Enhanced links are provided by
Table 1 Viral vatches identified for myelin related autoantigens: In this and other tables contiguous stretches of 5 or more amino acids (vatches) are boxed. The 5 highest scoring immunogenic amino acids (P,G,D,E,S) are shaded in grey.
Jens Erik Pontoppidan Larsen, Ole Lund and Morten Nielsen. Improved method for predicting linear B-cell epitopes. Immunome Res. 2006; 2: 2.
M. Nielsen, C. Lundegaard, O. Lund, and C. Kesmir. 2005. The role of the proteasome in generating cytotoxic T cell epitopes: Insights obtained from improved predictions of proteasomal cleavage. Immunogenetics. 57:33-41.
The antigenicity index (B-cell epitope) for single amino acids as defined by the BepiPred server The top 5 scoring amino acids are marked in grey in the various tables below: Note that indices can be markedly increased, or decreased when the proteins are assembled, depending on the neighbours of each amino acid.
MBP NP_001020252 myelin basic protein isoform 1 |
GRGLSL |
ACO87999 Hirame rhabdovirus |
? |
RSGSPM |
ADE45455 Polyomavirus HPyV7 |
? |
|
PSQRHGS |
YP_073799 Human herpesvirus 7 |
Detected in MS tissue 1 |
|
IGRFFGG |
YP_143172 Acanthamoeba polyphaga mimivirus |
? |
|
PRTPPP |
JC Polyomavirus |
Seropositivity in some Multiple sclerosis patients 2 |
|
IVTPRT |
YP_002117760 Pseudomonas phage |
? |
|
GRASDY |
YP_164431 Bacillus phage |
? |
|
LDSIGR |
YP_142835 Acanthamoeba polyphaga mimivirus |
? |
|
TAHYGS |
ACZ8140 Moussavirus |
? |
|
VLGPLV |
ADA81168 Staphylococcus phage |
? |
|
LVALII |
NP_690686 Bacillus phage |
? |
|
KDQDG |
ABO87130 Hepatitis delta virus |
? |
|
ELLKDA+G |
NP_569759 Mycobacterium phage |
? |
|
FNTWT |
YP_001111042Burkholderia phage |
? |
|
CSAVPV |
AF310938 Powassanvirus NP_620108 Langatvirus |
? |
|
GLLEC |
AAW33310 Human adenovirus4 |
Associated with relapse in multiple sclerosis 3 |
|
KTSA-SIGSLC |
ABU82778 Human metapneumovirus |
? |
|
KNYQDY |
YP_002241563 Mycobacterium phage Butterscotch YP_002241480 Mycobacterium phage Troll4 YP_655259 Mycobacterium phage PBI1 |
? |
|
YQDYEY |
YP_717772 Synechococcus phage |
? |
|
PFASL-A And NFAVL |
YP_001129421 Human herpes virus 8 (Kaposi’s sarcoma virus) |
? |
|
KNYQDY |
YP_002241961 Mycobacterium phage Gumball YP_001936156 Mycobacterium phage Adjutor |
? |
|
CNP NP_149124.3| Cyclic nucleotide phosphodiesterase |
GK GK P
|
Q3KSQ2.1|KITH_EBVG RecName: Full=Thymidine kinase |
Epstein-Barr |
E EV G EL S
|
YP_223877.1| putative DNA binding protein [Lactobacillus phage phiJL-1] |
Lactobacillus infection has beneficial effects in experimental models of multiple sclerosis 4 |
|
WQ- SA D DL
|
YP_240040.1 ORF052 [Staphylococcus phage 47] |
Staphylococcal antigens (CSF) have been reported in MS pathients 5 |
|
F PKIFFR |
AAA48318.1| rifampicin resistance locus ORF [Vaccinia virus] |
Viral antibodies have been found in MS CSF and vaccinia infection in monkeys causes demyelination 6, 7 |
|
TTKFC D
|
AAG27040.1| major capsid protein L1 [Human papillomavirus] |
Seropositivity has been reported in MS patiens and HPV multiple vaccination has been reported to causes demyelination 8, 9 |
|
FVT PK
|
ADJ19560.1| gp34 proximal tail fiber subunit [Acinetobacter phage 133] |
Acinetobacter antiboides have been observed in MS patients 10 |
|
Myelin associated glycoprotein MAG AAB58805 |
A E D-GVYA |
YP_164320 Pseudomonas phage |
Peseudomonas antibodies cross reacting with myelun proteimns have been observed in MS patients 10, 11 |
