CFTR Blasts

BLAST results showing the consensus sequences along the length of the native CFTR protein for S.Aureus, P.Aeruginosa, S.Maltophilia or autoantigen matches: The B cell and T cell epitope immunogenicity index is also provided. Values above the server-set thresholds (0.35 for B cell and 0.5 for T cell ) are shown in red. The topology of the CFTR protein is shown in the final column (EXT = extracellular: IN = intracellular; TM = transmembrane): Extracellular regions are highlighted in red: Autoantigen overlaps are highlighted in blue. The whole protein is not processed and BLAST searches were focussed on auto antigen overlaps in antigenic extracellular regions.

Jens Erik Pontoppidan Larsen, Ole Lund and Morten Nielsen. Improved method for predicting linear B-cell epitopes. Immunome Res. 2006; 2: 2.

M. Nielsen, C. Lundegaard, O. Lund, and C. Kesmir. 2005. The role of the proteasome in generating cytotoxic T cell epitopes: Insights obtained from improved predictions of proteasomal cleavage. Immunogenetics. 57:33-41.

BLAST results of the F508del and 19 other mutants are shown at the bottom of this page

N	Autoantigen coverage in blue	Pathogen or autoantigen alignment	B cell epitopes in red	T cell epitopes in red	Topology (Extracellular= Red)
1	M	S.Malt MQR PL� AS	0.64	0.84	IN
2	Q	Q	0.36	0.10	IN
3	R	(mucin) RSP EK S P.Aer R PLEK S and RSPLE� KA� and RSPL KA S.Malt RSPL+K S.Aur R P LEKA	0.61	0.59	IN
4	S	S	0.65	0.03	IN
5	P	S.Aur and S.Malt PLEKA	0.60	0.02	IN
6	L	L	0.83	0.40	IN
7	E	S.Malt LEKAS	0.63	0.03	IN
8	K	K	0.36	0.30	IN
9	A	A	0.19	0.09	IN
10	S	S	0.07	0.04	IN
11	V	V	-0.17	0.27	IN
12	V	V	-0.75	0.94	IN
13	S	S	-1.19	0.06	IN
14	K	K	-1.17	0.84	IN
15	L	L	-1.48	0.96	IN
16	F	F	-1.14	0.82	IN
17	F	F	-0.90	0.15	IN
18	S	S	-0.89	0.03	IN
19	W	W	-1.07	0.93	IN
20	T	T	-0.94	0.03	IN
21	R	R	-0.60	0.58	IN
22	P	(myelo) PILR� P.Aer and�� S.Aur and S.Malt PILRK S.Malt P+LR GYRQ	-0.20	0.10	IN
23	I	I	-0.15	0.49	IN
24	L	(S.Malt) LRK Y QR	0.07	0.66	IN
25	R	R	-0.06	0.55	IN
26	K	(P.Aer)KGYR	-0.16	0.95	IN
27	G	S.Malt� GYRQRL	-0.15	0.07	IN
28	Y	(P.Aer) YRQRL	-0.25	0.92	IN
29	R	(P.Aer) RQRLE-SD	0.03	0.84	IN
30	Q	(S.Malt) QRL LSD	-0.21	0.08	IN
31	R	(P.Aer) RLEL	-0.19	0.57	IN
32	L	L	-0.18	0.98	IN
33	E	E	-0.35	0.02	IN
34	L	L	-0.57	0.71	IN
35	S	S	-0.49	0.04	IN
36	D	(P.Aer) DIYQI	-0.64	0.03	IN
37	I	I	-0.26	0.10	IN
38	Y	Y	-0.13	0.97	IN
39	Q	Q	0.18	0.05	IN
40	I	I	0.33	0.70	IN
41	P	P	0.40	0.17	IN
42	S	(P.Aer) SVDSA-N	0.70	0.05	IN
43	V	V	1.04	0.82	IN
44	D	D	1.08	0.23	IN
45	S	S	1.02	0.10	IN
46	A	A	1.06	0.13	IN
47	D	D	0.95	0.07	IN
48	N	(P.Aer) +NLSE	1.01	0.10	IN
49	L	(myelo) LSEK +P.Aer and� S.Aur and S.Malt LSEKL	0.54	0.68	IN
50	S	S	0.50	0.06	IN
51	E	S.Malt EKLERE	0.43	0.04	IN
52	K	K	0.44	0.85	IN
53	L	L	0.12	0.97	IN
54	E	E	0.56	0.02	IN
55	R	R	0.49	0.26	IN
56	E	E	0.56	0.03	IN
57	W	W	0.22	0.53	IN
58	D	D	0.45	0.02	IN
59	R	(P.Aer) RELAS	0.43	0.75	IN
60	E	E	0.53	0.03	IN
61	L	L	0.56	0.95	IN
62	A	A	1.00	0.16	IN
63	S	S	0.84	0.18	IN
64	K	K	0.89	0.60	IN
65	K	K	0.56	0.31	IN
66	N	N	0.53	0.03	IN
67	P	P	0.51	0.02	IN
68	K	K	0.31	0.28	IN
69	L	L	-0.11	0.80	IN
70	I	I	-0.43	0.19	IN
71	N	(P.Aer) NALR	-0.83	0.03	IN
72	A	A	-1.11	0.15	IN
73	L	L	-1.61	0.82	IN
74	R	(prot) RRC F�� F F� P.Aer� RRCFF S.Aur RCFF S.Malt RR FF	-1.81	0.69	IN
75	R	R	-1.92	0.11	IN
76	C	C	-2.00	0.03	IN
77	F	F	-2.28	0.05	IN
78	F	(P.Aer) FWRF+ Y	-2.29	0.06	IN
79	W	(P.Aer) WRFM (rheum) WRF+F	-2.56	0.11	IN
80	R	R	-2.62	0.05	IN
81	F	F	-2.46	0.89	IN
82	M	(P.Aer) MFYG	-2.40	0.09	IN
83	F	(BPI) F+G F� L EV K	-2.34	0.11	IN
84	Y	Y	-2.43	0.85	TM
85	G	G	-2.54	0.06	TM
86	I	I	-2.46	0.24	TM
87	F	S.Malt FLYLG�	-2.12	0.34	TM
88	L	(P.Aer) LYLG+VT	-1.65	0.63	TM
89	Y	Y	-1.50	0.96	TM
90	L	(myelo)LGEV�� L L�	-1.35	0.97	TM
91	G	G	-0.97	0.13	TM
92	E	E	-0.63	0.02	TM
93	V	(BPI) VT AV P	-0.17	0.86	TM
94	T	T	0.18	0.03	TM
95	K	K	0.46	0.97	TM
96	A	A	0.14	0.80	TM
97	V	V	-0.24	0.92	TM
98	Q	(P.Aer) QPLL-GRI	-0.57	0.03	TM
99	P	P	-0.72	0.04	TM
100	L	L	-0.84	0.94	TM
101	L	S.Malt LLGR+I S	-1.09	0.78	TM
102	L	L	-1.36	0.20	TM
103	G	G	-1.58	0.05	TM
104	R	R	-1.46	0.21	TM
105	I	I	-1.09	0.61	TM
106	I	I	-0.49	0.54	TM
107	A	S.Malt A YDPDN E�� ERS+ and A YDPD S.Aur ASYD and A YDPD S.Malt ASYDP�� DN and� AS DPDN P.Aer A YDPD and ASYD D and ASYD P�� EE	0.07	0.72	EXT
108	S	P.Aer SYDPD�� N E R S.Aur SY DP++KE �and SY D DNKE� and SYDP�� EE S.Malt� SYDPD	0.49	0.09	EXT
109	Y	(prot) YD +NK (P.Aer) YDPD and� YD�� KEER S.Aur� Y PD NKEE and YD +NKE+ and� YDPD� EE and� YD +NKE+ and YDP�� DNK	0.87	0.98	EXT
110	D	S.Aureus DPDNKE and DP++ EER and +PD KEE and D KEER� and DPD NKE� and D DNKE S.Malt DPDN� ER	1.31	0.02	EXT
111	P	(myelo) PD� +ERS S.Malt� P+ KEER and PDNK+ R P.Aer PDNKE� and P+NK ER S.Aur PD KEER	1.77	0.26	EXT
112	D	S.Aur DNKE+R and DNKEE P.Aer D KEER	2.06	0.03	EXT
113	N	S.Aur and S.Malt NKEER P.Aer NK+ER	2.02	0.03	EXT
114	K	K	2.03	0.27	EXT
115	E	E	1.42	0.08	EXT
116	E	E	1.14	0.03	EXT
117	R	R	0.41	0.38	EXT
118	S	S	-0.05	0.04	EXT
119	I	(S.Aur) IAI LG G S.Malt IAI LGIG	-0.61	0.11	EXT
120	A	(GAD65) A� LGIG	-0.77	0.03	EXT
121	I	I	-1.24	0.32	TM
122	Y	Y	-1.31	0.69	TM
123	L	(GAD65) LGIG (S.Malt) LGIGL	-1.83	0.76	TM
124	G	G	-1.76	0.06	TM
125	I	I	-2.19	0.40	TM
126	G	G	-2.35	0.03	TM
127	L	S.Malt LCLLF	-2.68	0.17	TM
128	C	C	-2.71	0.03	TM
129	L	L	-2.98	0.76	TM
130	L	(myelo) L�� TLLL	-2.78	0.81	TM
131	F	F	-2.85	0.12	TM
132	I	S.Malt IVRTLL	-2.82	0.15	TM
133	V	V	-3.02	0.40	TM
134	R	R	-2.81	0.57	TM
135	T	T	-2.30	0.07	TM
136	L	(P.Aer) LLLH-A	-1.82	0.91	TM
137	L	L	-1.43	0.97	TM
138	L	L	-1.33	0.79	TM
139	H	H	-1.58	0.03	TM
140	P	P	-1.56	0.05	TM
141	A	A	-1.48	0.38	TM
142	I	I	-1.15	0.39	TM
143	F	F	-0.93	0.89	TM
144	G	G	-1.22	0.03	IN
145	L	L	-1.19	0.96	IN
146	H	H	-1.39	0.15	IN
147	H	(P.Aer)� HIGM	-1.21	0.18	IN
148	I	I	-1.14	0.58	IN
149	G	G	-1.13	0.05	IN
150	M	M	-1.16	0.35	IN
151	Q	Q	-1.23	0.03	IN
152	M	M	-1.37	0.96	IN
153	R	R	-1.43	0.04	IN
154	I	I	-1.55	0.23	IN
155	A	A	-1.72	0.03	IN
156	M	(mucin) MF L IYK	-2.06	0.05	IN
157	F	F	-1.98	0.39	IN
158	S	S	-1.90	0.02	IN
159	L	L	-1.52	0.57	IN
160	I	I	-1.31	0.32	IN
161	Y	Y	-1.38	0.95	IN
162	K	K	-1.02	0.69	IN
163	K	(P.Aer)� KT KLSS	-1.23	0.97	IN
164	T	T	-0.77	0.04	IN
165	L	(rheum) LKLSS S.Aur amd P.Aer LKLSS S.Malt LKLS	-0.44	0.92	IN
166	K	(P.Aer)� KLSS (rheum) KLSS	-0.28	0.67	IN
167	L	L	-0.48	0.97	IN
168	S	S	-0.80	0.09	IN
169	S	S	-0.79	0.03	IN
170	R	R	-0.44	0.65	IN
171	V	V	-0.69	0.44	IN
172	L	L	-0.33	0.90	IN
173	D	D	-0.62	0.03	IN
174	K	K	-0.61	0.55	IN
175	I	I	-0.59	0.39	IN
176	S	(P.Aer)� SIG LVS	-0.67	0.02	IN
177	I	I	-0.60	0.46	IN
178	G	G	-0.77	0.22	IN
179	Q	Q	-1.14	0.32	IN
180	L	(P.Aer) +LVSLLS	-1.19	0.61	IN
181	V	VSLL	-1.22	0.42	IN
182	S	S.Malt SLLSN+	-0.95	0.08	IN
183	L	L	-0.88	0.83	IN
184	L	(P.Aer) LSNNL	-1.12	0.84	IN
185	S	(rheum) SNNL	-0.83	0.03	IN
186	N	N	-0.57	0.04	IN
187	N	N	-0.67	0.03	IN
188	L	L	-0.11	0.95	IN
189	N	N	0.31	0.04	IN
190	K	K	0.41	0.76	IN
191	F	(P.Aer) FDE-LA [FDEG]	0.09	0.96	IN
192	D	(P.Aer) DEGL	-0.09	0.02	IN
193	E	(P.Aer) +GLALAH	-0.19	0.03	IN
194	G	G	-0.35	0.02	IN
195	L	(P.Aer) LALAHF	-0.52	0.81	IN
196	A	A	-0.64	0.04	TM
197	L	L	-1.13	0.79	TM
198	A	A	-1.59	0.72	TM
199	H	H	-1.90	0.03	TM
200	F	F	-1.64	0.27	TM
201	V	V	-1.55	0.13	TM
202	W	(myelo) W+ PLQV S.Malt� WIAPL +AL	-1.40	0.92	TM
203	I	S.Malt IAPLQVA	-1.16	0.14	TM
204	A	A	-1.25	0.06	TM
205	P	(GAD65) PLQ�� L� L+ E� L+Q	-1.07	0.03	TM
206	L	(P.Aer) L+VALL	-1.23	0.97	TM
207	Q	S.Malt� QVALLM� I	-1.24	0.04	TM
208	V	(P.Aer) V LLMG [VALL](S.Malt) VALLM L	-1.38	0.86	TM
