Enhanced links are provided by Synechococcus phage is illustrated--------------->

BLAST results for various viruses using diverse Entrez filters as shown. (Translated viral genome vs. human proteins) Links to the BLAST are provided: The filter can be changed at will in the Entrez query section of the BLAST input page: For example "myelin", "multiple sclerosis" or "vitamin D" can be used for the viral BLASTS: For the autoantigen BLASTS, the species of virus targeted (or any other: e.g. bacteria) can also be changed. in the "Organism" field

Blast results for various myltiple sclerosis autoantigens and for EIF2B5 are also shown: Protein vs. protein. The species of virus (or bacteria or others) can be modified in the "organism" input in the "Choose search set section".

The BLAST paraneters are set to very low significance levels (E=-100000 ). This is because the BLAST algorithm is testing for identity between two entire proteins, and not for short intraprotein contiguous sequences. These can only be found by using such low p values and have to be identified by eye, scrolling down each results page.

The black streaks in these figures correspond to viral vatches within the human proteome.

 

Epstein-Barr (no filter)Many studies have implicated the Epstein-Barr virus in Multiple sclerosis

EIF2B causes vanishing white matter disease

BLAST

ATPBD4 SF1 NRARP SOCS7 PKD2 CDAN1 RASA4 IER3 ZC3H18 CEP135 CC2D1B SAV1 FAM8A1 KANK2 UNG COL18A1 GPR128 FAM120C QSOX2 PLEKHG4 PLEKHG5 EMID1 ANXA6 AKAP13 SPIB LAG3 DKK2 fertilin beta BRAP PLCE1 MUC5B TPRN PLEKHA7 VEGFA STXBP5L alpha-1,4-galactosyltransferase EXO3CL2 HK3 peripheral myelin protein 22 MCM3AP MTSS1 ABCA7 RAB3IP HLA-B associated transcript 3 PPP1R14B PLXNB3 NUDT14 bullous pemphigoid antigen KAZ TRIP6 MPEPL1 ZAP70 IRAK1 ATE1 MUC16 CIT DRPLA RAI1 GPR124 HTR3C calcium channel, voltage-dependent, L type, alpha 1D RRM2B SRRM3 RBM25 CCDC90A DOK7 DNAJC14 TSPAN3 ELN REEP1 BCL2L12 TTC19 INS-IGF2 SYNGR2 MSLN BRD4 MLLT1 MA HNRNPUL1 eukaryotic translation initiation factor 4 gamma 3 STAB2 SLC6A5 MTCH1 WIZ IQCK MEOX1 IMMT CRIPAK MED15 MAVS RGL3 GPRIN1 MHC class I antigen IGH@ ZCCHC24 TBC1D9 PCD10 RPGRIP1L EGLN2 CEACAM16 WNK2 PLEKHH1 RRM2 DDX31 RRM1 ADNP2 WNK1 TOM1 MUC2 MUC12 MON1B ZNF280B ZMYM3 PARVA CUX1 SPRR2D FBLN2 SMPDL3A ACACB TMEM132A GRM7 RASSF7 MAN1A1 XIRP1 ODF3B RGMB ABCB11 TWF1 HMX1 TSC2 C2CD3 CDKL5 PRDM16 CACNA1G LCN8 DYNC1LI2 LOC100129852 ZDHHC14 GAA PRNP COL4A3 TSL CHRNA4 IMPG1 PHYH RAB44 COL1A1 ryanodine receptor 3 ZNF318 DPH2 ZNF579 NCOA6 PPM1H PKN1 KDM4B CEBPA ROBO4 PTCHD2 FBXO17 IL1F10 SDK2 RCN2 OAZ1 ITGB2 ALDH1L1 MAPRE3 AATK ANKRD11 neuregulin 1 SCRIB CD80 PLCH2 MTFMT Epstein-Barr virus induced gene 3 OPN4 CCBE1 SRRM4 SRD5A1 ANKRD33B CAMK2B WDR67 ADRB1 LIPT2 CCDC12 PRICKLE1 MTRF1L RNASEK SGK2 POLA1 MARVELD3 TNFRSF25 SLC45A3 CCDC102A ALDH3A1 ST8SIA3 POLD1 HSCB PNLDC1 TRIM26 CASKIN1 SLC39A7 MUC5AC PRRT4 LINGO1 UBE4B VEGFR1 REV3L TTYH1 UPS42 NLGN2 RAPGEF1 PIDXL RGH14 CTAGE5 ADAM33 SYNJ1 EFR3B RAMP3 SLC4A11 MTX1 GREB1L immunoglobulin kappa light chain variable region ERN2 IL10 UBR5 MARCH9 PLXNA4 FOXC2 IDUA PSMB11 TCP10L2 NXPH4 PRX BSCL2 ZNF173 ATXN2 PFAS TGFA PIF1 schwannomin interacting protein 1 C2CD4D TUBB8 FOXK1 SSH1 sodium channel nonvoltage-gated 1 delta AFAM2 TCEB3B ZNF716 SLC25A48 PRKCA TCP10 cytochrome oxidase subunit II SHANK1 TPBG AHCYL2 LTC4S PLEKHA4

