MAG MAOA MAPK14 MLC1 MMP3 MMP9 MTHFD1 MYH9 NAALAD2 NAP5 NCAN ND4 NDE1 NFKB1 NOS1 NPY NQO2 NRG2 PAFAH1B1 PAX6 PCK1 PDCD1LG2 PDE4B PDGFB PDYN PER3 PHOX2A PIK3C3 PLA2G4A PLXNA2 PNPO PPARD PPARG PPP3CB PPP3CC PRKCA PTGS2 PTPRZ1 RANBP1 RELA RHD SEPSECS SFRP1 SIGMAR1 SLAMF1 SLC12A2 SLC1A3 SLC39A8 SLC40A1 SLC6A3 SMARCA2 SOD2 SRR SYN3 SYNGR1 TCF7L2 TDO2 TGM2 TH TNF TNFRSF1B TNIK TSPO TXNDC5 UCP2 UFD1L VDR VIPR2 YWHAH
  7. Multiple sclerosis: P = 1.22E-71 Common genes: ACTN1 ANKRD55 APOC2 APOE ATP6 BCL2 C4A C5 C7 CASP8 CASP9 CAV1 CCL1 CCL11 CCL14 CCL2 CCL3 CCL5 CCL7 CCR2 CCR5 CD14 CD226 CD24 CD28 CD4 CD40 CD86 CDC37 CHUK CIITA CNTF CTLA4 CXCL10 CXCL12 CXCR4 CXCR5 CYP24A1 CYTB DDAH1 ERAP1 ESR1 FAM164A FAS FCGR3B GPC5 GRN GSK3B GSTM1 GSTM3 HLA-A ICAM1 ICOS IFI30 IFIT1 IFNG IFNGR2 IGH@ IL10 IL12A IL12B IL1B IL1RN IL2 IL2RA IL2RB IL4 IL4R IL6 IL7 IL7R IL8 IRF1 IRF8 ITGAM JAG1 LAG3 LTA MAPK1 METTL1 MIF MMP12 MMP2 MMP3 MMP9 MPHOSPH9 MX1 MYC MYH9 ND1 ND4 NDUFS5 NDUFS7 NFKBIA NOD2 NOS2 P2RX7 PDCD1 PDE4B PLCL1 PPARG PRF1 PRKCA PSMB8 PSMB9 PSORS1C1 PTAFR PTGER4 PTGS2 PTPN2 PVR RGS1 RPS6KB1 SERPINE1 SLC11A1 SLC25A36 SOCS1 SPP1 STAT1 SYN3 TAC1 TAP2 TGFB1 TNF TNFRSF1A TNFSF10 TOMM40 TRB@ TRD@ TYK2 UCP2 VDR WDYHV1 ZIC1 ZNF532
    Parkinson's disease : P = 3.81E-08 Common genes: A2M ABCB1 AKT1 APOE ATP6 B2M BST1 C17orf69 C4A C4B CD14 CTSD CYTB DLG2 DRD2 DRD3 DRD4 GALNT3 GNE GPNMB GRK5 GSK3B GSTM1 HLA-DQA2 HMOX1 HNMT IL10 IL18 IL1A IL1B IL6 IL8 INS ITGA8 LAMP3 MAOA ND1 NFE2L2 NOS1 NOS2 NQO2 NR4A2 PARK7 PARP1 PTGS2 SFXN2 SLC6A3 SOD2 TH TNF UCHL1 VDR
  8. Anorexia P = 0.091 (Non-significant) Common genes: ADORA1 DRD2 DRD3 ESR1 GRK5 HTR1D INS MAOA SLC6A3 TNF UCP1 UCP2
  9. Childhood obesity: P = 2.32E-12 Common genes: ABCB5 APOE BBS4 CRP ENPP1 ESR1 FABP4 HOXB5 IGFBP3 IL15 IL6 INS KCTD15 LPIN1 LPL MAF MMP2 PPARG PRF1 SERPINE1 TNF UCP1 UCP2
  10. Chronic fatigue: P = 0.48 (Non significant) Common genes: APOE DRD3 DTX4 IFNG IL4 MAOA MTAP PPFIBP1 SCN8A TH TNF TNFRSF1B

 

  

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