209	A	(P.Aer) A-LMGL	-1.46	0.05	TM
210	L	L	-1.84	0.73	TM
211	L	(P.Aer) LMGLI	-1.88	0.85	TM
212	M	(S.Malt) MG I ELLQ	-2.38	0.82	TM
213	G	G	-2.16	0.05	TM
214	L	L	-2.34	0.23	TM
215	I	I	-2.21	0.08	TM
216	W	S.Malt WELLQAS S.Aur W+LLQ P.Aer WELL+	-1.84	0.56	EXT
217	E	S.Malt� ELLQA	-1.53	0.02	EXT
218	L	L	-1.33	0.96	EXT
219	L	L	-1.08	0.91	TM
220	Q	(P.Aer) QAS-AFCG+G [QASAF]	-1.12	0.05	TM
221	A	A	-0.89	0.64	TM
222	S	S	-0.88	0.23	TM
223	A	A	-0.90	0.25	TM
224	F	(prot) FCG G LI	-0.60	0.45	TM
225	C	C	-1.02	0.03	TM
226	G	(myelo) LG L V�� FQ�� GR ++ + +�� R�� I�� L�� SEM E (P.Aer) GLGFLIV [GLGFL VL ]	-1.40	0.03	TM
227	L	L	-1.96	0.26	TM
228	G	G	-2.17	0.03	TM
229	F	(myelo) +L V AL	-2.31	0.08	TM
230	L	(Adren)� LIVLA (mucin) +LI LA	-2.38	0.24	TM
231	I	I	-2.74	0.17	TM
232	V	V	-2.71	0.22	TM
233	L	(P.Aer) LALF+A	-2.66	0.89	TM
234	A	A	-2.31	0.68	TM
235	L	L	-1.80	0.88	TM
236	F	F	-1.55	0.93	TM
237	Q	Q	-1.19	0.03	TM
238	A	A	-0.85	0.20	TM
239	G	G	-0.88	0.03	TM
240	L	S.Malt LGRMM	-0.79	0.64	TM
241	G	G	-0.77	0.02	TM
242	R	R	-0.86	0.16	IN
243	M	M	-0.93	0.50	IN
244	M	M	-0.98	0.11	IN
245	M	M	-0.59	0.77	IN
246	K	(P.Aer) KYRD+	-0.51	0.90	IN
247	Y	Y	-0.30	0.91	IN
248	R	R	-0.01	0.03	IN
249	D	(myelo) +Q A�� I ERL	0.36	0.03	IN
250	Q	(P.Aer) QRAG	0.75	0.03	IN
251	R	R	0.65	0.09	IN
252	A	A	0.85	0.08	IN
253	G	(hspd1)� GK+ E� VI T +� M�� IE� IQ (P.Aer) GKI ERLV	0.82	0.04	IN
254	K	K	0.63	0.28	IN
255	I	I	0.13	0.82	IN
256	S	S	-0.26	0.02	IN
257	E	(P.Aer) ERLV	-0.62	0.03	IN
258	R	R	-0.65	0.43	IN
259	L	(TNF) LV+ SE	-0.70	0.84	IN
260	V	V	-0.47	0.11	IN
261	I	I	-0.71	0.14	IN
262	T	T	-1.00	0.04	IN
263	S	S	-0.97	0.04	IN
264	E	E	-0.54	0.06	IN
265	M	M	-0.47	0.95	IN
266	I	S.Malt +IENIQ	-0.11	0.46	IN
267	E	E	-0.10	0.02	IN
268	N	N	-0.25	0.02	IN
269	I	I	-0.27	0.14	IN
270	Q	Q	-0.23	0.02	IN
271	S	S	-0.14	0.03	IN
272	V	V	-0.21	0.94	IN
273	K	K	-0.54	0.94	IN
274	A	A	-0.25	0.80	IN
275	Y	GAD65 Y WE� +� + + E L�� QT LK�� K�� RYFN	-0.17	0.51	IN
276	C	C	-0.20	0.02	IN
277	W	W	-0.21	0.90	IN
278	E	E	-0.21	0.02	IN
279	E	E	-0.14	0.03	IN
280	A	A	-0.17	0.04	IN
281	M	M	-0.36	0.19	IN
282	E	Calgran EK IE�� +	-0.09	0.02	IN
283	K	K	-0.18	0.53	IN
284	M	M	-0.56	0.21	IN
285	I	Adren ++NL Q E	-0.55	0.06	IN
286	E	E	-0.37	0.02	IN
287	N	N	-0.37	0.03	IN
288	L	(myelo) LR�� LKL RK	-0.19	0.68	IN
289	R	R	-0.32	0.45	IN
290	Q	Q	-0.06	0.03	IN
291	T	(P.Aer) TELKL	-0.40	0.09	IN
292	E	E	-0.40	0.03	IN
293	L	(myelo) LKL RK	-0.13	0.97	IN
294	K	K	-0.05	0.35	IN
295	L	L	-0.13	0.83	IN
296	T	(prot) TR A YV	-0.24	0.03	IN
297	R	R	-0.49	0.35	IN
298	K	K	-0.37	0.46	IN
299	A	(P.Aer) AAYV-Y	-0.46	0.09	IN
300	A	Adren A� RYF�� F	-0.29	0.06	IN
301	Y	Y	-0.60	0.57	IN
302	V	V	-0.52	0.72	IN
303	R	(P.Aer) R+FNSS (GAD65) RYFN	-0.52	0.15	IN
304	Y	Y	-0.39	0.96	TM
305	F	(mucin) FNSS	-0.42	0.23	TM
306	N	Adren N SAF	-0.65	0.02	TM
307	S	S	-0.81	0.03	TM
308	S	S	-1.05	0.17	TM
309	A	A	-0.87	0.29	TM
310	F	F	-0.60	0.96	TM
311	F	S.Malt FFSGF	-1.00	0.53	TM
312	F	F	-1.47	0.08	TM
313	S	S	-1.92	0.02	TM
314	G	(P.Aer) GFFVVFL	-2.20	0.05	TM
315	F	F	-2.24	0.45	TM
316	F	F	-2.29	0.44	TM
317	V	V	-2.06	0.29	TM
318	V	V	-2.21	0.95	TM
319	F	F	-2.43	0.92	TM
320	L	(mucin) LSV P	-2.11	0.61	TM
321	S	S	-1.85	0.04	TM
322	V	(P.Aer)� V-PYAL	-1.54	0.85	TM
323	L	L	-1.54	0.83	TM
324	P	P	-1.41	0.03	TM
325	Y	Y	-1.05	0.93	TM
326	A	(P.Aer) A-IKGI [ALIK I]	-0.99	0.11	TM
327	L	L	-1.15	0.44	EXT
328	I	I	-1.26	0.25	EXT
329	K	K	-1.66	0.46	EXT
330	G	G	-1.68	0.03	EXT
331	I	I	-1.74	0.62	EXT
332	I	I	-1.69	0.17	EXT
333	L	L	-1.72	0.32	EXT
334	R	R	-1.73	0.62	EXT
335	K	(P.Aer)� KIFTTIS	-1.68	0.92	EXT
336	I	I	-1.61	0.10	EXT
337	F	F	-1.33	0.06	EXT
338	T	T	-1.36	0.02	EXT
339	T	T	-1.45	0.06	EXT
340	I	I	-1.83	0.96	EXT
341	S	S	-1.89	0.07	EXT
342	F	F	-2.04	0.92	EXT
343	C	(S.Aur) CIVL	-2.09	0.03	EXT
344	I	I	-2.38	0.50	EXT
345	V	V	-2.22	0.13	EXT
346	L	L	-2.36	0.75	EXT
347	R	R	-1.86	0.47	EXT
348	M	M	-1.67	0.89	EXT
349	A	A	-1.05	0.08	EXT
350	V	V	-0.87	0.07	EXT
351	T	(prot) TR FP S.Malt TRQFP S.Aurand P.Aer� TR+FP	-0.34	0.03	EXT
352	R	P.Aer RQFP	-0.44	0.39	EXT
353	Q	Q	-0.09	0.03	EXT
354	F	F	-0.11	0.42	EXT
355	P	P	0.18	0.02	EXT
356	W	W	0.17	0.72	EXT
357	A	(P.Aer) AVQTW	0.00	0.05	EXT
358	V	V	-0.18	0.93	EXT
359	Q	Q	0.12	0.12	EXT
360	T	T	0.14	0.38	EXT
361	W	W	0.15	0.97	EXT
362	Y	Y	0.11	0.97	EXT
363	D	(HSPD1) DSL�� N� Q�� TL (TNF)� D L A IN�� D+L	0.16	0.04	EXT
364	S	S	-0.11	0.02	EXT
365	L	L	-0.13	0.38	EXT
366	G	(Mucin) G IN ++D�� F Q�� YKT E�� YNLT� +V	0.06	0.05	EXT
367	A	A	-0.09	0.07	EXT
368	I	I	-0.19	0.27	EXT
369	N	N	-0.23	0.03	EXT
370	K	K	-0.32	0.28	EXT
371	I	I	-0.65	0.88	EXT
372	Q	Calgran� Q+FL K E K�� N�� E +ME+	-0.57	0.10	EXT
373	D	D	-0.32	0.03	EXT
374	F	(GAD65) FLQ�� L+Y	-0.22	0.77	EXT
375	L	L	-0.07	0.38	EXT
376	Q	Q	0.08	0.03	EXT
377	K	K	0.08	0.77	EXT
378	Q	Q	0.06	0.29	EXT
379	E	E	0.08	0.03	EXT
380	Y	(mucin) YKT E�� YNLT� +V	0.47	0.80	EXT
381	K	K	0.28	0.42	EXT
382	T	T	0.27	0.04	EXT
383	L	L	-0.13	0.88	EXT
384	E	E	-0.21	0.03	EXT
385	Y	(mucin)YNLT� +V P.Aer� YN LTTT�� +V M S.Aur Y LT T+VV S.Malt YN T� EVV	-0.10	0.97	EXT
386	N	P.Aer NL TTE� VV S.Aur NLTTTE S.Malt NLTTT and NLTT E++	-0.03	0.03	EXT
387	L	(hspd1) LTT EVV P.Aer� L TT+VV S.Aur LTTT+	0.04	0.71	EXT
388	T	P.Aer and S.Malt TTTEV S.Aur TT� VVM S.Malt +TTTEV	0.09	0.03	EXT
389	T	P.Aer and S.Aur and S.Malt TTEVV	-0.20	0.08	EXT
390	T	P.Aer TEVVM S.Aur TEV+M S.Malt TE� VV M	-0.23	0.08	EXT
391	E	P.Aer and S.Aur EVVM S.Malt EV+M	-0.27	0.04	EXT
392	V	V	0.06	0.82	EXT
393	V	V	-0.10	0.16	EXT
394	M	M	-0.16	0.70	EXT
395	E	E	-0.33	0.02	EXT
396	N	N	-0.66	0.08	EXT
397	V	V	-0.68	0.15	EXT
398	T	T	-0.33	0.06	EXT
399	A	A	0.03	0.20	EXT
400	F	F	0.15	0.84	EXT
401	W	W	-0.07	0.96	EXT
402	E	S.Malt EEG GE� +	0.10	0.02	EXT
403	E	(P.Aer) EGFGELF	0.10	0.03	EXT
404	G	G	-0.08	0.05	EXT
405	F	F	-0.13	0.10	EXT
406	G	G	0.14	0.03	EXT
407	E	(P.Aer)� EL FEKAKQ and ELFEKA and ELFEK and ELFE A and EL EKA� NN� and +LFEK K+N S.Aur ELFEK and EL E� AKQN N and +LFEK and� ELFE�� AK and ELFE�� K�� NN N and ELF�� E� KAKQ� and� +LFEK and E FEKA S.Malt ELFEK and +LFEK and ELF+ AK� and ELFE A Q N	0.06	0.03	EXT
408	L	S.Aur� LFEK� Q� N+N and LFE AK� N+ and LFEK K and LFEK K and L EKAK� N+ and LFEKA and� LFEKA Q abd LF�� KQNNN S.Malt� LF+KA� QN� and LFEK�� NN� and� LFEK� KQ and LFE KAK and LFE�� AKQ P.Aer LF� AKQN and� LFE AK and LF KAK+ and LFE� KQN and LFEK KQ	-0.05	0.94	EXT
409	F	S.Aur FEK KQNN N andand FEK� +NN� F+KAK++� and FEKA K +N+ N and FE�� NNNN P.Aer FEKAKQ and� FEKAK and FEK KQ and +EKAK++ and F+KA +N and +EKAK++ and +EKAKQ S.Malt FEKA QN and FEK KQ	-0.07	0.65	EXT
410	E	S.Aur� EKAKQN and EKAKQ +NN and EKAKQ +NN and�� E AKQN and EKAKQ +N and EKA QN�� NN� and E AKQN and EK AKQN and EK� KQNN and� EKAK+N S.Malt EKAK� N N and EKAKQ P.Aer E AKQN and EKAK� N+ and EKA QN	0.23	0.03	EXT
411	K	S.Aur KAK� QN NN and EK AKQN and KAKQ N and KAKQN and� K KQN NN P.Aer KAKQ N S.Malt KAKQN	0.33	0.80	EXT
412	A	S.Malt AKQNN S.Aur AKQN�� NN and AKQN N and A QNNN and AKQ� NN and AK+N NN and AK+NNN	0.48	0.15	EXT
413	K	S.Aur� KQNNN and KQNN+ and KQN NN and KQNN N and KQNN�� NN	0.89	0.16	EXT
414	Q	P.Aer and S.Aur +NNNN S.Aur QNNNN and QN+NN	1.32	0.05	EXT
415	N	N	1.36	0.07	EXT
416	N	(S.Aur)� N-NNR-T	1.40	0.02	EXT
417	N	N	1.47	0.03	EXT
418	N	N	1.53	0.03	EXT
419	R	R	1.61	0.90	EXT
420	K	K	1.66	0.90	EXT
421	T	T	1.78	0.16	EXT
422	S	S	1.86	0.03	EXT
423	N	N	1.78	0.03	EXT
424	G	(P.Aer) GDDS	1.34	0.03	EXT
425	D	D	0.87	0.02	EXT
426	D	D	0.40	0.03	EXT
427	S	S	0.19	0.02	EXT
428	L	(TNF) LF S FS L S.Malt LFFS+ and LFFS�� L S.Aur� +FFSNF P.Aer L FSNF and L+FS FS	0.02	0.88	EXT
