Search PATHWAY

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (46)

cpd:C00735 Cortisol cpd:C00780 Serotonin cpd:C02017 Corticotropin cpd:C13662 Arg-vasopressin cpd:C15901 Galanin cpd:C16079 Corticotropin releasing hormone cpd:C16088 Pituitary adenylate cyclase-activating peptide-38 hsa:117 ADCYAP1R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I hsa:150 ADRA2A; adrenergic, alpha-2A-, receptor hsa:152 ADRA2C; adrenergic, alpha-2C-, receptor hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:553 AVPR1B; arginine vasopressin receptor 1B hsa:886 CCKAR; cholecystokinin A receptor hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal) hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal) hsa:1268 CNR1; cannabinoid receptor 1 (brain) hsa:1394 CRHR1; corticotropin releasing hormone receptor 1 hsa:1395 CRHR2; corticotropin releasing hormone receptor 2 hsa:1812 DRD1; dopamine receptor D1 hsa:1813 DRD2; dopamine receptor D2 hsa:1814 DRD3; dopamine receptor D3 hsa:1815 DRD4; dopamine receptor D4 hsa:2556 GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 hsa:2558 GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2563 GABRD; gamma-aminobutyric acid (GABA) A receptor, delta hsa:9248 GPR50; G protein-coupled receptor 50 hsa:2899 GRIK3; glutamate receptor, ionotropic, kainate 3 hsa:2900 GRIK4; glutamate receptor, ionotropic, kainate 4 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2913 GRM3; glutamate receptor, metabotropic 3 hsa:2917 GRM7; glutamate receptor, metabotropic 7 hsa:2918 GRM8; glutamate receptor, metabotropic 8 hsa:3350 HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled hsa:3351 HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled hsa:3952 LEP; leptin hsa:4157 MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) hsa:2908 NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) hsa:4988 OPRM1; opioid receptor, mu 1 hsa:5021 OXTR; oxytocin receptor hsa:5027 P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7 hsa:56288 PARD3; par-3 partitioning defective 3 homolog (C. elegans) hsa:319100 TAAR6; trace amine associated receptor 6

hsa01100 Metabolic pathways - Homo sapiens (human) (45)

cpd:C00018 Pyridoxal phosphate cpd:C00019 S-Adenosyl-L-methionine cpd:C00051 Glutathione cpd:C00078 L-Tryptophan cpd:C00155 L-Homocysteine cpd:C00328 L-Kynurenine cpd:C00338 Lipopolysaccharide cpd:C00504 Folate cpd:C00735 Cortisol cpd:C00780 Serotonin cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid cpd:C01780 Aldosterone cpd:C05443 Vitamin D3 hsa:15 AANAT; aralkylamine N-acetyltransferase (EC:2.3.1.87) hsa:100 ADA; adenosine deaminase (EC:3.5.4.4) hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:271 AMPD2; adenosine monophosphate deaminase 2 (EC:3.5.4.6) hsa:438 ASMT; acetylserotonin O-methyltransferase (EC:2.1.1.4) hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:56267 CCBL2; cysteine conjugate-beta lyase 2 (EC:2.6.1.7 4.4.1.13 2.6.1.63) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1543 CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1559 CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:160851 DGKH; diacylglycerol kinase, eta (EC:2.7.1.107) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15) hsa:2731 GLDC; glycine dehydrogenase (decarboxylating) (EC:1.4.4.2) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146) hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5428 POLG; polymerase (DNA directed), gamma (EC:2.7.7.7) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6303 SAT1; spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) hsa:7166 TPH1; tryptophan hydroxylase 1 (EC:1.14.16.4) hsa:121278 TPH2; tryptophan hydroxylase 2 (EC:1.14.16.4)

hsa04726 Serotonergic synapse - Homo sapiens (human) (24)

cpd:C00078 L-Tryptophan cpd:C00780 Serotonin hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:1559 CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:3350 HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled hsa:3351 HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled hsa:3359 HTR3A; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic hsa:9177 HTR3B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6532 SLC6A4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 hsa:7166 TPH1; tryptophan hydroxylase 1 (EC:1.14.16.4) hsa:121278 TPH2; tryptophan hydroxylase 2 (EC:1.14.16.4)