Filter =multiple sclerosis

BLAST

IFNAR1 CBLB PARD3B NFASC POU2AF1 MBP CD97 CLDN11 MATN3 MMP28 RNF19A RAD54B C6orf27 LAMB2 HTATIP2 TRIM15 TNFSF12 XRCC1 T cell receptor alpha RPL19 CD2 OPTN eIF2B4 OGG1 PDE4B HS3ST2 IL22RA1 LEKR1 DARS2 DCLRE1C KCNB2 TMEM39A SMUG1 CD247 BRCA2 IRF5 BUD13 PDZRN4 ECE2 CACNG4 SLC44A4 NUDT4 KLC1 IL16 CEP170 CENPC1 PREP CD2AP NHEJ1 HLA-DRB5 ERCC1 GFI1 CYFIP2 EVI5 EN1 PKN1 PLCE1 ZP4 HLA-DRA CIITA MMP25 MMP9 RAD51 KCNJ7 C4A GABBR1 LIG3 MX1L XRCC2 TKT IL7R CNP FMN2 GRN PAM LMNB1 HAVCR2 ZIC1 WDR64 RPA1 PCSK5 IGH@ SHROOM3 ADNP RAD23A OLIG1 HDAC11 ALS2 NBN ICAM3 RAD54L FH CBLN2 TLR3 EPC1 WDR7 MNAT1 NRLP11 SH2B3 CD58 FEN1 GBP1 SNPH KIF1A MUTYH KLRB1 RFC1 RAD51L3 XRCC3 CNTF SPG11 SLC25A36 POLG CYP27B1 MPG VPS54 VAV2 OAS3 CCNH NTHL1 PTPRZ1 CYP24A1 CLEC16A T-cell receptor beta APEX2 RAD51C ADAMTSL1 HELZ NEIL2 BDNF MYO9B METTL1 MUS81 SPARCL1 CHRND FLNA C4orf33 BICD1 KIF21B CYP4V2 IRF9 KANK1 LILRA3 BANK1 PGGT1B HSPB2 MPHOSPH9 TRD@ POLE WT1 LINGO1 ENTPD1 RGNEF POLD1 OLIG3 ADAMTS14 CASP8 JARID2 SH2D2A XAB2 EME1 OPN3 NDUFS5 CTGF POL3RC CNTN2 SCHIP1 USP31 SLC25A27 DCP1A H6PD GDF5 GPC5 HCRT IFNGR2 XRCC4 PARP2 PRKDC PSMD2 ERCC8 NCKAP5 PDMB9 RAD52 TSC2 C1orf125 BSV CD6 FURIN ADAD1 ALK CD200R1 ERCC3 SMAD7 ERVWE1 SYN3 MMS19 IFIH1 ASAP1 MERTK RGMA