429	F	S.Malt FF� FSL S.Aur FF NFS	-0.49	0.24	EXT
430	F	S.Malt F NFSL S.Aur FS FSL P.Aer FSNF L	-0.85	0.56	EXT
431	S	S.Malt S+FSL S.Aur SNFS and S+FSL P.Aer SNFSL	-1.43	0.07	EXT
432	N	P.Aer and S .Aur and S.Malt NFSL	-1.78	0.08	EXT
433	F	S.Malt FSLLG	-1.31	0.88	EXT
434	S	P.Aer SLL-TVPL (S.Malt) SLLG P	-0.83	0.03	EXT
435	L	L	-0.40	0.97	EXT
436	L	L	-0.47	0.95	EXT
437	G	G	-0.71	0.06	EXT
438	T	T	-0.45	0.02	EXT
439	P	(S.Aur) P+LKDIN� IE	-0.30	0.03	EXT
440	V	(P.Aer) VLKDI (S.Aur)VLKDIN and� VL DINF (S.Malt) VLKD+	-0.20	0.46	EXT
441	L	(S.Aur) LKD+ F + R	0.14	0.66	EXT
442	K	K	-0.34	0.93	EXT
443	D	(GAD65) DI+F�� IER GQ	-0.45	0.04	EXT
444	I	I	-0.81	0.63	EXT
445	N	N	-0.60	0.02	EXT
446	F	(P.Aer) F-IERG	-0.36	0.87	EXT
447	K	K	-0.24	0.56	EXT
448	I	S.Malt IERGQ	-0.33	0.98	EXT
449	E	(S.Malt) +ERGQL	-0.36	0.03	EXT
450	R	(P.Aer) RGQLL [ RGQ LAV]	-0.78	0.13	EXT
451	G	(myelo) GQLL S.Malt GQLLA	-0.58	0.09	EXT
452	Q	S.Malt QLLA� GS	-0.75	0.03	EXT
453	L	(P.Aer) LL VAGS (GAD65) LLAVA (S.Malt) LLAVA S.Aur� LLAV GS	-0.44	0.67	EXT
454	L	(P.Aer) LAVAG	-0.43	0.83	EXT
455	A	S.Malt AVAGS GA	-0.28	0.38	EXT
456	V	V	-0.16	0.94	EXT
457	A	A	0.03	0.40	EXT
458	G	S.Malt G� GAGK SL	0.40	0.03	EXT
459	S	S	0.97	0.04	EXT
460	T	(P.Aer)(S.Malt)� TGAGK	1.30	0.11	EXT
461	G	(P.Aer) GAGKTSLL V (S.Aur) GAGK (S.Malt) GAGK SL�� + GELE	1.55	0.06	EXT
462	A	S.Malt AGKTS	1.54	0.56	EXT
463	G	(S.Malt) GKTSL	1.03	0.07	EXT
464	K	(P.Aer) GKTSLL S.Malt KTSLL	0.38	0.08	EXT
465	T	T	-0.21	0.04	EXT
466	S	S	-0.78	0.03	EXT
467	L	S.Malt LLM V MGE+E	-1.24	0.75	EXT
468	L	L	-1.64	0.46	EXT
469	M	M	-1.83	0.74	EXT
470	V	V	-1.82	0.42	EXT
471	I	I	-1.93	0.75	EXT
472	M	S.Malt MGELE	-1.33	0.77	EXT
473	G	(P.Aer) GELEP-EG	-0.79	0.09	EXT
474	E	HSPD1 ELE� EG�� G IS P.Aer ELEP EG S.Aur ELEPS P.Aer ELEPS S.Malt ELE SEG	-0.10	0.11	EXT
475	L	S.Aur LEPSEG P.Aer LEPSE	0.59	0.95	EXT
476	E	(myelo) +PSEG P.Aer EPSEG S.Aur +PSEG S.Malt EP EG and EPSE	1.07	0.02	EXT
477	P	(P.Aer) PSEG-I	1.38	0.05	EXT
478	S	S	1.18	0.03	EXT
479	E	E	1.12	0.03	EXT
480	G	G	1.22	0.04	EXT
481	K	(S.Aur) KIKH	1.11	0.71	EXT
482	I	I	1.06	0.89	EXT
483	K	K	0.82	0.41	EXT
484	H	(rheum) HSGR	0.25	0.80	EXT
485	S	(TNF) S R� F S FS� I� G�� FGV�� +E+ �(Adren) �SG� SF�� Q� W�� T� E I	0.06	0.03	EXT
486	G	G	-0.41	0.09	EXT
487	R	R	-0.28	0.08	EXT
488	I	I	-0.36	0.57	EXT
489	S	S.Malt FCSQF	-0.34	0.04	EXT
490	F	F	-0.69	0.57	EXT
491	C	C	-0.72	0.04	EXT
492	S	S	-1.15	0.09	EXT
493	Q	Q	-1.09	0.05	EXT
494	F	F	-1.11	0.93	EXT
495	S	(P.Aer) SWIM	-0.69	0.03	EXT
496	W	W	-0.47	0.65	EXT
497	I	I	-0.24	0.11	EXT
498	M	M	-0.41	0.21	EXT
499	P	P	-0.11	0.02	EXT
500	G	G	-0.07	0.08	EXT
501	T	(S.Aur)TIKENI+ and T-KENI	0.34	0.02	EXT
502	I	(S.Aur)� IKENI	0.22	0.67	EXT
503	K	K	0.00	0.15	EXT
504	E	(P.Aer) ENIIF	-0.44	0.03	EXT
505	N	N	-0.58	0.06	EXT
506	I	I	-0.92	0.15	EXT
507	I	(rheum) IFGV (P.Aer) IFGVSYD S.Aur IFGVS S.Malt +FGVS	-0.63	0.20	EXT
508	F		-0.76	0.70	EXT
509	G	G	-0.63	0.03	EXT
510	V	V	-0.54	0.76	EXT
511	S	S	-0.29	0.03	EXT
512	Y	Y	0.03	0.87	EXT
513	D	D	0.29	0.06	EXT
514	E	S.Malt EYRYR	0.28	0.04	EXT
515	Y	Y	0.42	0.63	EXT
516	R	R	0.09	0.06	EXT
517	Y	(P.Aer) YRSV+	-0.11	0.89	EXT
518	R	R	-0.38	0.07	EXT
519	S	S	-0.62	0.07	EXT
520	V	V	-0.66	0.09	EXT
521	I	I	-0.66	0.90	EXT
522	K	K	-0.84	0.95	EXT
523	A	A	-0.66	0.93	EXT
524	C	C	-0.56	0.09	EXT
525	Q	Q	-0.16	0.19	EXT
526	L	L	-0.08	0.90	EXT
527	E	E	0.04	0.02	EXT
528	E	E	0.16	0.03	EXT
529	D	D	0.05	0.02	EXT
530	I	I	0.02	0.06	EXT
531	S	Adren SKF� K+�� L�� GI + S.Aur SKFAE S.Malt� SKFA+ P.Aer� SKFA+	0.47	0.02	EXT
532	K	K	0.47	0.60	EXT
533	F	F	0.57	0.96	EXT
534	A	A	0.43	0.25	EXT
535	E	E	0.29	0.02	EXT
536	K	K	0.03	0.36	EXT
537	D	(P.Aer) DN VLGEG GI [DNIV]	-0.30	0.12	EXT
538	N	(prot) N+VLG	0.01	0.03	EXT
539	I	(P.Aer) +VLGEG (Rheum) IVL +�� TLS�� R� L	0.23	0.07	EXT
540	V	S.Malt V GEGGI (HSPD1) V GE G TL	0.25	0.58	EXT
541	L	(P.Aer) LGEGGI-LSGGQR (S.Aur) LSGGQR	0.24	0.91	EXT
542	G	(S.Aur) GE G+ LSGG [GEGG--LSGGQ]	-0.17	0.21	EXT
543	E	(HSPD1) E GI L GG P.Aer EGGI LSGG S.Aur EGGI LS S.Malt EG ITL G	-0.19	0.03	EXT
544	G	S.Aur GG+TLSG S.Malt GGITLS	-0.16	0.07	EXT
545	G	S.Aur GI LSGG	0.20	0.02	EXT
546	I	(P.Aer) TLSGG+R (S.Aur) TLSGG+	0.65	0.44	EXT
547	T	(P.Aer) TLSGGQ (S.Malt)� TLSGGQ� R� LA AV	0.75	0.03	EXT
548	L	(P.Aer) LSGGQR-RI-LARA (GAD65) LSG +RA� (S.Aur) LSGGQR-RI (S.Malt) LSGGQR RI� AR�� KDA	0.74	0.98	EXT
549	S	(P.Aer) SGGQR-RI-LARA (S.Aur) SGGQ (S.Malt) SGGQR R� LARA	0.66	0.06	EXT
550	G	(P.Aer) SGGQR [GGQR]	0.44	0.13	EXT
551	G	(P.Aer) GQRA	0.66	0.04	EXT
552	Q	(P.Aer) QRAR S.Malt QRARI� (myelo) QR�� A ISL R	0.32	0.03	EXT
553	R	R	0.60	0.18	EXT
554	A	(myelo) A ISL R	0.13	0.60	EXT
555	R	(S.Aur) RIS ARA+ KDA (S.Malt) RISLA	-0.05	0.19	EXT
556	I	(TNF) IS LA AV (myelo) + LARAV (hspd1) L RA Y KD�� AD	-0.27	0.29	EXT
557	S	(P.Aer) SLARA	-0.53	0.02	EXT
558	L	(myelo) LARAV S.Malt LARAVY DA A.Aur and P.Aer LARAV	-0.79	0.61	EXT
559	A	A	-0.80	0.15	EXT
560	R	R	-0.74	0.82	EXT
561	A	S.Malt� +ARAVY DA	-0.21	0.07	EXT
562	V	V	-0.21	0.44	EXT
563	Y	Y	0.29	0.92	EXT
564	K	K	0.00	0.51	EXT
565	D	D	-0.20	0.08	EXT
566	A	S.Malt ADLYL	-0.54	0.24	EXT
567	D	D	-0.70	0.03	EXT
568	L	(P.Aer) L-LLD-PFG-LD (S.Aur) L+D PFG LD	-0.42	0.66	EXT
569	Y	Y	-0.36	0.96	EXT
570	L	(P.Aer) LL-SPFG (S.Aur) L+D PFG LD	-0.45	0.96	EXT
571	L	(P.Aer) LDSPFG	-0.59	0.79	EXT
572	D	D	-0.65	0.03	EXT
573	S	(adren) SPF Y�� LT K�� NK R� IL	-0.45	0.03	EXT
574	P	P	-0.48	0.02	EXT
575	F	F	-0.06	0.58	EXT
576	G	(calgran) G� D L + E F�� V K�� NK�� +�� ME L�� ADK L�� E	0.04	0.04	EXT
577	Y	Y	-0.42	0.93	EXT
578	L	(P.Aer) LDVL E (S.Malt) L VLTE and� LDVLT� (calgran) LD�� +K+� FE� +� LMA� T� S.Aur LD+LTEK	-0.53	0.97	EXT
579	D	(myelo) DVLT S.Malt DVL EK	-0.53	0.06	EXT
580	V	S.Malt +LTEK	-0.31	0.88	EXT
581	L	L	-0.34	0.97	EXT
582	T	(mucin)TEK� F S	-0.46	0.02	EXT
583	E	(hspd1) EK�� EI E P.Aer EKEIF S.Aur EKEI+E S.Malt EK+IF	-0.45	0.03	EXT
584	K	P.Aer and S.Aur KEIFE S.Malt KEIF	-0.48	0.97	EXT
585	E	E	-0.28	0.03	EXT
586	I	I	-0.17	0.28	EXT
587	F	F	-0.47	0.18	EXT
588	E	E	-0.85	0.03	EXT
589	S	S	-1.07	0.09	EXT
590	C	C	-1.55	0.04	EXT
591	V	P.Aer VCKLM S.Aur VC LMA S.Malt VCKL+	-1.50	0.20	EXT
592	C	S.Aur CKLM N S.Malt CK L� NK	-1.33	0.03	EXT
593	K	P.Aer KLMA K and KL+ANK S.Aur KL+ANK	-1.22	0.68	EXT
594	L	P.Aer LMA+KT	-1.09	0.59	EXT
595	M	P.Aer MA+KT S.Malt +ANKT	-0.89	0.42	EXT
596	A	P.Aer ANKT	-0.68	0.03	EXT
597	N	N	-0.78	0.03	EXT
598	K	K	-1.03	0.05	EXT
599	T	(S.Aur) T-ILVT	-0.85	0.02	EXT
600	R	R	-0.63	0.03	EXT
601	I	I	-0.48	0.61	EXT
602	L	L	-0.50	0.80	EXT
603	V	V	-0.75	0.54	EXT
604	T	T	-0.77	0.04	EXT
605	S	S	-0.81	0.07	EXT
606	K	K	-0.74	0.89	EXT
607	M	Calgran ME L�� ADK L�� E	-0.34	0.98	EXT
608	E	E	-0.04	0.04	EXT
609	H	H	-0.01	0.17	EXT
610	L	L	0.11	0.87	EXT
611	K	K	0.04	0.61	EXT
612	K	K	-0.15	0.19	EXT
613	A	�(S.Aur) ADKI	-0.63	0.08	EXT
614	D	D	-0.97	0.02	EXT
615	K	K	-1.09	0.36	EXT
616	I	I	-1.18	0.43	EXT
617	L	L	-1.13	0.82	EXT
618	I	I	-1.01	0.11	EXT
619	L	L	-1.00	0.92	EXT
620	H	H	-0.90	0.43	EXT
621	E	E	-0.69	0.04	EXT
622	G	G	-0.51	0.03	EXT
623	S	S	-0.18	0.03	EXT
624	S	S	0.23	0.03	EXT
625	Y	Y	0.37	0.85	EXT
626	F	(BPI) F+GTF P.Aer and S.Aur�� and S.Malt FYGTF	0.08	0.97	EXT
627	Y	Y	-0.05	0.95	EXT
628	G	(S.Aur) GT-SEL	-0.16	0.04	EXT
629	T	T	-0.49	0.05	EXT
630	F	F	-0.35	0.95	EXT
631	S	S	-0.04	0.12	EXT
632	E	GAD65 EL�� QNL+ +�� LM C P.Aer ELQ+LQ and ELQNL S.Aur� E QNLQ S.Malt ELQ LQ	-0.08	0.19	EXT
633	L	P.Aer L+NLQP S.Aur� L+NLQP and LQNLQ	0.10	0.98	EXT
