Herpes simplex

hsa05200 Pathways in cancer - Homo sapiens (human) (48)

cpd:C00187 Cholesterol cpd:C00410 Progesterone cpd:C00735 Cortisol cpd:C00777 Retinoate cpd:C00951 Estradiol-17beta cpd:C15493 9-cis-Retinoic acid hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:2956 MSH6; mutS homolog 6 (E. coli) hsa:3065 HDAC1; histone deacetylase 1 (EC:3.5.1.98) hsa:3066 HDAC2; histone deacetylase 2 (EC:3.5.1.98) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4088 SMAD3; SMAD family member 3 hsa:4436 MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) hsa:4437 MSH3; mutS homolog 3 (E. coli) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5371 PML; promyelocytic leukemia hsa:54205 CYCS; cytochrome c, somatic hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:581 BAX; BCL2-associated X protein hsa:595 CCND1; cyclin D1 hsa:637 BID; BH3 interacting domain death agonist hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05164 Influenza A - Homo sapiens (human) (44)

hsa:10482 NXF1; nuclear RNA export factor 1 hsa:1386 ATF2; activating transcription factor 2 hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1965 EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3337 DNAJB1; DnaJ (Hsp40) homolog, subfamily B, member 1 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:3661 IRF3; interferon regulatory factor 3 hsa:3836 KPNA1; karyopherin alpha 1 (importin alpha 5) hsa:3838 KPNA2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2',5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.-) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5371 PML; promyelocytic leukemia hsa:54205 CYCS; cytochrome c, somatic hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:60 ACTB; actin, beta hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:71 ACTG1; actin, gamma 1 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7514 XPO1; exportin 1 (CRM1 homolog, yeast) hsa:9451 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1)

hsa05152 Tuberculosis - Homo sapiens (human) (37)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:30835 CD209; CD209 molecule hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4800 NFYA; nuclear transcription factor Y, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:54205 CYCS; cytochrome c, somatic hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:637 BID; BH3 interacting domain death agonist hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:7879 RAB7A; RAB7A, member RAS oncogene family hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)

hsa05162 Measles - Homo sapiens (human) (30)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1460 CSNK2B; casein kinase 2, beta polypeptide (EC:2.7.11.1) hsa:1965 EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:30835 CD209; CD209 molecule hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3661 IRF3; interferon regulatory factor 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2',5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.-) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7097 TLR2; toll-like receptor 2 hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:896 CCND3; cyclin D3 hsa:9451 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1)

hsa05145 Toxoplasmosis - Homo sapiens (human) (29)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:54205 CYCS; cytochrome c, somatic hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8651 SOCS1; suppressor of cytokine signaling 1

hsa04010 MAPK signaling pathway - Homo sapiens (human) (28)

cpd:C00575 3',5'-Cyclic AMP hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1386 ATF2; activating transcription factor 2 hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3727 JUND; jun D proto-oncogene hsa:409 ARRB2; arrestin, beta 2 hsa:4137 MAPT; microtubule-associated protein tau hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4803 NGF; nerve growth factor (beta polypeptide) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05160 Hepatitis C - Homo sapiens (human) (27)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:1965 EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3661 IRF3; interferon regulatory factor 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4938 OAS1; 2',5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.-) hsa:4939 OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa (EC:2.7.7.-) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:572 BAD; BCL2-associated agonist of cell death hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8737 RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1) hsa:9451 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1)

hsa04144 Endocytosis - Homo sapiens (human) (25)

hsa:10015 PDCD6IP; programmed cell death 6 interacting protein hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:25978 CHMP2B; chromatin modifying protein 2B hsa:27183 VPS4A; vacuolar protein sorting 4 homolog A (S. cerevisiae) hsa:30011 SH3KBP1; SH3-domain kinase binding protein 1 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:4088 SMAD3; SMAD family member 3 hsa:409 ARRB2; arrestin, beta 2 hsa:5371 PML; promyelocytic leukemia hsa:57132 CHMP1B; chromatin modifying protein 1B hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:64750 SMURF2; SMAD specific E3 ubiquitin protein ligase 2 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:7879 RAB7A; RAB7A, member RAS oncogene family hsa:79643 CHMP6; chromatin modifying protein 6 hsa:83737 ITCH; itchy E3 ubiquitin protein ligase homolog (mouse) hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:8766 RAB11A; RAB11A, member RAS oncogene family hsa:9525 VPS4B; vacuolar protein sorting 4 homolog B (S. cerevisiae) hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05215 Prostate cancer - Homo sapiens (human) (25)