KYYFR G |
YP_003406894 Marseille virus |
A novel giant virus infecting amoeba |
|
C P+LR P-L S- L |
ABV71654.Human herpesvirus 5 (Cytomegalovirus) |
Implicated: Seropositivity predicts a better outcome in Multiple Sclerosis (Beneficial virus ?) 12 |
|
GKYYF-R- D |
AAR31274 Human herpesvirus 5 (Cytomegalovirus) |
||
MOG NP_996535.2| Myelin oligodendrocyte protein |
S P KNAT
|
YP_001129462.1 YP_001129462.1 BLLF1 [Human herpesvirus 4 type 2] |
Epstein-Barr |
G E G-V--------F S D--------R D-H Y+ E E-AM E
|
ABM21503.1| polyprotein [Human coxsackievirus A11] CAJ01901.1| polyprotein [Human poliovirus 2] |
Coxsackie virus seropositivity has been associated with relapse in multiple sclerosis 13 |
|
P2 NP_002668.1 myelin P2 protein |
GLATR |
AAY41103.1| unknown [Human herpesvirus 4] |
Epstein-Barr |
SIVTL+
|
YP_401690.1| BGRF1/BDRF1 [Human herpesvirus 4]
|
Epstein-Barr |
|
MAT GLY
|
YP_024485.1 YP_024485.1 hypothetical protein KgORF55 [Staphylococcus phage K] |
||
LM AA SVL G |
NP_640308.1 [Vibrio phage VpV262] |
||
Q A GVLLI LL |
AAF70827.1| polyprotein [St. Louis encephalitis virus] |
||
+TI R E+ SK GLW |
ACC61905.1| polymerase PA [Influenza A virus (A/environment/New York/30720-3/2005(H7N2))] |
Influenza has been associated with MS onset 14 |
|
OSP NP_005593.2 claudin-11 isoform 1 |
L PAIL |
ACL99813.1| BDRF1 [Human herpesvirus 4] |
Epstein-Barr |
MAT GLY |
YP_024485.1hypothetical protein KgORF55 [Staphylococcus phage K] |
||
LM AA SVL G |
NP_640308.1 NP_640308.1 hypothetical protein [Vibrio phage VpV262] |
? |
|
PLP Proteolipid protein NP_001122306.1| gi|192449447|ref|NP_001122306.1|
myelin proteolipid protein |
AH SL E
|
AAY41097.1| unknown [Human herpesvirus 4]
|
Epstein-Barr |
KNYQ DY |
YP_002241961.1 YP_002241961.1 gp68 [Mycobacterium phage Gumball] |
Mycobacteria have been isolated from MS CSF 15 |
|
SLLT+MIA
|
YP_001686983.1 YP_001686983.1 thymidylate synthase-like protein [Glossina pallidipes salivary
gland hypertrophy virus]
|
This is a virus infecting the common fly
|
|
MOBP NP_891980.1 myelin-associated oligodendrocyte basic protein |
SQK PAK E |
ACZ55493.1| putative DNA polymerase [Staphylococcus phage SA1] |
|
RKIR PT |
NP_690897.1 NP_690897.1 VP7 [ |
||
DWIC |
YP_001129476.1 YP_001129476.1 BBRF1 [Human herpesvirus 4 type 2] |
||
SQK PAK E |
YP_001469181.1integrase [Streptococcus phage P9] |
Streptococcal infection has been linked to multiple sclerosis 16 |
|
LN S-K EIV D |
YP_239681.1 ORF013 [Staphylococcus phage 53] |
Table 2 Viral vatches identified for other multiple sclerosis autoantigens
HSP27= SOD 1 NP_000445.1 superoxide dismutase [Cu-Zn] |
KVWGSI |
YP_358771.1 YP_358771.1 putative tape measure protein [Lactobacillus phage Lc-Nu |
Lactobacillus infection has beneficial effects in experimental models of multiple sclerosis 4but milk consumption has also been linked to multiple sclerosis 17 |
EFGDNT |
YP_002003315.1 YP_002003315.1 gp1 [Yersinia phage Yepe2] |
? |
|
HGFHVH |
YP_142605.1|Lon domain protease [Acanthamoeba polyphaga mimivirus]
|
?
|
|
HSP32= HMOX1 NP_002124.1 heme oxygenase 1 |
FDQA-GLP-L AnD PVTFES |
YP_142796.1 YP_142796.1 hypothetical protein MIMI_L442 [Acanthamoeba polyphaga mimivirus]
|
?
|
YP_224275.1 YP_224275.1 hypothetical protein LPPPVgp44 [Listonella phage phiHSIC]
|
?
|
||
ALSRQLS
|
AAO59515.1| polymerase [Lassa virus]
|
?
|
|
HSP40 NP_006136.1 dnaJ homolog subfamily B member 1 |
VFKDVIR
|
CAJ28422.1| hypothetical protein [Phage PY100]
|
?