hsa04728 Dopaminergic synapse - Homo sapiens (human) (20)

hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1812 DRD1; dopamine receptor D1 hsa:1813 DRD2; dopamine receptor D2 hsa:1814 DRD3; dopamine receptor D3 hsa:1815 DRD4; dopamine receptor D4 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2774 GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa04020 Calcium signaling pathway - Homo sapiens (human) (20)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:553 AVPR1B; arginine vasopressin receptor 1B hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:886 CCKAR; cholecystokinin A receptor hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal) hsa:1812 DRD1; dopamine receptor D1 hsa:2774 GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5021 OXTR; oxytocin receptor hsa:5027 P2RX7; purinergic receptor P2X, ligand-gated ion channel, 7 hsa:5136 PDE1A; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa00380 Tryptophan metabolism - Homo sapiens (human) (17)

cpd:C00078 L-Tryptophan cpd:C00328 L-Kynurenine cpd:C00780 Serotonin cpd:C01717 4-Hydroxy-2-quinolinecarboxylic acid hsa:15 AANAT; aralkylamine N-acetyltransferase (EC:2.3.1.87) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:438 ASMT; acetylserotonin O-methyltransferase (EC:2.1.1.4) hsa:56267 CCBL2; cysteine conjugate-beta lyase 2 (EC:2.6.1.7 4.4.1.13 2.6.1.63) hsa:1543 CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:7166 TPH1; tryptophan hydroxylase 1 (EC:1.14.16.4) hsa:121278 TPH2; tryptophan hydroxylase 2 (EC:1.14.16.4)

hsa05034 Alcoholism - Homo sapiens (human) (16)

hsa:627 BDNF; brain-derived neurotrophic factor hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1392 CRH; corticotropin releasing hormone hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1812 DRD1; dopamine receptor D1 hsa:1813 DRD2; dopamine receptor D2 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:4852 NPY; neuropeptide Y hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4 hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa04724 Glutamatergic synapse - Homo sapiens (human) (15)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2899 GRIK3; glutamate receptor, ionotropic, kainate 3 hsa:2900 GRIK4; glutamate receptor, ionotropic, kainate 4 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2913 GRM3; glutamate receptor, metabotropic 3 hsa:2917 GRM7; glutamate receptor, metabotropic 7 hsa:2918 GRM8; glutamate receptor, metabotropic 8 hsa:9456 HOMER1; homer homolog 1 (Drosophila) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) (14)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:1268 CNR1; cannabinoid receptor 1 (brain) hsa:2166 FAAH; fatty acid amide hydrolase (EC:3.5.1.99) hsa:2556 GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 hsa:2558 GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2563 GABRD; gamma-aminobutyric acid (GABA) A receptor, delta hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa05032 Morphine addiction - Homo sapiens (human) (14)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:1812 DRD1; dopamine receptor D1 hsa:2556 GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 hsa:2558 GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2563 GABRD; gamma-aminobutyric acid (GABA) A receptor, delta hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:4988 OPRM1; opioid receptor, mu 1 hsa:50940 PDE11A; phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17) hsa:5136 PDE1A; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (14)

cpd:C00533 Nitric oxide hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex) hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2774 GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa04727 GABAergic synapse - Homo sapiens (human) (13)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:2556 GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 hsa:2558 GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2563 GABRD; gamma-aminobutyric acid (GABA) A receptor, delta hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15) hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04725 Cholinergic synapse - Homo sapiens (human) (13)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6) hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal) hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:60482 SLC5A7; solute carrier family 5 (choline transporter), member 7

hsa05200 Pathways in cancer - Homo sapiens (human) (13)

cpd:C00735 Cortisol hsa:367 AR; androgen receptor hsa:1950 EGF; epidermal growth factor hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04540 Gap junction - Homo sapiens (human) (12)

cpd:C00533 Nitric oxide cpd:C00780 Serotonin hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:1812 DRD1; dopamine receptor D1 hsa:1813 DRD2; dopamine receptor D2 hsa:1950 EGF; epidermal growth factor hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:3356 HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled hsa:3358 HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa05031 Amphetamine addiction - Homo sapiens (human) (12)

hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1812 DRD1; dopamine receptor D1 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:23411 SIRT1; sirtuin 1 hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa04010 MAPK signaling pathway - Homo sapiens (human) (12)

cpd:C00338 Lipopolysaccharide hsa:627 BDNF; brain-derived neurotrophic factor hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:1950 EGF; epidermal growth factor hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:3553 IL1B; interleukin 1, beta hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (12)

hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:1950 EGF; epidermal growth factor hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3952 LEP; leptin hsa:4804 NGFR; nerve growth factor receptor hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05030 Cocaine addiction - Homo sapiens (human) (12)

hsa:627 BDNF; brain-derived neurotrophic factor hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:1812 DRD1; dopamine receptor D1 hsa:1813 DRD2; dopamine receptor D2 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2913 GRM3; glutamate receptor, metabotropic 3 hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa05143 African trypanosomiasis - Homo sapiens (human) (11)

cpd:C00078 L-Tryptophan cpd:C00328 L-Kynurenine cpd:C00533 Nitric oxide hsa:3620 IDO1; indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:7124 TNF; tumor necrosis factor

hsa05152 Tuberculosis - Homo sapiens (human) (11)

cpd:C00338 Lipopolysaccharide hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa05146 Amoebiasis - Homo sapiens (human) (11)

cpd:C00533 Nitric oxide hsa:2774 GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa05166 HTLV-I infection - Homo sapiens (human) (10)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:894 CCND2; cyclin D2 hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7494 XBP1; X-box binding protein 1

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (10)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:56288 PARD3; par-3 partitioning defective 3 homolog (C. elegans) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4 hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor)

hsa05140 Leishmaniasis - Homo sapiens (human) (10)

cpd:C00533 Nitric oxide hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (10)

cpd:C13662 Arg-vasopressin hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:185 AGTR1; angiotensin II receptor, type 1 hsa:553 AVPR1B; arginine vasopressin receptor 1B hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5583 PRKCH; protein kinase C, eta (EC:2.7.11.13)

hsa05144 Malaria - Homo sapiens (human) (9)

cpd:C00533 Nitric oxide hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa05168 Herpes simplex infection - Homo sapiens (human) (9)

hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48) hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:8864 PER2; period homolog 2 (Drosophila) hsa:8863 PER3; period homolog 3 (Drosophila) hsa:7124 TNF; tumor necrosis factor

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (9)

cpd:C05443 Vitamin D3 hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05010 Alzheimer's disease - Homo sapiens (human) (9)

cpd:C00533 Nitric oxide hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:348 APOE; apolipoprotein E hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3553 IL1B; interleukin 1, beta hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:7124 TNF; tumor necrosis factor

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (8)

cpd:C00019 S-Adenosyl-L-methionine cpd:C00533 Nitric oxide hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:6303 SAT1; spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57)

hsa05145 Toxoplasmosis - Homo sapiens (human) (8)

hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa04710 Circadian rhythm - mammal - Homo sapiens (human) (8)

hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48) hsa:1407 CRY1; cryptochrome 1 (photolyase-like) hsa:1408 CRY2; cryptochrome 2 (photolyase-like) hsa:4862 NPAS2; neuronal PAS domain protein 2 hsa:8864 PER2; period homolog 2 (Drosophila) hsa:8863 PER3; period homolog 3 (Drosophila) hsa:6095 RORA; RAR-related orphan receptor A TIMELESS belongs here

hsa04730 Long-term depression - Homo sapiens (human) (8)

cpd:C00533 Nitric oxide hsa:1392 CRH; corticotropin releasing hormone hsa:1394 CRHR1; corticotropin releasing hormone receptor 1 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04916 Melanogenesis - Homo sapiens (human) (8)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:4157 MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04976 Bile secretion - Homo sapiens (human) (7)

cpd:C00051 Glutathione cpd:C00504 Folate cpd:C00735 Cortisol cpd:C00780 Serotonin hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1)

hsa05033 Nicotine addiction - Homo sapiens (human) (7)