cpd:C00410 Progesterone cpd:C00735 Cortisol cpd:C00951 Estradiol-17beta hsa:10488 CREB3; cAMP responsive element binding protein 3 hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa01100 Metabolic pathways - Homo sapiens (human) (25) (No map)

cpd:C00051 Glutathione cpd:C00078 L-Tryptophan cpd:C00187 Cholesterol cpd:C00410 Progesterone cpd:C00473 Retinol cpd:C00681 1-Acyl-sn-glycerol 3-phosphate cpd:C00735 Cortisol cpd:C00745 Nicotine cpd:C00777 Retinoate cpd:C00788 L-Adrenaline cpd:C00951 Estradiol-17beta cpd:C01516 Morphine cpd:C01829 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine cpd:C02140 Corticosterone hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6) hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:522 ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) hsa:5422 POLA1; polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6916 TBXAS1; thromboxane A synthase 1 (platelet) (EC:5.3.99.5) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) (25)

cpd:C00575 3',5'-Cyclic AMP hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:4088 SMAD3; SMAD family member 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:811 CALR; calreticulin hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8837 CFLAR; CASP8 and FADD-like apoptosis regulator

hsa04145 Phagosome - Homo sapiens (human) (24)

hsa:10376 TUBA1B; tubulin, alpha 1b hsa:1780 DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 hsa:30835 CD209; CD209 molecule hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:4074 M6PR; mannose-6-phosphate receptor (cation dependent) hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:60 ACTB; actin, beta hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:7097 TLR2; toll-like receptor 2 hsa:71 ACTG1; actin, gamma 1 hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:7879 RAB7A; RAB7A, member RAS oncogene family hsa:811 CALR; calreticulin hsa:821 CANX; calnexin

hsa05010 Alzheimer's disease - Homo sapiens (human) (22)

hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81) hsa:23385 NCSTN; nicastrin hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3416 IDE; insulin-degrading enzyme (EC:3.4.24.56) hsa:348 APOE; apolipoprotein E hsa:351 APP; amyloid beta (A4) precursor protein hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:4137 MAPT; microtubule-associated protein tau hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans) hsa:522 ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) hsa:54205 CYCS; cytochrome c, somatic hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4) hsa:572 BAD; BCL2-associated agonist of cell death hsa:637 BID; BH3 interacting domain death agonist hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:9451 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1)

hsa04380 Osteoclast differentiation - Homo sapiens (human) (21)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:3727 JUND; jun D proto-oncogene hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8651 SOCS1; suppressor of cytokine signaling 1

hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) (21)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3661 IRF3; interferon regulatory factor 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7097 TLR2; toll-like receptor 2 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8737 RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1)

hsa04210 Apoptosis - Homo sapiens (human) (19)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4803 NGF; nerve growth factor (beta polypeptide) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:54205 CYCS; cytochrome c, somatic hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:637 BID; BH3 interacting domain death agonist hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8737 RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1) hsa:8837 CFLAR; CASP8 and FADD-like apoptosis regulator

hsa05016 Huntington's disease - Homo sapiens (human) (19)

hsa:10488 CREB3; cAMP responsive element binding protein 3 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1639 DCTN1; dynactin 1 hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:23186 RCOR1; REST corepressor 1 hsa:25942 SIN3A; SIN3 homolog A, transcription regulator (yeast) hsa:292 SLC25A5; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 hsa:3065 HDAC1; histone deacetylase 1 (EC:3.5.1.98) hsa:3066 HDAC2; histone deacetylase 2 (EC:3.5.1.98) hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:522 ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) hsa:54205 CYCS; cytochrome c, somatic hsa:581 BAX; BCL2-associated X protein hsa:5978 REST; RE1-silencing transcription factor hsa:6667 SP1; Sp1 transcription factor hsa:7157 TP53; tumor protein p53 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)