634	Q	(mucin)� Q LQ D S�� + P.Aer QNL PD and QN+�� QPDF and� +NLQP S.Aur QNLQ DF and� QNL PD and QN Q DF S.Malt Q LQPD	0.07	0.24	EXT
635	N	P.Aer� NL+PD and N QP+F S.Malt +LQPDF S.Aur NL�� QPDF S.Malt +LQPDF and� NLQP+	0.53	0.03	EXT
636	L	S.Aur LQP+F S.Malt LQPDF and LQP+F	0.39	0.93	EXT
637	Q	Q	0.44	0.03	EXT
638	P	(rheum) PD FS�� G D P.Aer PDFSS S.Aur P+F S LM and PD� FS K+M S.Malt PDFS KL	0.69	0.05	EXT
639	D	P.Aer DF� KLM S.Aur� DFSS L S.Malt DFS KL and +F� KLM	0.68	0.06	EXT
640	F	P.Aer FSS LM S.Aur FSSKL	0.35	0.84	EXT
641	S	(BPI) SSKL (S.Aur) SSKL P.Aer SS LM and SSKL+ S.Malt SSKL+	0.24	0.02	EXT
642	S	P.Aer� and S.Aur and S.Malt SKLM	0.02	0.04	EXT
643	K	K	-0.07	0.96	EXT
644	L	L	-0.22	0.98	EXT
645	M	M	-0.06	0.96	EXT
646	G	G	-0.36	0.07	EXT
647	C	C	-0.26	0.03	EXT
648	D	D	-0.22	0.03	EXT
649	S	S	-0.13	0.02	EXT
650	F	F	0.25	0.17	EXT
651	D	D	0.26	0.03	EXT
652	Q	Q	0.45	0.06	EXT
653	F	(P.Aer) +FSAER	0.38	0.52	EXT
654	S	S	0.41	0.03	EXT
655	A	A	0.66	0.22	EXT
656	E	(myelo) ERR SI (GAD65) ER NS+ P.Aer ERR+SI S.Aur E RNSI and ERRN I S.Malt� +RRNS	0.53	0.13	EXT
657	R	S.Aur and P.Aer RRNSI S.Malt RR+SI	0.22	0.93	EXT
658	R	R	0.13	0.06	EXT
659	N	N	0.03	0.03	EXT
660	S	S	0.11	0.02	EXT
661	I	I	0.01	0.14	EXT
662	L	L	-0.35	0.82	EXT
663	T	T	-0.55	0.10	EXT
664	E	E	-0.70	0.17	EXT
665	T	T	-1.05	0.17	EXT
666	L	L	-0.77	0.93	EXT
667	H	H	-0.74	0.50	EXT
668	R	S.Malt RFSLEG	-0.58	0.93	EXT
669	F	F	-0.51	0.98	EXT
670	S	(P.Aer) SLEGDAP	-0.18	0.03	EXT
671	L	S.Malt L GDAPV	0.23	0.91	EXT
672	E	E	0.48	0.06	EXT
673	G	G	0.55	0.27	EXT
674	D	D	1.10	0.02	EXT
675	A	S.Malt APV SWTE	0.87	0.13	EXT
676	P	P	1.28	0.02	EXT
677	V	V	1.29	0.58	EXT
678	S	S	1.29	0.05	EXT
679	W	W	1.06	0.95	EXT
680	T	T	1.06	0.05	EXT
681	E	E	1.01	0.09	EXT
682	T	T	1.12	0.11	EXT
683	K	K	0.69	0.97	EXT
684	K	K	0.98	0.96	EXT
685	Q	Q	0.95	0.46	EXT
686	S	S	0.93	0.03	EXT
687	F	F	0.93	0.68	EXT
688	K	K	0.97	0.80	EXT
689	Q	Q	0.69	0.23	EXT
690	T	(S.Malt) TGE GE	0.73	0.03	EXT
691	G	G	0.78	0.09	EXT
692	E	E	1.15	0.03	EXT
693	F	hspd1 FG+ RKN S.Malt FG KRK and FG+ RK P.Aer FG+KRK and FGEKR S.Aur� F EKRK and� F� KRKN	1.15	0.92	EXT
694	G	S.Malt and P.Aer GEKRK S.Aur G KRKN	1.16	0.03	EXT
695	E	hspd1 EK�� SI�� I�� +� PL�� I ED D E L S.Malt� EKRKN P.Aer� EKRK+ S.Aur EKRK+	1.07	0.02	EXT
696	K	(P.Aer) KRKN-I	0.96	0.95	EXT
697	R	S.Aurs RKNSI P.Aer� and S.Malt RKNS+	0.51	0.43	EXT
698	K	(BPI) K SI N�� I�� QK� L M G	0.44	0.28	EXT
699	N	N	0.37	0.03	EXT
700	S	S	0.26	0.03	EXT
701	I	I	0.02	0.14	EXT
702	L	L	0.08	0.23	EXT
703	N	N	-0.03	0.02	EXT
704	P	P	-0.33	0.07	EXT
705	I	I	-0.39	0.16	EXT
706	N	N	-0.14	0.03	EXT
707	S	S	-0.25	0.02	EXT
708	I	I	-0.33	0.92	EXT
709	R	R	-0.66	0.87	EXT
710	K	K	-0.73	0.64	EXT
711	F	F	-0.84	0.96	EXT
712	S	S	-0.67	0.02	EXT
713	I	I	-0.30	0.15	EXT
714	V	V	-0.17	0.83	EXT
715	Q	Q	-0.37	0.39	EXT
716	K	K	0.06	0.96	EXT
717	T	T	-0.08	0.09	EXT
718	P	P	0.30	0.04	EXT
719	L	(rheum)LQMN (prot) LQM G (mucin) LQ N�� ED S.Malt LQM G S.Aur and P.Aer� LQMNG	0.52	0.81	EXT
720	Q	S.Malt QMNG	0.33	0.13	EXT
721	M	M	0.35	0.85	EXT
722	N	N	0.38	0.08	EXT
723	G	G	0.59	0.10	EXT
724	I	I	1.03	0.96	EXT
725	E	E	1.30	0.05	EXT
726	E	(P.Aer) EDSDE	1.70	0.06	EXT
727	D	(P.Aer) D DEPLER	1.76	0.07	EXT
728	S	(myelo) S+EPL R L� P.Aer SDEPL and SDE L�� ERR S.Aur SDEPL+ S.Malt DEP+ ERRL	1.55	0.03	EXT
729	D	P.Aer DEPLER and ++PLERRL S.Aur� DE LER RL	1.87	0.02	EXT
730	E	(P.Aer) EPL-RRLS S.Aur EPLER S.Malt EPL RRL	1.59	0.02	EXT
731	P	S.Malt� P ERRLSLV P.Aer PLERRL S.Malt PLERR	1.43	0.06	EXT
732	L	(P.Aer) LERRL and L+RRLS S.Aur LERRL	0.77	0.94	EXT
733	E	E	0.49	0.03	EXT
734	R	S.Malt RRL�� PDSE+G+AI� R+� IS	-0.16	0.94	EXT
735	R	R	-0.46	0.41	EXT
736	L	(BPI) L�� P� + Q� A+LP� S� S	-0.52	0.96	EXT
737	S	S	-0.05	0.03	EXT
738	L	L	0.07	0.97	EXT
739	V	V	0.39	0.84	EXT
740	P	S.Malt PDSEQ	0.59	0.09	EXT
741	D	D	1.14	0.08	EXT
742	S	S	1.36	0.08	EXT
743	E	(P.Aer) EQGEA-L (GAD65) E G A LPR	1.58	0.05	EXT
744	Q	Q	1.47	0.06	EXT
745	G	G	1.15	0.31	EXT
746	E	(P.Aer) EAIL	0.77	0.05	EXT
747	A	A	0.53	0.69	EXT
748	I	(BPI) +LPR+�� LQ	0.10	0.06	EXT
749	L	(myelo) LPRI�� TG T	-0.14	0.26	EXT
750	P	(BPI)� P� SV� TG T	-0.56	0.04	EXT
751	R	R	-0.96	0.25	EXT
752	I	I	-0.83	0.16	EXT
753	S	S	-0.46	0.03	EXT
754	V	V	0.06	0.74	EXT
755	I	I	0.25	0.96	EXT
756	S	S	0.39	0.17	EXT
757	T	S.Malt TGP L AR S.Malt and S.Aur and P.Aer TGPTL	0.42	0.24	EXT
758	G	G	0.52	0.12	EXT
759	P	S.Malt PTLQA	0.67	0.04	EXT
760	T	(P.Aer) TL� QARRR� (rheum) TL� R� QSV S.Aur TLQAR�� RR S.Malt TLQ RRR+	0.94	0.05	EXT
761	L	(P.Aer) LQARRR and LQAR-RQ (S.Malt) LQ� ARRR	0.91	0.97	EXT
762	Q	P.Aer +ARRR S.Malt� QARRRQ	0.76	0.51	EXT
763	A	(P.Aer) AR RRQSV S.Aur� ARRR+S+	0.55	0.94	EXT
764	R	S.Malt R RQSV	0.45	0.52	EXT
765	R	(P.Aer) RRQSVLN	0.10	0.15	EXT
766	R	R	-0.12	0.84	EXT
767	Q	Q	-0.26	0.03	EXT
768	S	S	-0.56	0.02	EXT
769	V	V	-0.83	0.20	EXT
770	L	L	-0.89	0.75	EXT
771	N	(P.Aer) +NLMT	-1.01	0.04	EXT
772	L	(tnf) L+TH�� I R�� KV L P.Aer LMTHS S.Malt LM HS S.Aur LMTH	-0.99	0.92	EXT
773	M	M	-1.13	0.93	EXT
774	T	T	-0.81	0.05	EXT
775	H	H	-0.32	0.41	EXT
776	S	S	-0.05	0.04	EXT
777	V	S.Malt� VNQGQ	0.45	0.96	EXT
778	N	N	0.79	0.03	EXT
779	Q	�(mucin) QGQ+� S.Aur QGQNI S.Malt� +GQNI P.Aer +GQNI and QG+NI	0.56	0.03	EXT
780	G	G	0.58	0.09	EXT
781	Q	Q	0.48	0.07	EXT
782	N	(hspd1) N HRK P.Aer and S.Aur NI+RK S.Malt NI RK and NIHR	0.69	0.03	EXT
783	I	I	0.64	0.45	EXT
784	H	H	0.65	0.40	EXT
785	R	R	0.53	0.28	EXT
786	K	K	0.55	0.76	EXT
787	T	T	0.54	0.06	EXT
788	T	T	0.83	0.03	EXT
789	A	A	0.95	0.32	EXT
790	S	S	0.76	0.05	EXT
791	T	(P.Aer) TRKV (S.Malt) TR VSLAP+A L E +	0.71	0.26	EXT
792	R	R	0.40	0.97	EXT
793	K	K	0.33	0.85	EXT
794	V	(P.Aer) VS-APQA-LT and VSLAPQ S.Aur and S.Malt VSLAP� (mucin) V LAP	0.35	0.95	EXT
795	S	(P.Aer) SLAP	0.45	0.02	EXT
796	L	(P.Aer) LAPQ --NLT-LD--S RL S.Malt LA QANL	0.42	0.90	EXT
797	A	A	0.49	0.09	EXT
798	P	(tnf) PQA�� +L�� RR P.Aer and S.Malt PQANL S.Aur PQAN+	0.19	0.10	EXT
799	Q	Q	0.39	0.12	EXT
800	A	A	0.44	0.19	EXT
801	N	N	0.36	0.06	EXT
802	L	L	0.39	0.74	EXT
803	T	T	0.02	0.24	EXT
804	E	E	-0.33	0.02	EXT
805	L	L	-0.39	0.97	EXT
806	D	D	-0.53	0.02	EXT
807	I	I	-0.30	0.43	EXT
808	Y	Y	-0.59	0.58	EXT
809	S	S.Malt SRRL QE	-0.58	0.12	EXT
810	R	(P.Aer) RRLS+E	-0.20	0.97	EXT
811	R	R	-0.07	0.63	EXT
812	L	L	0.32	0.97	EXT
813	S	S	0.56	0.02	EXT
814	Q	(P.Aer) QETGL	0.27	0.14	EXT
815	E	E	0.41	0.04	EXT
816	T	(BPI) TG +E+S E N P.Aer TGL ISEE S.Malt TGL+IS S.Aur T LE SEE+	0.16	0.06	EXT
817	G	S.Malt GLEISE P.Aer� GLEISEE S.Aur GL+� EEI	0.58	0.09	EXT
818	L	S.Malt LEISEE P.Aer L+ISEE S.Aur L ISEE	0.58	0.97	EXT
819	E	S.Malt E SEEI P.Aer EISEE S.Aur E SEEIN	0.63	0.03	EXT
820	I	S.Malt ISEEI P.Aer ISE IN S.Aur ISE IN	0.23	0.79	EXT
821	S	(tnf) S EIN� D P.Aer SEE�� NEED S.Malt SE+ NE+D and SE+IN S.Aur SEEINE D	0.27	0.03	EXT
822	E	P.Aer EEINE S.Malt EINE D	0.32	0.05	EXT
823	E	P.Aer EINEE+ S.Aur EI EED	0.74	0.03	EXT
824	I	P.Aer and S.Aur INEED S.Malt IN+ED	0.83	0.77	EXT
825	N	N	0.87	0.04	EXT
826	E	E	0.74	0.02	EXT
827	E	E	0.62	0.05	EXT
828	D	D	0.31	0.03	EXT
829	L	L	0.14	0.80	EXT
830	K	K	-0.34	0.26	EXT
831	E	E	-0.43	0.09	EXT
832	C	C	-0.43	0.03	EXT
833	F	F	-0.69	0.62	EXT
834	F	F	-0.39	0.15	EXT
835	D	(BPI) DDM�� ES�� TT�� T+L� +� S.Malt DDMES S.Aur DD�� ESIPA T P.Aer DDM+ IP V	-0.27	0.03	EXT
836	D	S.Malt DMESI S.Aur� D+ESI AV P.Aer +M+SIP VT	-0.34	0.08	EXT
837	M	S.Malt ME� PAV T S.Aur +ESIPA P.Aer MES PAV	-0.13	0.17	EXT
838	E	S.Aur ESIPA T P.Aer +S+PAVT and ES+P VT S.Malt ESI�� AVTT	0.24	0.02	EXT
839	S	S.Malt SIPA T WN S.Aur SIPA� V T P.Aer SI AVT	0.57	0.02	EXT
840	I	P.Aer and S.Malt� IPAVT S.Aur I AVTT	0.57	0.12	EXT
