POLYGENIC PATHWAYS HOME

Recent reviews on the genetics of Schizophrenia and current theories :-

Convergence of schizophrenia-related genes:-

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Harrison PJ, Weinberger DR.Molecular Psychiatry, 2005 ,10, 40-68    Related articles

Owen MJ. Genomic approaches to schizophrenia.Clin Ther. 2005;27 Suppl A:S2-7.  Related articles

Recent advances in the genetics of schizophrenia. Hum.Mol Genet.2003 Oct 15;12 Spec No 2:R125-33. Epub 2003 Sep 2. Review. O'Donovan,M.C.; Williams,N.M.; Owen,M.J. Related articles


NMDA receptor hypofunction and schizophrenia

Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Coyle JT, Tsai G, Goff D. Ann N Y Acad Sci. 2003 Nov;1003:318-27. Related articles

Schizophrenia and plasticity
Schizophrenia as a disorder of neuroplasticity. McCullumsmith RE, Clinton SM, Meador-Woodruff JH. Int Rev Neurobiol. 2004;59:19-45. Related articles

The reduced neuropil hypothesis: a circuit based model of schizophrenia. Selemon LD, Goldman-Rakic PS. Biol Psychiatry. 1999 Jan 1;45(1):17-25. Related articles


Oligodendrocytes and schizophrenia 
White matter changes in schizophrenia: evidence for myelin-related dysfunction. Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V. Arch Gen Psychiatry. 2003 May;60(5):443-56 Related articles

Oxidative stress and schizophrenia

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S. Mol Psychiatry. 2004 Jul;9(7):684-97, 643. Related articles

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Do KQ, Trabesinger AH, Kirsten-Kruger M, Lauer CJ, Dydak U, Hell D, Holsboer F, Boesiger P, Cuenod M.
Eur J Neurosci. 2000 Oct;12(10):3721-8. Related articles

Prenatal infection and schizophrenia PUBMED