hsa05140 Leishmaniasis - Homo sapiens (human) (19)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:7189 TRAF6; TNF receptor-associated factor 6

hsa04110 Cell cycle - Homo sapiens (human) (18)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:27127 SMC1B; structural maintenance of chromosomes 1B hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3065 HDAC1; histone deacetylase 1 (EC:3.5.1.98) hsa:3066 HDAC2; histone deacetylase 2 (EC:3.5.1.98) hsa:4088 SMAD3; SMAD family member 3 hsa:4171 MCM2; minichromosome maintenance complex component 2 (EC:3.6.4.12) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5591 PRKDC; protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) hsa:595 CCND1; cyclin D1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:8243 SMC1A; structural maintenance of chromosomes 1A hsa:896 CCND3; cyclin D3 hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) hsa:995 CDC25C; cell division cycle 25 homolog C (S. pombe) (EC:3.1.3.48)

hsa04062 Chemokine signaling pathway - Homo sapiens (human) (18)

cpd:C00575 3',5'-Cyclic AMP hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:409 ARRB2; arrestin, beta 2 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) (18)

hsa:1965 EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa hsa:26232 FBXO2; F-box protein 2 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3337 DNAJB1; DnaJ (Hsp40) homolog, subfamily B, member 1 hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5610 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 (EC:2.7.11.1) hsa:581 BAX; BCL2-associated X protein hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:7321 UBE2D1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) (EC:6.3.2.19) hsa:7324 UBE2E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) (EC:6.3.2.19) hsa:811 CALR; calreticulin hsa:821 CANX; calnexin hsa:9451 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1)

hsa03013 RNA transport - Homo sapiens (human) (17)

hsa:10189 THOC4; THO complex 4 hsa:10482 NXF1; nuclear RNA export factor 1 hsa:11097 NUPL2; nucleoporin like 2 hsa:129401 NUP35; nucleoporin 35kDa hsa:1915 EEF1A1; eukaryotic translation elongation factor 1 alpha 1 hsa:1965 EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa hsa:1974 EIF4A2; eukaryotic translation initiation factor 4A2 (EC:3.6.4.13) hsa:1975 EIF4B; eukaryotic translation initiation factor 4B hsa:1977 EIF4E; eukaryotic translation initiation factor 4E hsa:1981 EIF4G1; eukaryotic translation initiation factor 4 gamma, 1 hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1 hsa:3837 KPNB1; karyopherin (importin) beta 1 hsa:5903 RANBP2; RAN binding protein 2 hsa:7514 XPO1; exportin 1 (CRM1 homolog, yeast) hsa:8021 NUP214; nucleoporin 214kDa hsa:8662 EIF3B; eukaryotic translation initiation factor 3, subunit B hsa:8665 EIF3F; eukaryotic translation initiation factor 3, subunit F EIF3M eukaryotic translation initiation factor 3, subunit M belongs here: (binds to EIF3F and EIF4A2)

hsa04612 Antigen processing and presentation - Homo sapiens (human) (17)

hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3458 IFNG; interferon, gamma hsa:4800 NFYA; nuclear transcription factor Y, alpha hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:811 CALR; calreticulin hsa:821 CANX; calnexin

hsa05220 Chronic myeloid leukemia - Homo sapiens (human) (17)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3065 HDAC1; histone deacetylase 1 (EC:3.5.1.98) hsa:3066 HDAC2; histone deacetylase 2 (EC:3.5.1.98) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4088 SMAD3; SMAD family member 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence

hsa05212 Pancreatic cancer - Homo sapiens (human) (17)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4088 SMAD3; SMAD family member 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) (17)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4803 NGF; nerve growth factor (beta polypeptide) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) (16)

hsa:1072 CFL1; cofilin 1 (non-muscle) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:4627 MYH9; myosin, heavy chain 9, non-muscle hsa:5216 PFN1; profilin 1 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05222 Small cell lung cancer - Homo sapiens (human) (16)