841	P	P.Aer and S.Malt PAVTT S.Aur PA+TT	0.50	0.02	EXT
842	A	S.Malt� and S.Aur and P.Aer AVTT	0.40	0.06	EXT
843	V	V	0.44	0.22	EXT
844	T	T	0.33	0.03	EXT
845	T	T	0.29	0.09	EXT
846	W	W	-0.09	0.95	EXT
847	N	(P.Aer) NTYLR	-0.23	0.03	EXT
848	T	T	-0.43	0.15	EXT
849	Y	Y	-0.82	0.84	EXT
850	L	(BPI) LR�� + K�� F L�� FL EVA P.Aer LRYIT S.Aur LRYI V S.Malt LRYIT	-0.94	0.95	EXT
851	R	P.Aer� RY+TV S.Malt� RY� TVHK	-0.97	0.43	EXT
852	Y	S.Malt YITVH P.Aer YITV	-1.11	0.98	EXT
853	I	(hspd1) +TV KS S.Malt IT HKS S.Aur +TVHKS� P.Aer ITV+KS	-1.14	0.05	EXT
854	T	(myelo) TV K� IF P.Aer TVHKS S.Aur� T+HKS and TVHKS +F S.malt TV H SLIF	-1.02	0.02	EXT
855	V	P.Aer VHKSL S.Aur VH SLI S.Malt V+ SL+F	-1.06	0.94	EXT
856	H	P.Aer� H SLIF S.Aur HK LIF S.Malt HKSL	-1.34	0.22	EXT
857	K	P.Aer� and S.Malt KSLIF S.Aur KSL+F	-1.63	0.50	EXT
858	S	S	-1.68	0.06	EXT
859	L	L	-2.07	0.88	TM
860	I	I	-2.30	0.08	TM
861	F	F	-2.77	0.17	TM
862	V	V	-2.99	0.13	TM
863	L	L	-3.44	0.65	TM
864	I	I	-3.45	0.28	TM
865	W	W	-3.52	0.79	TM
866	C	C	-3.45	0.02	TM
867	L	S.Malt LV FLAE	-3.44	0.76	TM
868	V	(BPI) V� L ++�� V�� L�� N� LQ KG�� T� R�� Y V+	-3.14	0.21	TM
869	I	I	-2.65	0.79	TM
870	F	(BPI )FL EVA P.Aer and S.Malt� FLAEVA S.Aur FL EVA	-2.27	0.28	TM
871	L	(myelo) L EV� SLV	-2.02	0.83	TM
872	A	(P.Aer) AEVAASL	-1.64	0.21	TM
873	E	(P.Aer) EVAASL	-1.21	0.02	TM
874	V	(P.Aer) VAAS-VVL S.Malt VAASL VLW	-1.09	0.76	TM
875	A	S.Aur and S.Malt and P.Aer AASLV	-0.97	0.04	TM
876	A	(P.Aer) ASLV LWLLG T [A SLVVL] (BPI) ASL VL�� G�	-0.92	0.10	TM
877	S	S	-1.22	0.02	TM
878	L	L	-1.74	0.90	TM
879	V	V	-2.02	0.35	TM
880	V	V	-2.34	0.80	TM
881	L	(P.Aer) LWLL	-2.23	0.90	TM
882	W	W	-2.04	0.55	IN
883	L	(P.Aer) LLG--PLQ S.Malt� LLGNTP	-1.52	0.88	IN
884	L	L	-1.13	0.95	IN
885	G	G	-0.95	0.12	IN
886	N	(myelo) NT�� G� T S NN�� SY	-0.33	0.05	IN
887	T	T	0.32	0.04	IN
888	P	P	0.89	0.32	IN
889	L	L	1.38	0.97	IN
890	Q	Q	1.56	0.14	IN
891	D	D	1.51	0.15	IN
892	K	K	1.45	0.55	IN
893	G	P.Aer GNST S RN+	1.38	0.06	IN
894	N	P.Aer� N THSR	1.62	0.03	IN
895	S	(P.Aer) S HSRN	1.50	0.04	IN
896	T	P.Aer THSR N	1.46	0.38	IN
897	H	P.AER HSRN	1.41	0.40	IN
898	S	S	1.35	0.10	IN
899	R	R	1.05	0.34	IN
900	N	N	0.78	0.03	IN
901	N	N	0.39	0.02	TM
902	S	S	0.04	0.02	TM
903	Y	Y	-0.38	0.94	TM
904	A	A	-0.43	0.05	TM
905	V	V	-0.48	0.80	TM
906	I	I	-0.45	0.81	TM
907	I	(rheum) IT� SSY P.Aer ITST	-0.43	0.14	TM
908	T	(gad65) TST�� F Y	-0.23	0.03	TM
909	S	(rheum )STS YY	-0.24	0.05	TM
910	T	T	-0.17	0.19	TM
911	S	S	-0.12	0.03	TM
912	S	S	-0.21	0.03	TM
913	Y	Y	-0.49	0.74	TM
914	Y	Y	-0.98	0.72	TM
915	V	V	-1.31	0.27	TM
916	F	F	-1.69	0.24	TM
917	Y	S.Malt YIY G V�� ADT L M	-1.77	0.65	TM
918	I	I	-1.75	0.17	TM
919	Y	Y	-1.50	0.95	TM
920	V	V	-1.11	0.92	TM
921	G	(hspd1) GVA� LL P.Aer GV DTLL S.Aur G+ DTLL S.Malt GVA DTLL	-0.70	0.22	TM
922	V	(P.Aer) VADTLLA S.Malt VADTL S.Aur VADT+ S.Malt VA+TLL	-0.74	0.83	TM
923	A	P.Aer ADTLL S.Aur ADTL+	-0.74	0.31	TM
924	D	(gad65) D LLA P.Aer and S.Malt DTLLA� S.Aur DTLL	-0.71	0.03	EXT
925	T	(P.Aer) TLLA+GF	-0.72	0.13	EXT
926	L	(P.Aer) TLLAM	-0.78	0.75	EXT
927	L	(P.Aer) LAMG (S.Aur) LAM F� G	-1.04	0.81	EXT
928	A	A	-1.36	0.18	EXT
929	M	(P.Aer) MGF RG	-1.57	0.90	EXT
930	G	(P.Aer) GFFRGLP	-1.48	0.05	EXT
931	F	F	-1.40	0.57	EXT
932	F	(S.Aur) LAM F� G	-1.03	0.18	EXT
933	R	R	-1.19	0.17	EXT
934	G	S.Malt GLPLV+	-1.05	0.03	EXT
935	L	L	-1.18	0.67	EXT
936	P	P	-0.91	0.03	EXT
937	L	L	-0.98	0.78	EXT
938	V	(BPI) VH� I� SK+�� L HK� �S L�� M� P.Aer +HTLIT S.Aur� VH LIT S S.Malt� VH L�� S I HH	-1.22	0.50	EXT
939	H	P.Aer HT+ITV S.Aur HTLIT�� S I S.Malt� H LITV	-1.36	0.04	EXT
940	T	(rheum) TL+TVS P.Aer TL+TVS S.Aur and S.Malt TLITV S.Aur� TLITV S I S.Malt TLI VS	-1.30	0.06	EXT
941	L	P.Aer and S.Aur and S.Malt LITVS	-1.25	0.87	EXT
942	I	P.Aer +TV�� KILH S.Aur I +SKIL S.Malt +TVS IL	-0.99	0.97	EXT
943	T	P.Aer TVS IL S.Aur� TVSKI S.Malt TVSK+L	-1.20	0.08	EXT
944	V	P.Aer VS K+� LHHK S.Aur� VSKIL S.Malt +SKIL	-1.42	0.82	EXT
945	S	P.Aer SKIL+� S.Aur SK LHH S.Malt SKIL�� HH	-1.47	0.10	EXT
946	K	P.Aer and S.Malt KILH S.Aur KI HH	-1.27	0.95	EXT
947	I	P.Aer ILHH and S.Malt S.Aur ILHHK	-1.02	0.68	EXT
948	L	P.Aer� and S.Aur LHHK	-1.23	0.95	EXT
949	H	H	-1.41	0.04	EXT
950	H	H	-1.60	0.13	EXT
951	K	K	-1.62	0.96	EXT
952	M	M	-1.51	0.94	EXT
953	L	L	-1.43	0.91	EXT
954	H	H	-1.18	0.10	EXT
955	S	S	-1.04	0.05	EXT
956	V	V	-0.87	0.84	EXT
957	L	L	-0.63	0.94	EXT
958	Q	Q	-0.17	0.03	EXT
959	A	S.Malt� APMSTL T	-0.02	0.17	EXT
960	P	S.Malt PMSTL	-0.18	0.09	EXT
961	M	(hspd1) +STL� N LK G P.Aer M TLNT�� LK S.Aur +S LNTLK S.Malt MSTL N LK	0.05	0.46	EXT
962	S	S.Malt S LNT L AGGI P.Aer ST+NT KAG S.Aur S LNTLK	0.32	0.03	EXT
963	T	(P.Aer) TLNT S.Aur TLNTL S.Malt TLNT+	-0.04	0.23	EXT
964	L	P.Aer LNTL S.Aur and S.Malt LNTLK	0.04	0.97	EXT
965	N	P.Aer +TLKAG� S.Aur NTLKA S.Malt +TL AG	-0.05	0.04	EXT
966	T	P.Aer and S.Aur TLKA S.Malt TLKAG	0.10	0.03	EXT
967	L	P.Aer and S.Aur and S.Malt� LKAG	0.04	0.98	EXT
968	K	K	-0.18	0.48	EXT
969	A	(rheum) A GI +RFS P.Aer AG IL�� NRFS and AGGIL S.Aur AGG IL RF S.Malt AGGILN	-0.25	0.48	EXT
970	G	(S.Aur) GGIL P.Aer GG+L+RF� S.Aur GGI+NR S.Malt GGI NRFS	-0.33	0.03	EXT
971	G	P.Aer G LNRF� S.Aur� GI NRF S.Malt� GIL RF	-0.36	0.03	EXT
972	I	P.Aer ILNR S� S.Aur IL RFS S.Malt� ILNR	-0.37	0.08	EXT
973	L	P.Aer LNRFS S.Aurand S.Malt� LNRF	-0.35	0.72	EXT
974	N	P.Aer and S.Aur and S.Malt NRFS	-0.33	0.15	EXT
975	R	R	-0.27	0.52	EXT
976	F	F	-0.59	0.75	EXT
977	S	S	-0.52	0.02	EXT
978	K	K	-0.54	0.52	EXT
979	D	(S.Aur) LTI+DF	-0.76	0.06	EXT
980	I	(S.Aur) I ILD+LL	-0.65	0.92	EXT
981	A	S.Malt AILD+	-0.35	0.04	EXT
982	I	I	-0.64	0.79	EXT
983	L	L	-0.96	0.92	EXT
984	D	(rheum) DDLLP P.Aer, S.Aur and S.Malt� DDLLP	-1.20	0.05	EXT
985	D	D	-1.22	0.04	EXT
986	L	S.Malt LLPLT	-1.05	0.13	TM
987	L	L	-1.05	0.14	TM
988	P	P	-1.11	0.02	TM
989	L	(S.Aur) LTI+DFI and LTI+DF (mucin) LTI D	-1.18	0.83	TM
990	T	T	-1.57	0.06	TM
991	I	I	-1.70	0.32	TM
992	F	F	-1.53	0.66	TM
993	D	D	-1.92	0.04	TM
994	F	(P.Aer) FIQL	-2.09	0.73	TM
995	I	S.Malt I LLLI	-2.63	0.54	TM
996	Q	Q	-2.78	0.05	TM
997	L	(P.Aer) LLLI	-2.73	0.80	TM
998	L	L	-3.01	0.94	TM
999	L	(BPI) L V� AI� AV A�� P S.Malt L VIGA�� AVLQP P.Aer L VIGA S.Aur LIVIG IAVV	-2.69	0.40	TM
1000	I	S.Malt IV� A AV P.Aer� +VIGA ��VA S.Aur IVIGAI V� VL	-2.42	0.17	TM
1001	V	(adren) VI AIA�� LQ S.Malt VIG IA++A�� VL P.Aer VI� IAV� AV S.Aur VIGAI V+A	-2.53	0.08	TM
1002	I	(S.Malt) IGAIA and IG� AV A +L P P.Aer I A AVVA S.Aur I AIAVVA	-2.20	0.05	TM
1003	G	S.Malt GA� VV� L P.Aer GA AVVA S.Aur GA AVV	-1.97	0.04	TM
1004	A	S.Malt AIA�� VL P.Aer AI VV�� VLQ S.Aur AIAVVA	-1.67	0.05	TM
1005	I	S.Malt IAVVA P.Aer I VVAV S.Aur IA VVAVL	-1.38	0.76	TM
1006	A	S.Malt AVVAVL� P.Aer AVVAV S.Aur A +AVL	-1.33	0.10	TM
1007	V	S.Malt VVAVL P.Aer VVAV QP S.Aur VVAV QP	-1.24	0.70	TM
1008	V	S.Malt VAVLQP P.Aer and S.Aur VAVL	-1.14	0.85	TM
1009	A	S.Malt and P.Aer AVLQ S.Aur AV QP	-1.09	0.09	IN
1010	V	(BPI) VLQP� S.Malt and P.Aer VLQPY S.Aur +LQPY	-0.94	0.18	IN
1011	L		-1.08	0.70	IN
1012	Q	(hspd1) QP�� VIV (S.Aur) QPYIF A + (adren) Q Y�� A�� IV F�� IM�� Y�� F +�� QL�� + SEGR P.Aer QPYI+� TV S.Malt Q Y FV�� ATV S.Aur� QP�� Y IFVA V	-1.23	0.02	IN
1013	P	P.Aer� P+IF AT and PY FVAT S.Malt� PYI VA S.Aur PY F�� V VI	-1.25	0.03	IN
1014	Y	(S.Aur) YIF+A P.Aer YIF AT S.Malt YI� FV� VP	-1.19	0.79	IN
1015	I	(P.Aer) IVAFI+L S.Malt +FV TV V V and IF ATV S.Aur IFVA	-0.84	0.14	TM
1016	F	(P.Aer) FVAT+ and +VATVPV+ S.Malt F A TVPV S.Aur FV T P IV	-0.70	0.28	TM
1017	V	P.Aer� VA VPV V S.Malt VATV VI S.Aur V TVPV	-0.80	0.62	TM