hsa:1137 CHRNA4; cholinergic receptor, nicotinic, alpha 4 (neuronal) hsa:1139 CHRNA7; cholinergic receptor, nicotinic, alpha 7 (neuronal) hsa:2556 GABRA3; gamma-aminobutyric acid (GABA) A receptor, alpha 3 hsa:2558 GABRA5; gamma-aminobutyric acid (GABA) A receptor, alpha 5 hsa:2562 GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3 hsa:2563 GABRD; gamma-aminobutyric acid (GABA) A receptor, delta hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1

hsa00230 Purine metabolism - Homo sapiens (human) (7)

hsa:100 ADA; adenosine deaminase (EC:3.5.4.4) hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:271 AMPD2; adenosine monophosphate deaminase 2 (EC:3.5.4.6) hsa:2272 FHIT; fragile histidine triad (EC:3.6.1.29) hsa:50940 PDE11A; phosphodiesterase 11A (EC:3.1.4.35 3.1.4.17) hsa:5136 PDE1A; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17)

hsa05162 Measles - Homo sapiens (human) (7)

hsa:894 CCND2; cyclin D2 hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor)

hsa05133 Pertussis - Homo sapiens (human) (7)

cpd:C00338 Lipopolysaccharide hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:3586 IL10; interleukin 10 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:7124 TNF; tumor necrosis factor

hsa04510 Focal adhesion - Homo sapiens (human) (7)

hsa:894 CCND2; cyclin D2 hsa:1950 EGF; epidermal growth factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (7)

hsa:894 CCND2; cyclin D2 hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3952 LEP; leptin hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor)

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (7)

cpd:C00735 Cortisol cpd:C01780 Aldosterone hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1588 CYP19A1; cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1543 CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

hsa05164 Influenza A - Homo sapiens (human) (7)

hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:7124 TNF; tumor necrosis factor

hsa04370 VEGF signaling pathway - Homo sapiens (human) (6)

cpd:C00533 Nitric oxide hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05132 Salmonella infection - Homo sapiens (human) (6)

cpd:C00338 Lipopolysaccharide cpd:C00533 Nitric oxide hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (6)

cpd:C00533 Nitric oxide hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15) hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:7124 TNF; tumor necrosis factor

hsa04970 Salivary secretion - Homo sapiens (human) (6)

cpd:C00533 Nitric oxide hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa05016 Huntington's disease - Homo sapiens (human) (6)

hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:627 BDNF; brain-derived neurotrophic factor hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)

hsa05134 Legionellosis - Homo sapiens (human) (6)

cpd:C00338 Lipopolysaccharide hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor

hsa04972 Pancreatic secretion - Homo sapiens (human) (6)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:886 CCKAR; cholecystokinin A receptor hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa05332 Graft-versus-host disease - Homo sapiens (human) (6)

hsa04971 Gastric acid secretion - Homo sapiens (human) (6)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:3776 KCNK2; potassium channel, subfamily K, member 2 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa00350 Tyrosine metabolism - Homo sapiens (human) (6)

hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:1312 COMT; catechol-O-methyltransferase (EC:2.1.1.6) hsa:1621 DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4)

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (6)

cpd:C00018 Pyridoxal phosphate cpd:C00504 Folate cpd:C05443 Vitamin D3 cpd:C05776 Vitamin B12 hsa:4363 ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1 hsa:2346 FOLH1; folate hydrolase (prostate-specific membrane antigen) 1 (EC:3.4.17.21)

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (6)

hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:1543 CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hsa:1545 CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) hsa:1559 CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18) hsa:3290 HSD11B1; hydroxysteroid (11-beta) dehydrogenase 1 (EC:1.1.1.146)

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (6)

hsa:627 BDNF; brain-derived neurotrophic factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:4804 NGFR; nerve growth factor receptor hsa:4915 NTRK2; neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) hsa:4916 NTRK3; neurotrophic tyrosine kinase, receptor, type 3 (EC:2.7.10.1) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4

hsa04912 GnRH signaling pathway - Homo sapiens (human) (5)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (5)

hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex) hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor

hsa04380 Osteoclast differentiation - Homo sapiens (human) (5)

hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:3458 IFNG; interferon, gamma hsa:3553 IL1B; interleukin 1, beta hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa04012 ErbB signaling pathway - Homo sapiens (human) (5)

hsa:1950 EGF; epidermal growth factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (5)

cpd:C00533 Nitric oxide hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:7124 TNF; tumor necrosis factor