cpd:C00777 Retinoate cpd:C15493 9-cis-Retinoic acid hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:54205 CYCS; cytochrome c, somatic hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa04510 Focal adhesion - Homo sapiens (human) (16)

hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:896 CCND3; cyclin D3 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05416 Viral myocarditis - Homo sapiens (human) (16)

hsa:1981 EIF4G1; eukaryotic translation initiation factor 4 gamma, 1 hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4627 MYH9; myosin, heavy chain 9, non-muscle hsa:54205 CYCS; cytochrome c, somatic hsa:595 CCND1; cyclin D1 hsa:60 ACTB; actin, beta hsa:637 BID; BH3 interacting domain death agonist hsa:71 ACTG1; actin, gamma 1 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)

hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) (15)

hsa:1462 VCAN; versican hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:5818 PVRL1; poliovirus receptor-related 1 (herpesvirus entry mediator C) hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B) hsa:6382 SDC1; syndecan 1 hsa:6383 SDC2; syndecan 2 hsa:6385 SDC4; syndecan 4 hsa:9672 SDC3; syndecan 3

hsa05210 Colorectal cancer - Homo sapiens (human) (15)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:2956 MSH6; mutS homolog 6 (E. coli) hsa:4088 SMAD3; SMAD family member 3 hsa:4436 MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) hsa:4437 MSH3; mutS homolog 3 (E. coli) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:54205 CYCS; cytochrome c, somatic hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:595 CCND1; cyclin D1 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7157 TP53; tumor protein p53 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa05144 Malaria - Homo sapiens (human) (15)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3039 HBA1; hemoglobin, alpha 1 hsa:3040 HBA2; hemoglobin, alpha 2 hsa:3043 HBB; hemoglobin, beta hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:6382 SDC1; syndecan 1 hsa:6383 SDC2; syndecan 2 hsa:6385 SDC4; syndecan 4 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:9672 SDC3; syndecan 3

hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) (15)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:595 CCND1; cyclin D1 hsa:6772 STAT1; signal transducer and activator of transcription 1, 91kDa hsa:8651 SOCS1; suppressor of cytokine signaling 1 hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:896 CCND3; cyclin D3

hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) (14)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:3661 IRF3; interferon regulatory factor 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8737 RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1)

hsa05323 Rheumatoid arthritis - Homo sapiens (human) (14)

hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2

hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) (14)

hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:6348 CCL3; chemokine (C-C motif) ligand 3 hsa:6351 CCL4; chemokine (C-C motif) ligand 4 hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:8764 TNFRSF14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) (14)

hsa:26232 FBXO2; F-box protein 2 hsa:27339 PRPF19; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) hsa:5371 PML; promyelocytic leukemia hsa:64750 SMURF2; SMAD specific E3 ubiquitin protein ligase 2 hsa:6477 SIAH1; seven in absentia homolog 1 (Drosophila) (EC:6.3.2.-) hsa:672 BRCA1; breast cancer 1, early onset hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:7321 UBE2D1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) (EC:6.3.2.19) hsa:7324 UBE2E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) (EC:6.3.2.19) hsa:7332 UBE2L3; ubiquitin-conjugating enzyme E2L 3 (EC:6.3.2.19) hsa:83737 ITCH; itchy E3 ubiquitin protein ligase homolog (mouse) hsa:8651 SOCS1; suppressor of cytokine signaling 1 hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:997 CDC34; cell division cycle 34 homolog (S. cerevisiae) (EC:6.3.2.19)

hsa04910 Insulin signaling pathway - Homo sapiens (human) (14)

cpd:C00575 3',5'-Cyclic AMP hsa:1977 EIF4E; eukaryotic translation initiation factor 4E hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:572 BAD; BCL2-associated agonist of cell death hsa:7249 TSC2; tuberous sclerosis 2 hsa:8651 SOCS1; suppressor of cytokine signaling 1 hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence

hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) (14)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1654 DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (EC:3.6.4.13) hsa:29110 TBK1; TANK-binding kinase 1 (EC:2.7.11.1) hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3661 IRF3; interferon regulatory factor 3 hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:8737 RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 (EC:2.7.11.1)