Synechococcus phage no filter Multiple sclerosis genes and relevant proteins are in blue Autoantigens in green

BLAST
ABCA4 ADAMTS12 AEBP1 AGPAT9 AHDC1 ALDH8A1 AMICA1 ANP32E ATRN BAI2 C1orf94 C20orf72 CATSPER1 CCDC46 CCDC146 CCNK CD1B CD2AP CELSR3 CENPI CLCN6 CPN2 CROT CRYAA CSPG4 CTNNBL1CYP2R1 CYP4V2 DCAF13 DERL2 DGKB DHX36 DMRTB1 DNAJC14 DNAJC16 DOLPP1 DYM EP400 ESPN FAM38B FAM72D FBXO38 FIBP FIP1L1 FKBP9FOLH1 FOXO3 FOXP1 G6PD GP1BA GPR85 GPR98 GRHPR GTPBP6HAO2 HEATR5B HEATR7B2 HLA-DQB1 HLA-DRB1 H6PD HSF2BP HSP90AA1 IGH@ INPP5D JAKMIP3 KIAA1826 KIF2A KIF18A KIF23 KIR3DL2 KLKB1 KRT13 LAMA1 LINGO2 LOC285074 LOC401097 LOC727787 LOC100288144 LOC100293516 LOC100508689 MACF1 MAFG MAG MAPKBP1 MAP4K2 MAPK9 MAPK10 MBP MCM6 MDN1 MEGF11MGAT5B MLL MLXIP MMP21 MOG MPP5 MTMR7 MTRNR2L3 MTMR7 MUC2 MUC16 myelin transcription factor 1 myelin transcription factor 1-like proteinMYO18A NCL NFASC NOX1 NRIP1 OBSCN OR5M9 OR5K3 OR5K4 OR14L1P OXCT1PAPPA2 PFKFB1 PGAP1 PHRF1PGD PKD1POLD1 PSMC3 PTPN14 RFC1 RFC3 RFC5 RMND5A ROBO1 RSPH10B2 RREB1 RRM1 RSAD2 RXFP3 SAMD1 SCN7A SERPINI2SF3A1SGCZ SLC2A8 SLC35E3 SLC38A11SMC1BSPATA5 SRGAP2P2 STRC SYNE1 SYNM TAF1 TAF9 TALDO1TAOK2 TDRD3 TEAD3 TFE3 DAPK1 TMEM88B TMEM117 TMEM168 TNIK TRA@ TRB@ TRD@ TTN TLL1TULP1 UBA2 UBE2J1 VWCE WDR81XKR3 XKRX YRDCZNF587 ZNF770 LOC100509054 ANKRD12 IFI44 FAM72A PRRT1 SARNP GOLGB1 AGPAT9 SYN2 POLA1 TRIM34 MAP4K2PEX1 CLCN6 SLC22A8 MGAT4A FLJ22184 RORB MBTPS2 NCKAP1 NIPBL RFC2 TSPAN12 SLC6A9 RSPH10B NEXN CDH12 SSH1 PCNXL2 SMC1A OR5M9 FMOD FAM72D KRTAP19-3 WDHD1 NPSR1 RFXP3 ZNF148 MAGEC1 SLC44A4 MYO15A ABCG2 UHRF1BP1 CPEB4 TMEM41B FMN1 TMEM202 EIF3M SMC4

Synechococcus Phage Filter = Multiple sclerosis

BLAST (filter has to be applied)