1018	A	P.Aer ATVPV V S.Malt ATV VI S.Aur� A VP IV	-0.97	0.36	TM
1019	T	P.Aer� TV VIV S.Malt TVPV+� S.Aur TV VIV	-1.10	0.03	TM
1020	V	P.Aer and S.Aur VPVIV S.Malt VPVI+	-1.12	0.63	TM
1021	P	P.Aer and S.Malt PVIV	-0.94	0.04	TM
1022	V	V	-1.12	0.55	TM
1023	I	(P.Aer) IVAFI+L AY [IVAFI+L]	-1.42	0.07	TM
1024	V	V	-1.89	0.29	TM
1025	A	A	-2.22	0.24	TM
1026	F	(Calgran) FIML A�� S++� +�� EG� S.Malt FI+LRA S.Aur F+MLR P.Aer FIML�� RA S.Aur FIML	-2.30	0.51	TM
1027	I	P.Aer IMLRA	-2.27	0.21	TM
1028	M	M	-2.27	0.91	TM
1029	L	S.Malt LRAYF	-2.33	0.91	TM
1030	R	R	-2.46	0.55	TM
1031	A	A	-2.03	0.41	TM
1032	Y	Y	-1.54	0.58	TM
1033	F	F	-1.02	0.14	TM
1034	L	(myelo) �L�� ++ KQL p.Aer LQTSQ S.Aur LQ SQQL S.Malt LQTS� QQL	-0.53	0.83	TM
1035	Q	P.Aer QTSQ+L S.Aur QT QQL S.Malt QTSQQ	-0.36	0.06	EXT
1036	T	P.Aer� TSQQL S.Aur and S.Malt TS+QL	-0.46	0.21	EXT
1037	S	(myelo) S QL� L P.Aer SQQL QL S.Aur S QLKQL S.Malt SQQL QL	-0.26	0.19	EXT
1038	Q	(P.Aer) QQL-QLE--GR S.Aur +QLKQL S.Malt QQLKQ	0.09	0.63	EXT
1039	Q	S.malt QLKQ� E EGRS S.Aur QLKQL	0.20	0.76	EXT
1040	L	L	0.32	0.97	EXT
1041	K	K	0.38	0.93	EXT
1042	Q	Q	0.42	0.31	EXT
1043	L	(P.Aer) LESE	0.50	0.97	EXT
1044	E	P.Aer ESEGRS S.Aur ESEGR	0.64	0.02	EXT
1045	S	(Adren) SEGR S.Malt amd P.Aer SEGRS� S.Aur SEGR	1.07	0.08	EXT
1046	E	E	1.09	0.04	EXT
1047	G	G	0.91	0.05	EXT
1048	R	R	0.92	0.05	EXT
1049	S	S	0.68	0.02	EXT
1050	P	P	0.40	0.03	EXT
1051	I	(gad2) I� H� T LK�� G�� YF� L�� L++�� A+W�� F�� I� +FV	-0.14	0.60	EXT
1052	F	F	-0.50	0.25	EXT
1053	T	T	-0.78	0.03	EXT
1054	H	H	-0.93	0.31	EXT
1055	L	L	-1.16	0.98	EXT
1056	V	V	-0.98	0.94	EXT
1057	T	S.Malt TSLKG W	-0.75	0.67	EXT
1058	S	S	-0.89	0.10	EXT
1059	L	L	-1.04	0.89	EXT
1060	K	K	-0.76	0.82	EXT
1061	G	G	-0.85	0.08	EXT
1062	L	L	-0.84	0.58	EXT
1063	W	W	-0.98	0.31	EXT
1064	T	(P.Aer) TLRAF	-1.01	0.03	EXT
1065	L	(myelo) LR�� R P+� T� P.Aer LR F RQPY and LRAFG�� RQ S.Aur LR F�� GRQPY S.Malt� RQPYF+T	-0.95	0.97	EXT
1066	R	S.Malt RAFGRQ P.Aer RAFGR P S.Aur RA+ GR PY	-0.81	0.89	EXT
1067	A	P.Aer AF RQP S.Aur AFGRQ� FE S.Malt AF� QPY�� FE	-0.36	0.40	EXT
1068	F	P.Aer F R QPY ET and FGRQP S.Aur FGR PY S.Malt� +GRQP	-0.02	0.31	EXT
1069	G	P.Aer GRQ Y+E S.Aur GRQ Y+	0.03	0.07	EXT
1070	R	S.Malt RQPYF+T	0.16	0.08	EXT
1071	Q	(BPI) QPYF+TL S.Malt QPYF+T P.Aer QPYFE S.Aur� QP� YFET	0.24	0.03	EXT
1072	P	S.Malt PYFETL S.Aur PYF TL P.Aer PYFE TL	0.28	0.03	EXT
1073	Y	S.Aur YFETL	0.21	0.96	EXT
1074	F	F	-0.21	0.79	EXT
1075	E	(tnf) E L� K�� +�� L+LS S.Aur and P.Aer ETLFH S.Malt ET LFHK	-0.46	0.02	EXT
1076	T	T	-0.71	0.03	EXT
1077	L	L	-0.82	0.97	EXT
1078	F	F	-1.15	0.88	EXT
1079	H	H	-1.00	0.54	EXT
1080	K	K	-1.37	0.98	EXT
1081	A	A	-1.35	0.17	EXT
1082	L	L	-1.00	0.78	EXT
1083	N	N	-0.65	0.02	EXT
1084	L	(adren) L+T� N F S.Malt LH AN W S.Aur +HT +W P.Aer L TANW	-0.45	0.88	EXT
1085	H	(S.Aur) HT NWF S.Malt HTAN P.Aer� HTA+W	-0.73	0.04	EXT
1086	T	S.Malt TA+WF P.Aer TA+WF	-1.01	0.03	EXT
1087	A	A	-1.12	0.08	EXT
1088	N	N	-1.36	0.05	EXT
1089	W	W	-1.36	0.90	EXT
1090	F	F	-1.34	0.06	EXT
1091	L	L	-1.40	0.85	EXT
1092	Y	Y	-1.68	0.87	EXT
1093	L	S.Malt L TLRWF	-1.84	0.94	EXT
1094	S	S	-1.86	0.03	EXT
1095	T	(P.Aer) TLRW (gad2) TL�� Q� M I + +V+ P.Aer TLRW�� F+ R S.Aur TLR FQ S.Malt TLR FQ	-1.84	0.06	EXT
1096	L	P.Aer LRWF�� QM S.Aur LR F+MR S.Malt LR W QM	-1.43	0.90	EXT
1097	R	P.Aer RWF� RI S.Malt RWF� RI	-1.46	0.10	EXT
1098	W	P.Aer WF+M I S.Malt W QMRI	-1.14	0.95	TM
1099	F	P.Aer FQMR S.Aur FQMR+	-1.48	0.20	TM
1100	Q	Q	-1.47	0.03	TM
1101	M	M	-1.51	0.63	TM
1102	R	(P.Aer) RIEM	-1.83	0.05	TM
1103	I	(P.Aer) RI-MIF	-1.96	0.22	TM
1104	E	E	-1.99	0.03	TM
1105	M	M	-2.41	0.08	TM
1106	I	I	-2.62	0.04	TM
1107	F	F	-3.01	0.07	TM
1108	V	V	-3.05	0.04	TM
1109	I	I	-3.16	0.33	TM
1110	F	F	-3.07	0.26	TM
1111	F	F	-2.74	0.15	TM
1112	I	I	-2.60	0.61	TM
1113	A	A	-2.57	0.08	TM
1114	V	(P.Aer) VTFI	-2.22	0.68	TM
1115	T	(P.Aer) TFI-ILT-G	-2.08	0.10	TM
1116	F	F	-1.96	0.82	TM
1117	I	I	-1.55	0.71	TM
1118	S	(hspd1) S LTT E S.Malt SILT GE S.Aur and P.Aer SILTT	-1.32	0.04	TM
1119	I	S.Malt� ILTTG+ S.Aur ILTTG	-0.88	0.90	TM
1120	L	(gad65) L�� +GE�� L�� MNI+� LQ� V S (myelo) L�� E� G� G +L�� LA�� M�� Q�� ID+�� M� VS�� K (hspd1) LT�� +� +GI�� TL�� M�� A V� S� V+� M S S V�� F++M S.Malt and S.Aur and P.Aer� LTTGE	-0.56	0.97	TM
1121	T	(rheum)TTGE S.Malt TTGEG+� S.Aur TTGE E and TTGEG P.Aer TTGEGE	0.02	0.27	IN
1122	T	T	0.58	0.39	IN
1123	G	G	0.82	0.34	IN
1124	E	E	1.25	0.03	IN
1125	G	G	1.41	0.05	IN
1126	E	(P.Aer) EGRV	1.36	0.02	IN
1127	G	(prot) GRVG P.Aer GRVGI S.Malt GR+GI S.Aur and P.Aer GRVGI	0.89	0.05	IN
1128	R	S.Malt RVGI LTL� N	0.37	0.04	IN
1129	V	V	-0.34	0.18	TM
1130	G	G	-0.66	0.02	TM
1131	I	I	-1.28	0.38	TM
1132	I	I	-1.51	0.05	TM
1133	L	L	-1.87	0.80	TM
1134	T	T	-1.76	0.03	TM
1135	L	(S.Aur) LAMN	-2.06	0.98	TM
1136	A	A	-1.87	0.06	TM
1137	M	M	-1.61	0.13	TM
1138	N	N	-1.16	0.03	TM
1139	I	I	-1.32	0.42	TM
1140	M	M	-0.88	0.83	TM
1141	S	S	-1.09	0.02	TM
1142	T	T	-0.85	0.04	TM
1143	L	(adren) L W�� VNS� +�� L�� S� F�� S K Y NG P.Aer LQW +N and LQ AVNS S.Aur LQ AVN S.Malt LQWA++S	-0.93	0.94	TM
1144	Q	P.Aer� +WAVN and QWA� SS S.Aur Q AV SS S.Malt Q AV SS	-0.47	0.04	TM
1145	W	P.Aer WA+NS S.Aur WAV SS S.Malt� W AV SS	-0.23	0.51	TM
1146	A	S.Aur AVNSS S.Malt AVNS P.Aer AV+SS	-0.07	0.04	TM
1147	V	V	-0.29	0.83	TM
1148	N	N	0.11	0.03	TM
1149	S	(rheum) SS + +�� RS�� F F S.Aur S IDV SL P.Aer SSI+VD L S.Malt SSID+ SL	-0.08	0.07	EXT
1150	S	P.Aer SID+DS S.Aurs SIDV DSL S.Malt SI VDS	0.38	0.04	EXT
1151	I	S.Malt IDV+S�� SVSRV� P.Aer� +DVDSL S.Aur +DVDSL S.Malt I VDSL	0.39	0.90	EXT
1152	D	P.Aer DVDSL S.Aur DV+SL S.Malt� +VDSL	0.19	0.02	EXT
1153	V	V	-0.15	0.79	EXT
1154	D	D	-0.31	0.03	EXT
1155	S	S	-0.41	0.03	EXT
1156	L	L	-0.32	0.56	EXT
1157	M	(hspd1) MR VSRV and� M� V� V�� ++� + KP�� T P�� Q ��+ S.Malt MRSVS V and� MRSV� VF P.Aer MR VSRV S.Aur MRSVS and +RS+SRV	-0.44	0.77	EXT
1158	R	S.Malt RSVSRV	-0.39	0.46	EXT
1159	S	(BPI) S+S�� K�� PT GKPT� S.Aur SV RVFK+ D S.Malt SVSRVF P.Aer SV RVF	-0.74	0.03	EXT
1160	V	(P.Aer) VSRVF (S.Malt) SVSRV S.Aur VSRV� FI+ S.Malt V RV�� FKFI	-1.10	0.15	EXT
1161	S	S.Aur SRVFK S.Malt SRVF KF P.Aer R FKF+D	-0.90	0.02	EXT
1162	R	S.Aur� RVFK+ D S.Malt R F KFID	-1.03	0.36	EXT
1163	V	S.Aur +FKF D and VF KF +M and VFK ID and� VF� IDM S.Malt V� FIDM P.Aer V� FIDM	-1.25	0.84	EXT
1164	F	S.Aur� FKF+++ and +KF++M S.Malt FKF+D P.Aer FKF�� ID	-1.13	0.65	EXT
1165	K	S.Aur and S.Malt KFID+ P.Aer KFI+M	-1.08	0.78	EXT
1166	F	F	-0.99	0.62	EXT
1167	I	I	-0.73	0.89	EXT
1168	D	D	-0.22	0.03	EXT
1169	M	M	0.42	0.95	EXT
1170	P	(BPI) PT GKPT P.Aer PTEGK and P EGKP S.Malt P EGKP S.Aur P E GKPT	0.79	0.14	EXT
1171	T	S.Aur TEGKP P.Aer TEGKP S.Malt TEGKP	1.31	0.14	EXT
1172	E	P.Aer� EGKPT S.Aur EGKPT S.Malt +GKPT	1.86	0.03	EXT
1173	G	(P.Aer) G PTKS	1.95	0.20	EXT
1174	K	K	2.19	0.40	EXT
1175	P	P	2.28	0.04	EXT
1176	T	T	2.28	0.06	EXT
1177	K	K	2.08	0.97	EXT
1178	S	S	1.85	0.06	EXT
1179	T	T	1.80	0.12	EXT
1180	K	K	1.78	0.64	EXT
1181	P	P	1.66	0.15	EXT
1182	Y		1.53	0.98	EXT
1183	K	K	1.17	0.35	EXT
1184	N	(P.Aer) NGQL	0.99	0.03	EXT
1185	G	G	0.74	0.07	EXT
1186	Q	Q	0.38	0.03	EXT
1187	L	L	0.03	0.60	EXT
1188	S	S	-0.56	0.06	EXT
1189	K	(gad65) KV�� M+I N�� H�� DI P.Aer KVM+I++ and K MIIE S.Malt KV IIE S.Aur KVMII	-1.03	0.55	EXT
1190	V	P.Aer VM IEN S.Malt V IIEN S.Aur +MIIEN	-1.05	0.73	EXT
1191	M	P.Aer MIIEN S.Malt M IIEN S.Aur M+IEN	-1.07	0.10	EXT
1192	I	(hspd1) IIE S�� V KD +�� DL� KY�� G�� +++� S.Aur IIENSH K and IIENS� KKD and I ENSHV S.Malt II NS� V KD P.Aer IIENS	-0.77	0.04	EXT
1193	I	I	-0.82	0.71	EXT
1194	E	P.Aer ENSHV	-0.91	0.03	EXT