hsa04660 T cell receptor signaling pathway - Homo sapiens (human) (14)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3458 IFNG; interferon, gamma hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05146 Amoebiasis - Homo sapiens (human) (14)

cpd:C00575 3',5'-Cyclic AMP hsa:3458 IFNG; interferon, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:7097 TLR2; toll-like receptor 2 hsa:7879 RAB7A; RAB7A, member RAS oncogene family hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa04310 Wnt signaling pathway - Homo sapiens (human) (13)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1460 CSNK2B; casein kinase 2, beta polypeptide (EC:2.7.11.1) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:4088 SMAD3; SMAD family member 3 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:595 CCND1; cyclin D1 hsa:6477 SIAH1; seven in absentia homolog 1 (Drosophila) (EC:6.3.2.-) hsa:7157 TP53; tumor protein p53 hsa:8607 RUVBL1; RuvB-like 1 (E. coli) (EC:3.6.4.12) hsa:896 CCND3; cyclin D3

hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) (13)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:7184 HSP90B1; heat shock protein 90kDa beta (Grp94), member 1 hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa05133 Pertussis - Homo sapiens (human) (13)

cpd:C00575 3',5'-Cyclic AMP hsa:1072 CFL1; cofilin 1 (non-muscle) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3661 IRF3; interferon regulatory factor 3 hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:7189 TRAF6; TNF receptor-associated factor 6 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) (13)

hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79) hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3439 IFNA1; interferon, alpha 1 hsa:3456 IFNB1; interferon, beta 1, fibroblast hsa:3458 IFNG; interferon, gamma hsa:3459 IFNGR1; interferon gamma receptor 1 hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:637 BID; BH3 interacting domain death agonist hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa05131 Shigellosis - Homo sapiens (human) (12)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5216 PFN1; profilin 1 hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:7307 U2AF1; U2 small nuclear RNA auxiliary factor 1 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05322 Systemic lupus erythematosus - Homo sapiens (human) (12)

hsa:121504 HIST4H4; histone cluster 4, H4 hsa:3020 H3F3A; H3 histone, family 3A hsa:3021 H3F3B; H3 histone, family 3B (H3.3B) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3458 IFNG; interferon, gamma hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:8290 HIST3H3; histone cluster 3, H3 hsa:8350 HIST1H3A; histone cluster 1, H3a

hsa03040 Spliceosome - Homo sapiens (human) (12)

hsa:10189 THOC4; THO complex 4 hsa:10992 SF3B2; splicing factor 3b, subunit 2, 145kDa hsa:1655 DDX5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (EC:3.6.4.13) hsa:23451 SF3B1; splicing factor 3b, subunit 1, 155kDa hsa:27339 PRPF19; PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) hsa:3190 HNRNPK; heterogeneous nuclear ribonucleoprotein K hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3305 HSPA1L; heat shock 70kDa protein 1-like hsa:3312 HSPA8; heat shock 70kDa protein 8 hsa:6428 SRSF3; serine/arginine-rich splicing factor 3 hsa:6432 SRSF7; serine/arginine-rich splicing factor 7 hsa:7307 U2AF1; U2 small nuclear RNA auxiliary factor 1

hsa04115 p53 signaling pathway - Homo sapiens (human) (12)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:54205 CYCS; cytochrome c, somatic hsa:581 BAX; BCL2-associated X protein hsa:595 CCND1; cyclin D1 hsa:637 BID; BH3 interacting domain death agonist hsa:6477 SIAH1; seven in absentia homolog 1 (Drosophila) (EC:6.3.2.-) hsa:7157 TP53; tumor protein p53 hsa:7249 TSC2; tuberous sclerosis 2 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:841 CASP8; caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) hsa:896 CCND3; cyclin D3 hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa05223 Non-small cell lung cancer - Homo sapiens (human) (11)

cpd:C00777 Retinoate cpd:C15493 9-cis-Retinoic acid hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53

hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) (11)