 GABBR1 CNLB OAS3 TLR7 ASAP1 C1orf125 CIITA EPC1 OLIG3 GAPDH HTATIP2 C20orf46 OR2H1 USP31 POLB MYO9B TSC1 EIF2B2 TKT WDR7 CASP10 POLD1 KCNK5 HDAC11 NOD1 MBD4 LEKR1 PGGT1B OAS1 RAD23A GDF5 IL16 DBP FAM69A MGAT5 KIF1A MXI1 EVI5 BSN H6PD ADNP HAPLN1 XRCC5 ASPN POLE RFC5 PDE8A IDS KIF21B CKB KCNB2 JARID2 XAB2 NIPA1 IL22RA1 CD2AP OPTN MNAT1 WRN S1PR3 PDLIM7 PLKCE1 POLG RGS7 NCKAP1 RAD54B NCKAP5 PTPRC C4A ERCC3 APEX2 IL21R EIF2B3 RAD54L HLA-DRA ASAP2 VAV2 SNPH ZIC1 ICAM3 ZNF433 PVRL2 CD40 BANK1 VPS54 RFC2 DDX58 PON2 XRCC6 HLA-G HELZ NLRP11 GBP1 CYFIP2 TRIM26 IFNAR1 RPA1 CYP27B1 KCNH7 MMP28 PLD5 ADFAMTSL1 IFT74 CNTF DCP1A CD97 MX2 MRE11A S1PR1 CDK7 CPAMD8 TNFRSF19 CEP170 ADAMTS14 TLR8 PNPT1 FLAD1 ADAD1 PDZRN4 FLNA MPHOPH9 CYP4D2 MUS81 CCDC46 ENTPD1 CD226 PMN2 TALDO1 LINGO1 RNF19A KIF1B LANB2 SLC44A4 RGNEF RAD23B SMUG1 KCNIP1 NFASC HLA-DRB1 BUD13 ST8SIA1 EMR2 PARP2 WDR64 CCL14 PTPRZ1 CLEC16A TSC2 TAC4 RFC4 RAD21L1 KANK1 ZNF45 TLR10 EME1 NFKBIL1 PARD3B SLC25A27 PSMD2 PVALB CLDN11 ERVWE1 PNKP CHRND CD200R1 PRKDC LIG4 HAVCR2 CDC42 KIF5A PADI2 ALS2 DCLRE1C ADARB1 KCNA5 CYP2R1 PREP MMP8 SPG11 MMS19
Autoantigens Red viruses in all cases have been implicated as risk factors or disease modifying agents in MS or in demyelination; These are linked to Pubmed: Autoantibodies identified by microarray

Crystallin CRYAB

BLAST

 

CNP NP_149124:2',3'-cyclic-nucleotide 3'-phosphodiesterase

 