|
TVNV-TL+GR |
AAS89767.1| surface spike glycoprotein [Human group 1 coronavirus associated with pneumonia] |
Coronavirus seropositivity has been recorded in some multiple sclerosis patients 18 |
|
EGLKGS |
YP_002925110.1 YP_002925110.1 putative antireceptor protein [Streptococcus phage 5093] |
||
SGGSG |
AAY41102.1| unknown [Human herpesvirus 4] |
Epstein-Barr |
|
HSP47 NP_001226.2 serpin H1 precursor |
DFVRSSK |
YP_214345.1 YP_214345.1 hypothetical protein PSSM2_113 [Prochlorococcus phage P-SSM2] |
? |
EKEKL And GELLR
|
YP_001129449.1 YP_001129449.1 BPLF1 [Human herpesvirus 4 type 2 |
Epstein-Barr |
|
HSP60 NP_002147.2 60 kDa heat shock protein, mitochondria = HSPD1 |
NLEDVQ |
AAY41124.1| unknown [Human herpesvirus 4] |
|
VEVN-KKD |
ADD80843.1| gp057 [Rhodococcus phage ReqiDocB7] |
? |
|
E--DVTTS |
ABO69378.1| polyprotein [Human rhinovirus 3] |
Rhinoviruses have been associated with relapse 19 |
|
IEGMK |
CAR95428.1| hypothetical protein [Streptococcus phage phi-m46.1] |
Streptococcal infection has been linked to multiple sclerosis 16 |
|
VEIRR |
ABR27363.1| polyprotein [Hepatitis C virus] |
Hepc infection can sometimes mimic MS 20 |
|
HSP70 NP_002145.3 heat shock 70 kDa protein 4 |
IGAAA |
AAA02785.2| BLRF3 [Human herpesvirus 4] |
Epstein-Barr |
ESEERP |
AAB59844.1| latent membrane protein 2 [Human herpesvirus 4] |
Epstein-Barr |
|
EYEKFVS |
AAW30715.2| polyprotein [Human coxsackievirus A16] and A7 and A14 |
Coxsackie virus seropositivity has been associated with relapse in multiple sclerosis 13 |
|
DQFFG |
EBNA3 Epstein-Barr virus |
Epstein-Barr 21 |
|
HSPSRL |
D2XR26 Bacillus phage |
? |
|
R-PSFLR |
9PARAQ84747 Human parainfluenza virus 1 |
Epstein-Barr 22 |
|
IENEGKM
And
VAVARA |
ADE28700.1| polyprotein [Norovirus Hu/GII/8610/Saga/2008/JPN] |
? |
|
LTMDPV |
BAF46192.1| capsid protein [Norovirus oyster/GI/Yamaguchi/H17-81B/05/JP] |
? |
|
MEEER
|
AAM95184.2| polyprotein [Norwalk-like virus] |
? |
|
SLSSDGV |
C9WSX19 Norovirus dog |
Dog ownership has been linked to multiple sclerosis23, 24 |
|
HSP71 NP_006588.1 heat shock cognate 71 kDa protein isoform 1 |
R DKV S and AVVQ S |
AAY41102.1| unknown [Human herpesvirus 4] |
Epstein-Barr |
GRL K E-D-ER |
AAB66985.1| hepatitis delta antigen [Hepatitis delta virus] |
? |
|
EL EKVCN |
YP_803051.1 YP_803051.1 hypothetical protein RB32ORF109c [Enterobacteria phage RB32 |
Gut bacteria also display antigens that mimic MS autoantigens 25 |
|
SIN P D EA |
NP_899398.1 hypothetical protein KVP40.0152 [Vibrio phage KVP40] |
? |
|
R RL D PR P |
ABB89278.1 ABB89278.1 BXRF1 [Human herpesvirus 4] |
Epstein-Barr |
|
M P E ETQT |
AAB53568.1| non-structural 5a protein [Hepatitis C virus] |
Hepc infection can sometimes mimic MS 20 |
|
RT DT G E P |
ABO60719.1 , bacteriophage-acquired protein [Burkholderia phage phiE202] |
? |
|
Beta amyloid |
MV G GVV
|
ABC58497.1| non-structural protein 4b [Hepatitis C virus] |
Hepc infection can sometimes mimic MS 20 |
E DV G SN
|
ADH04357.1| envelope glycoprotein [Human immunodeficiency virus 2]
|
HIV infection has been associated with MS 20 |
|
SNK GAI
|
ABJ16576.1| hemagglutinin [Influenza A virus (A/mallard/Ohio/64/1989(H6N8))]
|
Influenza has been associated with MS onset 14 |
|
GAII GL
|
ZP_04863779.1| crispr-associated protein Cas5, hmari subtype [Clostridium phage
D-1873]
|
?