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (5)

cpd:C00735 Cortisol cpd:C01780 Aldosterone hsa:4306 NR3C2; nuclear receptor subfamily 3, group C, member 2 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04530 Tight junction - Homo sapiens (human) (5)

hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:56288 PARD3; par-3 partitioning defective 3 homolog (C. elegans) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:5583 PRKCH; protein kinase C, eta (EC:2.7.11.13)

hsa05215 Prostate cancer - Homo sapiens (human) (5)

cpd:C00735 Cortisol hsa:367 AR; androgen receptor hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1950 EGF; epidermal growth factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (5)

hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:1559 CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4)

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (5)

hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (5)

hsa02010 ABC transporters - Homo sapiens (human) (5)

cpd:C00051 Glutathione cpd:C00338 Lipopolysaccharide cpd:C05776 Vitamin B12 hsa:5243 ABCB1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hsa:4363 ABCC1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (5)

hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (5)

hsa:3458 IFNG; interferon, gamma hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4 hsa:7124 TNF; tumor necrosis factor

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (5)

hsa:3952 LEP; leptin hsa:4852 NPY; neuropeptide Y hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7124 TNF; tumor necrosis factor

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (4)

cpd:C00338 Lipopolysaccharide hsa:1129 CHRM2; cholinergic receptor, muscarinic 2 hsa:1950 EGF; epidermal growth factor hsa:2247 FGF2; fibroblast growth factor 2 (basic)

hsa05110 Vibrio cholerae infection - Homo sapiens (human) (4)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa05330 Allograft rejection - Homo sapiens (human) (4)

cpd:C00533 Nitric oxide hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor

hsa00340 Histidine metabolism - Homo sapiens (human) (4)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4)

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (4)

hsa:1950 EGF; epidermal growth factor hsa:2272 FHIT; fragile histidine triad (EC:3.6.1.29) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04310 Wnt signaling pathway - Homo sapiens (human) (4)

hsa:894 CCND2; cyclin D2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (4)

cpd:C00078 L-Tryptophan hsa:2731 GLDC; glycine dehydrogenase (decarboxylating) (EC:1.4.4.2) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4)

hsa04210 Apoptosis - Homo sapiens (human) (4)

hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:1439 CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) hsa:3553 IL1B; interleukin 1, beta hsa:7124 TNF; tumor necrosis factor

hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human) (4)

cpd:C06428 (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid cpd:C06429 (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid hsa:3992 FADS1; fatty acid desaturase 1 (EC:1.14.19.-) hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-)

hsa04720 Long-term potentiation - Homo sapiens (human) (4)

hsa:775 CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit hsa:2902 GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04144 Endocytosis - Homo sapiens (human) (4)

cpd:C00504 Folate hsa:1950 EGF; epidermal growth factor hsa:56288 PARD3; par-3 partitioning defective 3 homolog (C. elegans) hsa:7040 TGFB1; transforming growth factor, beta 1

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (4)

hsa:6347 CCL2; chemokine (C-C motif) ligand 2 hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (4)

cpd:C00780 Serotonin hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6616 SNAP25; synaptosomal-associated protein, 25kDa

hsa05214 Glioma - Homo sapiens (human) (4)

hsa:1950 EGF; epidermal growth factor hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13) hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4

hsa05222 Small cell lung cancer - Homo sapiens (human) (4)

hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:2272 FHIT; fragile histidine triad (EC:3.6.1.29) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa04145 Phagosome - Homo sapiens (human) (4)

cpd:C00533 Nitric oxide hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:4074 M6PR; mannose-6-phosphate receptor (cation dependent) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)

hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) (4)

hsa:894 CCND2; cyclin D2 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4804 NGFR; nerve growth factor receptor hsa:8864 PER2; period homolog 2 (Drosophila)

hsa00410 beta-Alanine metabolism - Homo sapiens (human) (4)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa05212 Pancreatic cancer - Homo sapiens (human) (4)

hsa:1950 EGF; epidermal growth factor hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05169 Epstein-Barr virus infection - Homo sapiens (human) (4)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor)

hsa05160 Hepatitis C - Homo sapiens (human) (4)

hsa:1950 EGF; epidermal growth factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:6774 STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) hsa:7124 TNF; tumor necrosis factor