BLAST
Murid herpesvirus 4 Autographa californica nucleopolyhedrovirus Feline immunodeficiency virus Klebsiella phage Butterbur mosaic virus Human herpesvirus 6B Influenza A virus Bacillus thuringiensis phage Acanthamoeba polyphaga mimivirus Human parainfluenza virus Ectocarpus siliculosus virus African swine fever virus Canine calicivirus Bovine papular stomatitis virus Gallid herpesvirus 3 Human coxsackievirus Lassa virus Ostreococcus tauri virus Pseudoalteromonas phage Duck hepatitis A virus Shallot virus Mopeia virus Porcine teschovirus Human astrovirus Clostridium phage Prochlorococcus phage Anticarsia gemmatalis nucleopolyhedrovirus] >gb|ABI13886.1| polynucleotide kinase/ligase [Anticarsia gemmatalis nucleopolyhedrovirus Gossypium darwinii symptomless alphasatellite Epizootic haematopoietic necrosis virus Equid herpesvirus 1 Verbena latent virus Human herpesvirus 6] Human parechovirus Microplitis demolitor bracovirus Cyanophage PSS2 Agrotis segetum granulovirus [Ovine adenovirus Canine papillomavirus Heliothis virescens ascovirus Tree shrew adenovirus Hyperthermophilic Archaeal Virus Mopeia Lassa reassortant 29 Lymphocytic choriomeningitis virus Avian paramyxovirus Tomato yellow leaf curl Sardinia virus Mycobacterium phage Infectious bronchitis virus Hepatitis delta virus Blackberry virus Y Pseudomonas phage Acidianus two-tailed virus Human herpesvirus 3 oa semilatent virus JC polyomavirus Meleagrid herpesvirus Pseudocowpox virus Helleborus net necrosis virus Streptomyces phage Canine distemper virus Acinetobacter phage bovine viral diarrhea virus Bathycoccus sp Rachiplusia ou MNPV Human respiratory syncytial virus Grapevine fleck virus Burkholderia ambifaria phage Paramecium bursaria Chlorella virus Watermelon mosaic virus Avian hepatitis E virus Peste-des-petits-ruminants virus Tiger frog virus Influenza B virus Human enterovirus Nanovirus-like particle Equine encephalosis virus Bovine polyomavirus Leucania separata nuclear polyhedrosis virus Ambystoma tigrinum virus Chinese wheat mosaic virus Rice tungro spherical virus Emiliania huxleyi virus Soft-shelled turtle iridovirus Goatpox virus Hepatitis B virus Toscana virus Cowpox Bear Canyon virus Feline calicivirus Burkholderia phage Human herpesvirus 2 Semliki forest virus Trichoplusia ni ascovirus Human adenovirus Human herpesvirus 5 BK polyomavirus Barley stripe mosaic virus VP8 [Micromonas pusilla reovirus] >gb|AAZ94048.1| VP8 [Micromonas pusilla reovirus] Eyach virus Shigella phage Nicotiana velutina mosaic virus Gallid herpesvirus 1 Venezuelan equine encephalitis virus Cymbidium mosaic virus Peanut clump virus Porcine rubulavirus] Human rhinovirus Soybean mosaic virus Ectromelia virus Asian prunus virus Cherry green ring mottle virus Phaius virus Escherichia phage Narcissus symptomless viru Human immunodeficiency virus 1 Kalanchoe latent virus Ralstonia phage Beet necrotic yellow vein virus Buggy Creek virus Horseradish latent virus Human parvovirus Wheat yellow dwarf virus-RPV Lactobacillus phage Bovine parainfluenza virus Bovine leukemia virus Liao ning virus Human echovirus Simian picornavirus Bacillus phage Bovine herpesvirus 5 Canine coronavirus Synechococcus phage Maize chlorotic dwarf virus Bovine enterovirus Clover yellow mosaic virus Human bocavirus Kashmir bee virus Wood mouse herpesvirus Zygocactus virus Hepatitis C virus Human herpesvirus 4 Potato virus Alcelaphine herpesvirus 1 Grapevine rupestris stem pitting-associated virus Rhodothermus phage Staphylococcus phage Equid herpesvirus 4 Abalone herpesvirus Beet soil-borne mosaic virus Grapevine fanleaf virus Morogoro virus Turkey coronavirus Murid herpesvirus 2 Vibrio phage Edge Hill virus Spinach severe curly top virus Aeromonas phage Borna disease virus Garlic virus Streptococcus phage

Myelin oligodendrocyte protein No filter

 

BLAST

none

Nemesia ring necrosis virus Feline infectious peritonitis virus (cat ownership linked with MS) Seoul virus Lumpy skin disease virus Spodoptera litura NPV Nyamanini virus Grapevine chrome mosaic virus Human herpesvirus 4 Hepatitis delta Beet western yellows Bacillus phage Turnip mosaic virus Streptococcus pyogenes phage Heliothis armigera cypovirus Emiliania huxleyi virus Bovine enteric calicivirus Clostridium phage Cypovirus Acanthamoeba polyphaga mimivirus Citrus tristeza virus Border disease virus Epstein-BarrMurine hepatitis virus Marseillevirus Merino Walk virus shrimp white spot syndrome virus coxsackievirus Human immunodeficiency virus Yokose virus Human astrovirus Avian orthoreovirus Mycobacterium phage influenza a Mokola virus poliovirus Phocoena spinipinnis papillomavirus Bombyx mandarina nucleopolyhedrovirus Watermelon mosaic virus Gallid herpesvirus 2 Temperate phage Mumps virus Louping ill virus