|
|
Viruses Aligning with VGGVV in Beta-amyloid |
|||
Dengue virus 1 ACQ44424 Polyprotein; Hepatitis C :ACY65348 envelope protein 2 : Human adenovirus 8: BAH18864 17.7kDa protein Human herpesvirus 1:P08665Envelope glycoprotein B: Human herpesvirus 2:NP_044471Glycoprotein B Human herpesvirus 6:AAA43846:Envelope glycoprotein B Human herpesvirus 6B;BAA78260Envelope glycoprotein B Human immunodeficiency virus:ACQ42512vif Protein Lactate dehydrogenase-elevating virus; YP_001008394:Polyprotein 1ab Polyomavirus HPyv6 and 7: ADE45477:VP Yellow fever virus:NP_776003 Polyprotein : NS2A: |
Beta-amyloid vaccination in Alzheimer’s disease patients caused Meningoencephalitis 26 |
||
Phages infecting human bacteria |
|||
Aeromonas phage YP_238875 WAC Enterobacteria phage NP_037676 tail length tape measure protein Escherichia phageYP_002003548 hypothetical protein Mycobacterium Phage ACU41726 GP233 Prochlorococcus phageACY76180 Hypothetical protein Pseudomonas phage Tail fiber assembly protein Serratia phage KSP20 TAILC_BPSK2 Streptomyces phage NP_958289 ORF9 Vibrio phage AAQ96489 Hypothetical protein |
Ff
Table 3 Other Epstein Barr homologues of relevance to multiple sclerosis
Table 4 : Other viruses and phages matching EIF2B5 vatches.
EIF2B5 NP_003898.2| gi|83267879|ref|NP_003898.2| Description translation initiation factor eIF-2B subunit epsilon |
Viral protein |
Notes |
N+EEEEEL
|
YP_001468597 gp27 [Listeria phage A511] |
Listeria can provoke demyelination in chickens and Man 48, 49 |
ILSWFS+R
|
BAA33482 unnamed protein product [Vibrio phage fs2] |
? |
DFVRG---LVNE
|
|NP_813766 hypothetical protein gh-1p20 [Pseudomonas phage gh-1] |
Pseudomonas infections and bacterial mimicry of MS autoantigens have been reported 10, 11, 50 |
EHEALG
|
ABS84900 VP13/14 [Human herpesvirus 2] |
HSV-2 infection has been implicated in multiple sclerosis 22 |
VLLPLA
|
AAX13234 unknown [Lactococcus lactis bacteriophage Tphi712] |
Lactobacillus infection has beneficial effects in experimental models of multiple sclerosis 4 |
EYGAR+S+
|
NP_695059 [Lactococcus phage r1t] |
|
KGYLWK
|
YP_001469129.1gp130 [Lactococcus phage KSY1] |
|
ANVAL
|
ABD95922 matrix protein [Human metapneumovirus] |
? |
TDSTTQS
|
AAX84049 attachment glycoprotein [Human metapneumovirus] |
? |
QRFI+WLK
|
AAK59932 polyprotein [Human coxsackievirus B1] |
Coxsackie virus seropositivity has been associated with relapse in multiple sclerosis 13 |
LRRKLE
|
BAD12610 capsid protein VP1 [Human coxsackievirus B5] |
|
A PPGV-V--RAN |
NP_613027 Gene info linked to NP_613027.1 hypothetical protein Stx2Ip149 [Stx2 converting phage I] |
? |
PNITLP
|
P36849.2|HEX_ADE03 RecName: Full=Hexon protein; AltName: Full=Late protein 2 emb|CAA54051 hexon protein [Human adenovirus type 3] |
Adenovirus infection has been associated with relapse in multiple sclerosis 3 |
DE+DGE--DD
|
CAI11372.1| hexon capsid protein [Human adenovirus type 50] |
|
LC--AEVKER |
ACK57100 truncated L1 capsid protein [Human papillomavirus] |
Seropositivity has been reported in MS patiens and HPV multiple vaccination has been reported to causes demyelination 8, 9 |
TLQRGK |
CAD30240 gp30.3' protein [Bacteriophage CAJ76662 gp30.3' protein [Enterobacteria phage RB14] |
Gut bacteria also display antigens that minic MS autoantigens 25 |
HLEAL
|
ABU83679 polymerase [Hepatitis B virus] |
Hepatitis B infection may protect against MS, while vaccination has been associated with the development of multiple sclerosis 51, 52 |
YRGP+VS
|
ABQ08535 proteinase/helicase [Hepatitis C virus] |
Hepc infection can sometimes mimic MS 20 |
SGGG--ARGA
|
AAF19874 AF206362_1 polyprotein [Hepatitis C virus] |
|
LRRKLE |
ABF82333 capsid protein [Human coxsackievirus B5] |
Coxsackie virus seropositivity has been associated with relapse in multiple sclerosis 13 |
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