1195	N	N	-0.60	0.05	EXT
1196	S	S	-0.17	0.03	EXT
1197	H	H	0.40	0.30	EXT
1198	V	(myelo) V K++I P.Aer VKKD+ S.Aur +KKDDI S.Malt VKKD++	0.90	0.95	EXT
1199	K	P.Aer and S.Aur KKDDIS.Malt KKDD+	0.73	0.95	EXT
1200	K	P.Aer KDDI	0.50	0.94	EXT
1201	D	D	0.51	0.08	EXT
1202	D	D	0.81	0.02	EXT
1203	I	I	1.26	0.08	EXT
1204	W	W	1.33	0.37	EXT
1205	P	P	1.36	0.03	EXT
1206	S	S	1.03	0.04	EXT
1207	G	S.Malt GG MTV�� T� YTEGG	0.86	0.04	EXT
1208	G	(hspd1) G� TVKD�� E�� LE I S.Malt GQMT+ D P.Aer� GQMT KD S.Aur GQMTV	0.81	0.04	EXT
1209	Q	P.Aer� QM VKD S.Aur +MTVK	0.98	0.08	EXT
1210	M	P.Aer MT+KD S.Malt MTVK	0.99	0.84	EXT
1211	T	T	0.47	0.04	EXT
1212	V	V	0.24	0.95	EXT
1213	K	(S.Aur) KDLT	0.04	0.67	EXT
1214	D	(hspd1) DL� KY�� G�� +++ P.Aer and S.Aur DLTAK S.Malt +LTAK	-0.01	0.03	EXT
1215	L	(P.Aer) LTA-YTEGG-A	0.09	0.49	EXT
1216	T	(rheum) TA� T GGN P.Aer TA YTEGG S.Malt T� YTE GN S.Aur TAKY and TA YT	0.20	0.03	EXT
1217	A	�P.Aer AKYTEG	0.56	0.82	EXT
1218	K	S.Aur KYTEG	0.74	0.79	EXT
1219	Y	�(mucin) Y +GG�� L NI F�� PG� V� L P.Aer YTE GN and YTEGG S.Aur YTE GN S.Malt� YT GGNA	0.83	0.98	EXT
1220	T	P.Aer� TEGGNA S.Aur� TEGGN S.Malt T GGNA	1.23	0.03	EXT
1221	E	P.Aer and S.Malt EGGNA S.Aur EG NA	1.10	0.03	EXT
1222	G	(P.Aer) GGNA L+ (hspd1) GG A L� I�� S� P�� Q +G� S.Aur GGNAI S.Malt GGNAI P.Aer GGNAI	0.89	0.09	EXT
1223	G	(BPI)� GN� L�� SIS�� G�� SGK T P.Aer GN� A LENIS S.Aur GN� ILE+IS S.Malt� GNA+LE	0.49	0.03	EXT
1224	N	S.Aur� N ILENIS P.Aer� NA LE IS S.Malt +AI� LENI	0.53	0.02	EXT
1225	A	P.Aer A LENIS S.Aur AIL� IS S.Malt� AI +NIS	0.45	0.07	EXT
1226	I	P.Aer� and S.Aur and S.Malt ILENI	-0.01	0.76	EXT
1227	L	P.Aer and S.Malt and S.Aur LENIS	-0.18	0.95	EXT
1228	E	E	-0.74	0.03	EXT
1229	N	(S.Aur)+NISF	-0.87	0.05	EXT
1230	I	I	-0.97	0.29	EXT
1231	S	S	-0.49	0.02	EXT
1232	F	(adren)F I SP P.Aer FSISP QR and FSI P QR+ S.Malt FSIS GQ�� RV S.Aur FSISP	-0.07	0.90	EXT
1233	S	(rheum) S SPG+R� L and S+SPGQ and� S+SPG+R� L� R�� S� L and S SPG+R S. S.Malt� SIS� PGQR S.Aur SISPG P.Aer S+ PGQRV and SISP QR	0.18	0.04	EXT
1234	I	S. Aur� I PGQRV S.Malt IS GQRV and I PGQRV S.Aur I PGQRV P.Aer I PGQRV	0.34	0.97	EXT
1235	S	(rheum) SPG+R P.Aer SPGQRV S.Aur SP +RV S.Malt SPGQR	0.68	0.03	EXT
1236	P	(rheum) PGQRV S.Malt and P.Aer PGQRV	0.47	0.03	EXT
1237	G	(P.Aer) GQRV-LL (S.Aur) G+ VGL G� G GK TL (S.Malt) GQRVGL P.Aer GQRV	0.76	0.19	EXT
1238	Q	(P.Aer) G-R+GLLG	0.40	0.09	EXT
1239	R	(P.Aer) R+GLLG	0.28	0.27	EXT
1240	V	(P.Aer) VGLLG	0.08	0.81	EXT
1241	G	S.Malt GLLGR	0.02	0.19	EXT
1242	L	IS GQRV	-0.05	0.97	EXT
1243	L	(P.Aer) and S.Malt LGRTG� S.Malt LG TGSGKST	-0.08	0.97	EXT
1244	G	S.Malt GR GSGKSTLL A�� LL	0.05	0.04	EXT
1245	R	(S.Aur) GR GSGK TLL	0.43	0.69	EXT
1246	T	(P.Aer) TGSGKSTL [TGSGKS] [TGSGK] S.MaltTGSGKST	0.65	0.11	EXT
1247	G	(P.Aer) GSGKSTLLS (S.Aur) GSGKSTL and GKSTLL and GSGKST and GSGKS (S.Malt) GSGKSTLL A	1.09	0.04	EXT
1248	S	(P.Aer) GSGKSTLL� and GSGK� LL (S.Aur) SGKST (S.Malt) QKLLN+R (BPI) SGK�� FL +	1.36	0.03	EXT
1249	G	(P.Aer) GKSTLL (S.Aur)� GKSTL (S.Malt) GKSTLL	1.05	0.43	EXT
1250	K	(P.Aer) GKST	0.67	0.49	EXT
1251	S	S	0.45	0.04	EXT
1252	T	S.Malt TLLSA LR S.Aur TLLSA P.Aer TLSSA	0.11	0.11	EXT
1253	L	(TNF) LLSA P.Aer and S.Aur and S.Malt�� LLSAF	-0.44	0.86	EXT
1254	L	L	-1.05	0.93	EXT
1255	S	S	-1.43	0.03	EXT
1256	A	A	-1.96	0.32	EXT
1257	F	F	-2.28	0.51	EXT
1258	L	(P.Aer) LRLL	-1.93	0.90	EXT
1259	R	(P.Aer) RLLN	-1.52	0.60	EXT
1260	L	(P.Aer) LLNT+G	-1.24	0.97	EXT
1261	L	(P.Aer) LNTE	-0.95	0.93	EXT
1262	N	N	-0.45	0.02	EXT
1263	T	(S.Aur) TEG+I+ (myelo)� T�� I I�� GVS�� +�� V P�� I�� FRK� D� +�� W ++ +��	-0.26	0.09	EXT
1264	E	(P.Aer) EGEI--DG (S.Aur) +G+IQID	-0.01	0.05	EXT
1265	G	G	0.18	0.25	EXT
1266	E	E	0.67	0.02	EXT
1267	I	(P.Aer) IQID	0.71	0.90	EXT
1268	Q	Q	0.56	0.02	EXT
1269	I	(P.Aer) (S.Aur) IDGV (P.Aer) I GVSWD	0.48	0.80	EXT
1270	D	D	0.15	0.04	EXT
1271	G	G	0.16	0.03	EXT
1272	V	(prot) V W� I� TL P.Aer VSWDS and V WDSI S.Malt VSWD I L S.Aur V W+� TLQQ	0.49	0.18	EXT
1273	S	P.Aer SW S TLQ S.Malt S DSI LQ and SWDS+ S.Aur SWD IT+	0.18	0.02	EXT
1274	W	(myelo) WD�� L Q+ RK� G�� Q +�� +�� T� RK L� Y�� D�� +A+� P.Aer WDSI�� QW S.Aur� WDSI LQ S.Malt WD�� L�� QQW S.Aur WDSI LQ	0.41	0.34	EXT
1275	D	P.Aer DSIT Q W S.Aur�� DS+�� LQQW S.Malt� +SITL Q R S.Aur DSI LQQ	-0.06	0.04	EXT
1276	S	P.Aer� S TLQ WR S.Aur S� L +WRK S.Malt� SI�� LQQWR	-0.06	0.04	EXT
1277	I	(P.Aer) ITL+QWR S.Aur +TLQ� RK S.Malt ITLQQ	0.04	0.09	EXT
1278	T	P.Aer TLQ WR S.Aur� TLQQ� K S.Malt TL QWR	-0.32	0.03	EXT
1279	L	S.Malt LQQWR (P.Aer) L QWRK S.Aur L +WRK	-0.06	0.97	EXT
1280	Q	Q	-0.21	0.63	EXT
1281	Q	Q	-0.35	0.18	EXT
1282	W	W	-0.36	0.68	EXT
1283	R	S.Malt RKAFGV+	-0.38	0.06	EXT
1284	K	K	-0.19	0.91	EXT
1285	A	A	-0.39	0.12	EXT
1286	F	(tnf) FGVI PQ (adren) FG�� I� K�� F G F�� E W�� ++� V�� +�� VI� P.Aer FGVIPQ S.Aur FGV+PQ S.Malt FGVIP	-0.40	0.16	EXT
1287	G	P.Aer GVIPQ S.Aur GV+PQ S.Malt� GVIP+	-0.07	0.03	EXT
1288	V	P.Aer SD+EIWK S.Aur�� VIPQ	-0.02	0.11	EXT
1289	I	(S.Aur) IPQK	-0.29	0.06	EXT
1290	P	P	-0.67	0.03	EXT
1291	Q	Q	-0.78	0.04	EXT
1292	K	K	-1.09	0.78	EXT
1293	V	V	-0.92	0.63	EXT
1294	F	F	-0.73	0.26	EXT
1295	I	I	-0.69	0.29	EXT
1296	F	F	-1.04	0.80	EXT
1297	S	S.Malt SGTFR N	-1.14	0.07	EXT
1298	G	G	-0.92	0.43	EXT
1299	T	T	-0.42	0.08	EXT
1300	F	F	-0.18	0.98	EXT
1301	R	R	0.38	0.10	EXT
1302	K	K	0.40	0.97	EXT
1303	N	(P.Aer) NLDP	0.43	0.05	EXT
1304	L	L	0.60	0.26	EXT
1305	D	D	0.94	0.03	EXT
1306	P	P	0.78	0.04	EXT
1307	Y	Y	0.98	0.92	EXT
1308	E	E	1.15	0.05	EXT
1309	Q	(tnf) QW +�� A+ V LR P.Aer Q SD+ +W VAD S.Aur +W S+� IW�� KVAD S.Malt Q SD� I WKVA+� EV	1.41	0.11	EXT
1310	W	P.Aer� WSDQ+�� VAD S.Aur W� D EI KV S.Malt WSDQ�� E�� +W�� KVA E+	1.32	0.87	EXT
1311	S	P.Aer� SD E WKVA S.Aur SDQE W and SDQEI S.Malt SD� EIWK	1.02	0.03	EXT
1312	D	(adren) D+++�� DEV P.Aer +QEI�� WKVA S.Aur� ++EIWK S.Malt DQ IW V	0.65	0.02	EXT
1313	Q	(hspd1) ++� KV� EV (P.Aer) +EIWK� S.Aur QE�� IWKV� ��DE S.Malt QE+ KV� EV	0.40	0.62	EXT
1314	E	P.Aer E+W V DEV S.Aur ++W +AD and EIW� ADE S.Malt EI KVA�� D V	0.17	0.03	EXT
1315	I	P.Aer +W VADE S.Aur IW VAD S.Malt IW VA++	0.33	0.36	EXT
1316	W	P.Aer W KVADE S.Aur� WK V DE S.Malt W�� VADE	0.32	0.82	EXT
1317	K	P.Aer KVADE S.Malt� KVAD+V	0.24	0.26	EXT
1318	V	(P.Aer) VADE+G S.Aur VADEV S.Malt� +ADEV	0.00	0.64	EXT
1319	A	A	-0.11	0.28	EXT
1320	D	D	-0.18	0.04	EXT
1321	E	E	0.11	0.02	EXT
1322	V	(P.Aer) VGLR	0.06	0.84	EXT
1323	G	(P.Aer) GLRS-IEQ	-0.01	0.03	EXT
1324	L	S.Malt LRSVI	-0.26	0.51	EXT
1325	R	R	-0.40	0.23	EXT
1326	S	S	-0.46	0.11	EXT
1327	V	(Calgr) VIE+�� LD and VIE+�� LD�� KQL�� M +AR�� S� K�� DE�� H P.Aer VIE F GKL and VIE +PGK S.Malt VIE FP K S.Aur VIEQ P	-0.45	0.29	EXT
1328	I	(S.Aur) IEQF� and IEQ P�� GKLD P.Aer I QFPG� D	-0.36	0.53	EXT
1329	E	(adren) E� PG� DFV	0.04	0.04	EXT
1330	Q	(P.Aer)� QFP-KLD-V-VD [QFPG]	0.25	0.04	EXT
1331	F	F	0.04	0.90	EXT
1332	P	P	0.26	0.02	EXT
1333	G	G	0.09	0.03	EXT
1334	K	(prot)� KLD VL P.Aer KLDFVL S.Aur KLDF L S.Malt� KLDF+L	-0.21	0.19	EXT
1335	L	P.Aer and S.Aur and S.Malt� LDFVL	-0.71	0.96	EXT
1336	D	D	-0.79	0.03	EXT
1337	F	S.Malt FVLVDG	-0.73	0.94	EXT
1338	V	(P.Aer) VLVDG	-0.77	0.15	EXT
1339	L	(P.Aer) LVDG	-0.90	0.75	EXT
1340	V	S.Malt VDGG VL HG	-0.73	0.74	EXT
1341	D	(P.Aer) DGGC	-1.00	0.14	EXT
1342	G	G	-1.00	0.43	EXT
1343	G	G	-0.69	0.03	EXT
1344	C	C	-0.33	0.03	EXT
1345	V	V	-0.05	0.21	EXT
1346	L	(P.Aer) LSHG+KQ	-0.19	0.98	EXT
1347	S	S	-0.21	0.20	EXT
1348	H	H	-0.31	0.06	EXT
1349	G	G	-0.62	0.03	EXT
1350	H	H	-0.75	0.04	EXT
1351	K	K	-0.60	0.41	EXT