Myelin associated glycoprotein

No filter MS implicated or demyelinating viruses are in red

BLAST

 MAGVPnoneEnterobacteria phage Mamestra configurata Corynebacterium phage Lily virus X Psittacid herpesvirus Adult diarrheal rotavirus Yersinia phage Mycobacterium phage Vibrio phage Influenza A virus Papillomavirus Euproctis pseudoconspersa nucleopolyhedrovirus Pseudomonas phage Streptococcus phage Actinomyces phage Pelargonium zonate spot virus Lactococcus phage Molluscum contagiosum virus Marseillevirus Bacillus phage Burkholderia phage Human herpesvirus 5 Allium virus Musca domestica salivary gland hypertrophy virus Epstein-Barr Colorado tick fever virus Staphylococcus phage Ralstonia phage
Myelin Basic protein Theiler's encephalomyelitis virus Epstein-Barr Bean yellow disorder virus Rotavirus A Influenza A Citrus tristeza virus Measles virus Yersinia phage Lactococcus phage Rabbit hemorrhagic disease virus Enterobacteria phage Broome virus Campylobacter phage Human herpesvirus 3 Human herpesvirus 2 Listeria phage Human adenovirus 4 Human herpesvirus 7 Hepatitis delta Polyoma virus Human T-lymphotropic virus Newcastle disease virus Sapovirus Pepino mosaic virus Hepatitis C Torque teno virus sea trout rhabdovirus Banna virus Rubella virus Marseillevirus Hepatitis B Rice stripe virus Human parvovirus Norovirus Bacillus phage Felid herpesvirus 1 (cat ownership)

EIF2B5 Not demonstrated as an autoantigen, but homologous with Epstein-Barr

BLAST

 Enterococcus phage Ateline herpesvirus 3 Mouse parvovirus Canine papillomavirus (Dog ownership) Human herpesvirus 8 Yersinia phage Human herpesvirus 5 Latino virus Bacillus thuringiensis phage Murid herpesvirus 2 Oryza rufipogon endornavirus Canarypox virus Bean common mosaic necrosis virus Haemophilus phage Actinoplanes phage Equid herpesvirus 4 Mycobacterium phage Human adenovirus Streptococcus phage Human herpesvirus 1 Human enterovirus Corynebacterium phage Ralstonia phage Alfalfa mosaic virus Burkholderia phage Rubella virus Bacillus phage Helicoverpa armigera NPV Hepatitis C Enterobacteria phage Klebsiella phage Equine rhinitis B virus Escherichia phage Acidianus two-tailed virus Tupaiid herpesvirus Cyprinid herpesvirus 3 Norwalk virus Hyperthermophilic Archaeal Virus Lymphocystis disease virus Human metapneumovirus Spinach latent virus Camelpox virus Saimiriine herpesvirus 2 Listeria phage Trichoplusia ni SNPV Ostreococcus virus Poliovirus SARS coronavirus Soybean chlorotic mottle virus Staphylococcus phage Choristoneura occidentalis granulovirus Streptomyces phage Porcine adenovirus Shigella phage Ostreococcus tauri virus 1 Marseillevirus Vibrio phage Japanese encephalitis virus] Agrotis ipsilon multiple nucleopolyhedrovirus Ictalurid herpesvirus 1 Mumps virus Cowpox virus [Botrytis cinerea debilitation-related virus Variola virus Lactobacillus phage Suid herpesvirus 1 Human herpesvirus 4 Shrimp white spot syndrome virus Plutella xylostella granulovirus Lactococcus phage Felid herpesvirus 1 Clanis bilineata nucleopolyhedrosis virus Acanthamoeba polyphaga mimivirus West Nile virus Glossina pallidipes salivary gland hypertrophy virus Human herpesvirus 6 Measles virus Rachiplusia ou MNPV Ectocarpus siliculosus virus 1 Musca domestica salivary gland hypertrophy virus Clostridium phage Human herpesvirus 3 Human papillomavirus Human herpesvirus 7 St. Louis encephalitis virus Human coronavirus Taterapox virus Epstein-Barr Equid herpesvirus 9 Citrus psorosis virus Haloarcula phage

 

 

 

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