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (3)

hsa:1559 CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (3)

hsa:1644 DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase) (EC:4.1.1.28) hsa:4128 MAOA; monoamine oxidase A (EC:1.4.3.4) hsa:4129 MAOB; monoamine oxidase B (EC:1.4.3.4)

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (3)

hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:7124 TNF; tumor necrosis factor

hsa04740 Olfactory transduction - Homo sapiens (human) (3)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:2774 GNAL; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type hsa:119765 OR4B1; olfactory receptor, family 4, subfamily B, member 1

hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human) (3)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:551 AVP; arginine vasopressin hsa:1385 CREB1; cAMP responsive element binding protein 1

hsa00650 Butanoate metabolism - Homo sapiens (human) (3)

hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (3)

hsa:3458 IFNG; interferon, gamma hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7124 TNF; tumor necrosis factor

hsa05012 Parkinson's disease - Homo sapiens (human) (3)

hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:6570 SLC18A1; solute carrier family 18 (vesicular monoamine), member 1 hsa:6531 SLC6A3; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

hsa04110 Cell cycle - Homo sapiens (human) (3)

hsa:894 CCND2; cyclin D2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:7040 TGFB1; transforming growth factor, beta 1

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (3)

hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (3)

hsa:1103 CHAT; choline O-acetyltransferase (EC:2.3.1.6) hsa:160851 DGKH; diacylglycerol kinase, eta (EC:2.7.1.107) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)

hsa04612 Antigen processing and presentation - Homo sapiens (human) (3)

hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:3458 IFNG; interferon, gamma hsa:7124 TNF; tumor necrosis factor

hsa04360 Axon guidance - Homo sapiens (human) (3)

hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:6586 SLIT3; slit homolog 3 (Drosophila)

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (3)

cpd:C00019 S-Adenosyl-L-methionine cpd:C00051 Glutathione cpd:C00155 L-Homocysteine

hsa00830 Retinol metabolism - Homo sapiens (human) (3)

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (3)

hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa00071 Fatty acid metabolism - Homo sapiens (human) (3)

hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17)

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (3)

hsa:3586 IL10; interleukin 10 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7040 TGFB1; transforming growth factor, beta 1

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (3)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:2773 GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (3)

hsa:160851 DGKH; diacylglycerol kinase, eta (EC:2.7.1.107) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04910 Insulin signaling pathway - Homo sapiens (human) (3)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:10891 PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha hsa:399694 SHC4; SHC (Src homology 2 domain containing) family, member 4

hsa04114 Oocyte meiosis - Homo sapiens (human) (3)

hsa:109 ADCY3; adenylate cyclase 3 (EC:4.6.1.1) hsa:113 ADCY7; adenylate cyclase 7 (EC:4.6.1.1) hsa:367 AR; androgen receptor

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (3)

hsa:3458 IFNG; interferon, gamma hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor

hsa04146 Peroxisome - Homo sapiens (human) (3)

hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:6648 SOD2; superoxide dismutase 2, mitochondrial (EC:1.15.1.1)

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (3)

hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:7124 TNF; tumor necrosis factor

hsa04115 p53 signaling pathway - Homo sapiens (human) (3)

hsa:317 APAF1; apoptotic peptidase activating factor 1 hsa:894 CCND2; cyclin D2 hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (3)

hsa:2099 ESR1; estrogen receptor 1 hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13) hsa:5582 PRKCG; protein kinase C, gamma (EC:2.7.11.13)

hsa04614 Renin-angiotensin system - Homo sapiens (human) (2)

hsa:1636 ACE; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (EC:3.4.15.1) hsa:185 AGTR1; angiotensin II receptor, type 1

hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human) (2)

hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-) hsa:5321 PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) (EC:3.1.1.5 3.1.1.4)