1352	Q	(myelo) QL�� VLSK P.Aer QL�� M LA� VLS S.Malt� QL� LA SV SK S.Aur QLMC	-1.05	0.05	EXT
1353	L	P.Aer LMCLA S.Aur LM�� CLARS� S and� LMC+AR S.Malt� LMCL R and� LM L AR	-1.15	0.97	EXT
1354	M	P.Aer +CL RS+ S.Aur M LAR� LSK� SW.Malt M LA RS� SK	-1.30	0.66	EXT
1355	C	(P.Aer) CLAR and CL R�� SK S.Aur� CLAR VLS.Malt C+AR +L	-1.32	0.03	EXT
1356	L	(P.Aer) LARS S.Aur L RSVLS S.Malt LA� VLS	-1.57	0.89	EXT
1357	A	P.Aer ARS LSK S.Aut ARSV and AR VLS S.Malt AR VLS	-1.83	0.08	EXT
1358	R	P.Aer RS+LSK and RSVLS S.Aur� RS LSK S.Malt RSV SK	-1.40	0.06	EXT
1359	S	P.Aer SVLSK S.Malt SVLSK S.Aur SV+SK	-0.98	0.02	EXT
1360	V	V	-0.77	0.17	EXT
1361	L	S.Malt L� A ILLLDEP	-0.36	0.75	EXT
1362	S	S	-0.59	0.03	EXT
1363	K	K	-1.02	0.52	EXT
1364	A	A	-1.47	0.71	EXT
1365	K	(P.Aer) KILLLDEP (S.Aur)KILL DE� and� K+LLLDE	-1.64	0.93	EXT
1366	I	(S.Aur) IL LDEP A LDP T and IL LDEP A and ILLLDE (S.Malt) ILLLDE	-1.14	0.77	EXT
1367	L	(P.Aer) LLLDEP--HLD (P.Aer) LLLDEPS (P.Aer)+LLLDEP (S.Malt) +LLLDEP	-0.94	0.95	EXT
1368	L	(P.Aer) LLLDE [LLDE]	-0.81	0.90	EXT
1369	L	(P.Aer) LDEPSA (P.Aer)(S.Aur)LDEP (S.Malt) LDEPS HLD Smalt LDEPSA L P �(mucin) L++PS	-0.54	0.95	EXT
1370	D	(P.Aer) L LDEP� HLDP� YQ	-0.48	0.07	EXT
1371	E	E	-0.13	0.03	EXT
1372	P	P	0.16	0.03	EXT
1373	S	S	0.78	0.03	EXT
1374	A	A	1.19	0.76	EXT
1375	H	(P.Aer) HLDP	0.97	0.07	EXT
1376	L	L	0.89	0.97	EXT
1377	D	D	0.54	0.03	EXT
1378	P	P	0.29	0.03	EXT
1379	V	V	-0.08	0.24	EXT
1380	T	T	-0.38	0.02	EXT
1381	Y	Y	-0.27	0.97	EXT
1382	Q	(hspd1) +II RTLK S.Aur QIIRR�� Q�� QII� TL and +IIRR� and QIIR and QI� IR� +KQ and +II RT P.Aer +IIRR and QIIR and Q+ RRTL and Q� RRTL Q	-0.52	0.12	EXT
1383	I	S.Aur I RRTL and� IIRR and II R LK and II R LK and II�� RR LK and� II�� KQAF and IIRR L P.Aer IIRRTL	-0.57	0.97	EXT
1384	I	P.Aer� +RRTL� and IR� LKQA S.Malt IRR LKQ and� I R LKQA S.Aur IR�� TLK AF	-0.82	0.56	EXT
1385	R	�(gad65) RR L� KQ (P.Aer)� RR LKQ� and RRTL Q�� S.Aur� R TL QA S.Malt RR�� TLKQ and RRTL�� K AF and RR�� TLKQ	-0.91	0.85	EXT
1386	R	(hspd1)+II RTLK S.Aur� R TL QA and R�� KQAF P.Aer RTL QA and RRTL Q and� RTL� AF S.Malt� RTLK A	-0.75	0.44	EXT
1387	T	(myelo) TL Q F S.Malt� TL QAF D S.Aur TLK AF P.Aer TLKQAF and TLKQ F and TLK AF and TL� KQAF	-0.77	0.05	EXT
1388	L	L	-0.65	0.83	EXT
1389	K	(P.Aer) KQAF DC	-0.42	0.71	EXT
1390	Q	Q	-0.26	0.29	EXT
1391	A	A	-0.25	0.07	EXT
1392	F	F	-0.31	0.38	EXT
1393	A	A	-0.36	0.33	EXT
1394	D	D	-0.83	0.03	EXT
1395	C	C	-1.27	0.03	EXT
1396	T	T	-1.43	0.02	EXT
1397	V	V	-1.24	0.49	EXT
1398	I	I	-1.27	0.91	EXT
1399	L	L	-1.37	0.95	EXT
1400	C	C	-1.55	0.03	EXT
1401	E	E	-1.46	0.02	EXT
1402	H	(P.Aer) HRIE (S.Malt) +RIEA+L� QQ+	-1.29	0.05	EXT
1403	R	(P.Aer) R-EAML	-1.06	0.07	EXT
1404	I	I	-1.01	0.38	EXT
1405	E	E	-0.85	0.02	EXT
1406	A	A	-0.93	0.44	EXT
1407	M	M	-0.79	0.28	EXT
1408	L	(gad65) L+C�� LV EE P.Aer L CQ FL S.Aur LE CQQ S.Malt LECQQ	-0.87	0.93	EXT
1409	E	P.Aer ECQQ�� FL S.Aur EC+ FLV S.Malt ECQ FL	-0.97	0.02	EXT
1410	C	P.Aer CQQF V S.Aur C++ LV S.Malt� CQ+FL	-1.43	0.04	EXT
1411	Q	P.Aer QQFLV S.Aur QQFL+ S.Malt QQFL+	-1.57	0.03	EXT
1412	Q	P.Aer and S.Aur and S.Malt QFLV	-1.70	0.03	EXT
1413	F	F	-1.21	0.16	EXT
1414	L	L	-1.04	0.41	EXT
1415	V	(Adren) VI++N +R�� Y� I� LLN P.Aer VIEE KV S.Aur VI+ENKV� S.Malt VIE+NK	-0.82	0.22	EXT
1416	I	P.Aer +E NKVR S.Aur IE+NKV S.Malt IEENK	-0.77	0.62	EXT
1417	E	P.Aer EEN VR S.Aur EE K+RQ S.Malt EE KVR	-0.83	0.03	EXT
1418	E	P.Aer� EN +RQ S.Aur ENKV Q S.Malt EN KVRQ	-0.48	0.03	EXT
1419	N	P.Aer +KVRQ S.Aur NKVRQ S.Malt NKVR	0.01	0.08	EXT
1420	K	P.Aer and S.Aur and S.Malt� KVRQ	0.27	0.20	EXT
1421	V	V	0.73	0.70	EXT
1422	R	S.Malt RQYDS	0.71	0.58	EXT
1423	Q	Q	0.39	0.03	EXT
1424	Y	(prot) YD�� K LN+ P.Aer Y+ IQ�� KLL S.Aur Y+ I+KLLN S.Malt YD IQK	0.27	0.88	EXT
1425	D	P.Aer +S QKLL S.Aur DSI KLLN S.Malt D IQ LL+	0.13	0.03	EXT
1426	S	P.Aer SIQKL S.Aur SI+ LL S.Malt SIQ LL	-0.06	0.03	EXT
1427	I	P.Aer IQ LLN S.Aur IQKLL S.Malt IQ LL+	-0.38	0.17	EXT
1428	Q	P.Aer QKLL+ S.Aur +KLLN S.Malt QKLL+	-0.43	0.06	EXT
1429	K	P.Aer and S.Aur and S.Malt KLLN	-0.29	0.87	EXT
1430	L	L	-0.42	0.94	EXT
1431	L	(hspd1) LNER S.Aur and P.Aer and S.Malt LNERS	-0.49	0.92	EXT
1432	N	N	-0.66	0.05	EXT
1433	E	E	-0.99	0.03	EXT
1434	R	R	-0.97	0.64	EXT
1435	S	S	-0.65	0.03	EXT
1436	L	S.Malt LFRQA	-0.37	0.79	EXT
1437	F	S.Malt FRQAI	-0.49	0.76	EXT
1438	R	(myelo)� RQA�� IS S.Aur and S.Malt and P.Aer	-0.41	0.87	EXT
1439	Q	Q	-0.31	0.06	EXT
1440	A	A	-0.07	0.11	EXT
1441	I	I	0.56	0.78	EXT
1442	S	S	0.93	0.02	EXT
1443	P	P	0.80	0.16	EXT
1444	S	S	0.72	0.05	EXT
1445	D	D	0.48	0.11	EXT
1446	R	(BPI) RV L+�� PH N P.Aer RV LFP RN S.Aur R KLFP S.Malt RV KLFP	0.33	0.06	EXT
1447	V	P.Aer VKL PHR S.Aur VKLF H S.Malt VKLF	0.11	0.68	EXT
1448	K	P.Aer K FPHR S.Aur� KL+PH S.Malt KLF HRN	0.03	0.87	EXT
1449	L	P.Aer LF HRN S.Aur LFPH S.Malt LFPHR	-0.07	0.94	EXT
1450	F	P.Aerand S.Malt� FPHRN S.Aur FPHR	-0.22	0.92	EXT
1451	P	P.Aer and S.Aur and S.Malt PHRN	-0.12	0.03	EXT
1452	H	H	0.14	0.18	EXT
1453	R	R	0.27	0.93	EXT
1454	N	N	0.51	0.36	EXT
1455	S	S	0.81	0.06	EXT
1456	S	S	0.99	0.75	EXT
1457	K	K	1.16	0.96	EXT
1458	C	C	1.10	0.36	EXT
1459	K	(P.Aer) KSKPQIA	1.13	0.81	EXT
1460	S	S	0.89	0.03	EXT
1461	K	K	0.71	0.06	EXT
1462	P	P	0.56	0.03	EXT
1463	Q	Q	0.36	0.07	EXT
1464	I	(hspd1) IA LK +�� T EE+ S.Malt� I ALKEET E P.Aer I ALKEET S.Aur IA LKEE	0.39	0.31	EXT
1465	A	(S.Malt) AAL� E E� VQD� P.Aer AAL� ETEE S.Aur AAL EE� EE	0.37	0.23	EXT
1466	A	(P.Aer) ALKE� EEE S.Malt� ALKEE P.Aer� AL� ETEE S.Aur ALKEE	0.37	0.18	EXT
1467	L	S.Malt� L EE EE P.Aer L EETE S.Aur LK+ETE	0.46	0.98	EXT
1468	K	S.Malt KE+ EE P.Aer and S.Aur EETEE	0.52	0.95	EXT
1469	E	S.Malt and P.Aer and S.Aur EETE	0.80	0.12	EXT
1470	E	E	1.06	0.02	EXT
1471	T	T	1.10	0.03	EXT
1472	E	E	1.48	0.04	EXT
1473	E	(GAD65) EE++� RL S.Aur EEVQ+T P.Aer EE+�� +DTRL S.Malt EEVQD R	1.58	0.03	EXT
1474	E	(myelo) EV DT L S.Aur EVQ+TR P.Aer EV+�� DTRL S.Malt� EVQD TRL	1.51	0.05	EXT
1475	V	S.Aur VQ+TR P.Aer VQ� DTRL S.Malt VQ D RL	1.32	0.52	EXT
1476	Q	S.Aur QDTR and QD RL P.Aer QDTR+ S.Malt QD RL	0.84	0.05	EXT
1477	D	S.Aur and P.Aer and S.Malt DTRL	0.65	0.07	EXT
1478	T	T	0.50	0.23	EXT
1479	R	R	0.29	0.60	EXT
1480	L	L	0.41	0.96	EXT

Graphical illustrations of some of the matching consensus sequences between the CFTR protein (left to right) for S.Aureus (S.Aur), P.Aeruginosa (P.Aer) and autoantigens . The B or T cell epitope immunogenicity index is plotted on the Y axis along the length of the CFTR protein. Values of > 0.35 (B cell) or 0.5 (T cell) are the server set thresholds for epitope production. The matching consensus sequences are shown on the X- axis. The black bars show tripartite homologous overlapping regions (autoantigen/pathogen/CFTR) with a B cell epitope index of > 0.35 or a T cell index of > 0.5.

adren = adrenergic receptor ADRB2; bpi= bactericidal permeability-increasing protein; calgr = calgranulin; gad65 = glutamate decarboxylase 2; hspd1= heat shock protein 60; mucin = MUC1; myelo=myeloperoxidase; rheum = rheumatoid factor; tnf = tumour necrosis factor .
The consensus sequences are highlighted in white.

Fig 1,6 = amino acids 3- 298
Fig 2,7 = amino acids 299-511
Fig 3,8 = amino acids 537-722
Fig 4, 9 = amino acids 726-993
Fig 5,10 = amino acids 1010-1240

T cell immunogenicity index	B cell Immunogenicity index

BLAST results for the F508del and 19 CFTR point mutations (shown in red) vs. S.Aureus. P.Aeruginosa and S.Maltophilia: BLASTS vs. Bacteria and/or viruses are also linked.

Mutation

Alignments

Query=bacteria and viruses

F508Del ENIIFGVSY