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (2)

hsa:125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide (EC:1.1.1.1) hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3)

hsa00670 One carbon pool by folate - Homo sapiens (human) (2)

cpd:C00504 Folate hsa:4524 MTHFR; methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20)

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (2)

hsa:22871 NLGN1; neuroligin 1 hsa:1462 VCAN; versican

hsa05210 Colorectal cancer - Homo sapiens (human) (2)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:7040 TGFB1; transforming growth factor, beta 1

hsa00430 Taurine and hypotaurine metabolism - Homo sapiens (human) (2)

hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human) (2)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17)

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (2)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:5054 SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

hsa04142 Lysosome - Homo sapiens (human) (2)

hsa:9741 LAPTM4A; lysosomal protein transmembrane 4 alpha hsa:4074 M6PR; mannose-6-phosphate receptor (cation dependent)

hsa00640 Propanoate metabolism - Homo sapiens (human) (2)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17)

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (2)

hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2)

hsa05211 Renal cell carcinoma - Homo sapiens (human) (2)

hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05218 Melanoma - Homo sapiens (human) (2)

hsa:1950 EGF; epidermal growth factor hsa:2247 FGF2; fibroblast growth factor 2 (basic)

hsa04974 Protein digestion and absorption - Homo sapiens (human) (2)

cpd:C00078 L-Tryptophan hsa:1803 DPP4; dipeptidyl-peptidase 4 (EC:3.4.14.5)

hsa05213 Endometrial cancer - Homo sapiens (human) (2)

hsa:1950 EGF; epidermal growth factor hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)

hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human) (2)

hsa:2571 GAD1; glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) hsa:2572 GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15)

hsa05219 Bladder cancer - Homo sapiens (human) (2)

hsa:1950 EGF; epidermal growth factor hsa:7422 VEGFA; vascular endothelial growth factor A

hsa05340 Primary immunodeficiency - Homo sapiens (human) (2)

hsa:100 ADA; adenosine deaminase (EC:3.5.4.4) hsa:916 CD3E; CD3e molecule, epsilon (CD3-TCR complex)

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (2)

hsa:7466 WFS1; Wolfram syndrome 1 (wolframin) hsa:7494 XBP1; X-box binding protein 1

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (2)

hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) hsa:5579 PRKCB; protein kinase C, beta (EC:2.7.11.13)

hsa00480 Glutathione metabolism - Homo sapiens (human) (2)

cpd:C00051 Glutathione hsa:2952 GSTT1; glutathione S-transferase theta 1 (EC:2.5.1.18)

hsa00591 Linoleic acid metabolism - Homo sapiens (human) (2)

hsa05310 Asthma - Homo sapiens (human) (2)

hsa:3586 IL10; interleukin 10 hsa:7124 TNF; tumor necrosis factor

hsa04742 Taste transduction - Homo sapiens (human) (2)

hsa:2784 GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3 hsa:5136 PDE1A; phosphodiesterase 1A, calmodulin-dependent (EC:3.1.4.17)

hsa05020 Prion diseases - Homo sapiens (human) (2)

hsa:3553 IL1B; interleukin 1, beta hsa:3569 IL6; interleukin 6 (interferon, beta 2)

hsa00310 Lysine degradation - Homo sapiens (human) (2)

hsa:217 ALDH2; aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17)

hsa00920 Sulfur metabolism - Homo sapiens (human) (2)

cpd:C00155 L-Homocysteine hsa:6817 SULT1A1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)

hsa03320 PPAR signaling pathway - Homo sapiens (human) (2)

hsa:1962 EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (EC:1.1.1.35 5.3.3.8 4.2.1.17) hsa:9415 FADS2; fatty acid desaturase 2 (EC:1.14.19.-)

hsa03050 Proteasome - Homo sapiens (human) (2)

hsa:3458 IFNG; interferon, gamma hsa:5692 PSMB4; proteasome (prosome, macropain) subunit, beta type, 4 (EC:3.4.25.1)

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (2)

hsa:526 ATP6V1B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (EC:3.6.3.14) hsa:64077 LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC:3.6.1.1)

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (2)