hsa:102 ADAM10; ADAM metallopeptidase domain 10 (EC:3.4.24.81) hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:6352 CCL5; chemokine (C-C motif) ligand 5 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04610 Complement and coagulation cascades - Homo sapiens (human) (11)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:2 A2M; alpha-2-macroglobulin hsa:2152 F3; coagulation factor III (thromboplastin, tissue factor) hsa:2157 F8; coagulation factor VIII, procoagulant component hsa:2158 F9; coagulation factor IX (EC:3.4.21.22) hsa:2159 F10; coagulation factor X (EC:3.4.21.6) hsa:2160 F11; coagulation factor XI (EC:3.4.21.27) hsa:2161 F12; coagulation factor XII (Hageman factor) (EC:3.4.21.38) hsa:2162 F13A1; coagulation factor XIII, A1 polypeptide (EC:2.3.2.13) hsa:718 C3; complement component 3 (EC:3.4.21.43) hsa:966 CD59; CD59 molecule, complement regulatory protein

hsa04520 Adherens junction - Homo sapiens (human) (11)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:1460 CSNK2B; casein kinase 2, beta polypeptide (EC:2.7.11.1) hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:4088 SMAD3; SMAD family member 3 hsa:5818 PVRL1; poliovirus receptor-related 1 (herpesvirus entry mediator C) hsa:5819 PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05221 Acute myeloid leukemia - Homo sapiens (human) (10)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5371 PML; promyelocytic leukemia hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa04540 Gap junction - Homo sapiens (human) (10)

cpd:C00575 3',5'-Cyclic AMP cpd:C00681 1-Acyl-sn-glycerol 3-phosphate cpd:C00942 3',5'-Cyclic GMP hsa:10376 TUBA1B; tubulin, alpha 1b hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)

hsa05218 Melanoma - Homo sapiens (human) (10)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2247 FGF2; fibroblast growth factor 2 (basic) hsa:2260 FGFR1; fibroblast growth factor receptor 1 (EC:2.7.10.1) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:572 BAD; BCL2-associated agonist of cell death hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53

hsa04330 Notch signaling pathway - Homo sapiens (human) (10)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:23385 NCSTN; nicastrin hsa:3065 HDAC1; histone deacetylase 1 (EC:3.5.1.98) hsa:3066 HDAC2; histone deacetylase 2 (EC:3.5.1.98) hsa:51107 APH1A; anterior pharynx defective 1 homolog A (C. elegans) hsa:55851 PSENEN; presenilin enhancer 2 homolog (C. elegans) hsa:5663 PSEN1; presenilin 1 (EC:3.4.23.-) hsa:5664 PSEN2; presenilin 2 (Alzheimer disease 4) hsa:8850 KAT2B; K(lysine) acetyltransferase 2B (EC:2.3.1.48)

hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) (10)

cpd:C00777 Retinoate cpd:C15493 9-cis-Retinoic acid hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:57379 AICDA; activation-induced cytidine deaminase (EC:3.5.4.5) hsa:7040 TGFB1; transforming growth factor, beta 1

hsa05150 Staphylococcus aureus infection - Homo sapiens (human) (10)

hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:3858 KRT10; keratin 10 hsa:718 C3; complement component 3 (EC:3.4.21.43)

hsa04912 GnRH signaling pathway - Homo sapiens (human) (9)

cpd:C00575 3',5'-Cyclic AMP hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04640 Hematopoietic cell lineage - Homo sapiens (human) (9)

hsa:1378 CR1; complement component (3b/4b) receptor 1 (Knops blood group) hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:966 CD59; CD59 molecule, complement regulatory protein

hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human) (9)

cpd:C00575 3',5'-Cyclic AMP hsa:10488 CREB3; cAMP responsive element binding protein 3 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1639 DCTN1; dynactin 1 hsa:1780 DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:8655 DYNLL1; dynein, light chain, LC8-type 1 hsa:8766 RAB11A; RAB11A, member RAS oncogene family

hsa04012 ErbB signaling pathway - Homo sapiens (human) (9)

hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) (9)

hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:54205 CYCS; cytochrome c, somatic hsa:572 BAD; BCL2-associated agonist of cell death hsa:581 BAX; BCL2-associated X protein hsa:5868 RAB5A; RAB5A, member RAS oncogene family hsa:637 BID; BH3 interacting domain death agonist hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:7157 TP53; tumor protein p53 hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa05213 Endometrial cancer - Homo sapiens (human) (9)

hsa05143 African trypanosomiasis - Homo sapiens (human) (9)

cpd:C00078 L-Tryptophan hsa:3039 HBA1; hemoglobin, alpha 1 hsa:3040 HBA2; hemoglobin, alpha 2 hsa:3043 HBB; hemoglobin, beta hsa:335 APOA1; apolipoprotein A-I hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3458 IFNG; interferon, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3606 IL18; interleukin 18 (interferon-gamma-inducing factor)

hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) (9)

cpd:C00575 3',5'-Cyclic AMP hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2) hsa:3383 ICAM1; intercellular adhesion molecule 1 hsa:3684 ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) hsa:3689 ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) (9)

cpd:C00410 Progesterone cpd:C00575 3',5'-Cyclic AMP hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3320 HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) hsa:995 CDC25C; cell division cycle 25 homolog C (S. pombe) (EC:3.1.3.48)

hsa04662 B cell receptor signaling pathway - Homo sapiens (human) (9)

hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa04114 Oocyte meiosis - Homo sapiens (human) (9)

cpd:C00410 Progesterone cpd:C00575 3',5'-Cyclic AMP hsa:27127 SMC1B; structural maintenance of chromosomes 1B hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:8243 SMC1A; structural maintenance of chromosomes 1A hsa:983 CDK1; cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) hsa:995 CDC25C; cell division cycle 25 homolog C (S. pombe) (EC:3.1.3.48)

hsa05020 Prion diseases - Homo sapiens (human) (9)

cpd:C00575 3',5'-Cyclic AMP cpd:C02140 Corticosterone hsa:1958 EGR1; early growth response 1 hsa:3303 HSPA1A; heat shock 70kDa protein 1A hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:581 BAX; BCL2-associated X protein hsa:6352 CCL5; chemokine (C-C motif) ligand 5

hsa05414 Dilated cardiomyopathy - Homo sapiens (human) (9)

cpd:C00575 3',5'-Cyclic AMP hsa:2010 EMD; emerin hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:4000 LMNA; lamin A/C hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:60 ACTB; actin, beta hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:71 ACTG1; actin, gamma 1

hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) (9)

cpd:C15493 9-cis-Retinoic acid hsa:1147 CHUK; conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:4790 NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 hsa:4792 NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:7132 TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa04976 Bile secretion - Homo sapiens (human) (8)

cpd:C00051 Glutathione cpd:C00187 Cholesterol cpd:C00575 3',5'-Cyclic AMP cpd:C00735 Cortisol cpd:C00942 3',5'-Cyclic GMP cpd:C01829 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine cpd:C06810 Acyclovir hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04512 ECM-receptor interaction - Homo sapiens (human) (8)

hsa:3339 HSPG2; heparan sulfate proteoglycan 2 hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:375790 AGRN; agrin hsa:6382 SDC1; syndecan 1 hsa:6383 SDC2; syndecan 2 hsa:6385 SDC4; syndecan 4 hsa:9672 SDC3; syndecan 3

hsa05320 Autoimmune thyroid disease - Homo sapiens (human) (8)

cpd:C01829 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3439 IFNA1; interferon, alpha 1

hsa03430 Mismatch repair - Homo sapiens (human) (8)

hsa:2956 MSH6; mutS homolog 6 (E. coli) hsa:29935 RPA4; replication protein A4, 30kDa hsa:4436 MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) hsa:4437 MSH3; mutS homolog 3 (E. coli) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:6117 RPA1; replication protein A1, 70kDa hsa:6118 RPA2; replication protein A2, 32kDa hsa:6119 RPA3; replication protein A3, 14kDa

hsa05214 Glioma - Homo sapiens (human) (8)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53

hsa04725 Cholinergic synapse - Homo sapiens (human) (8)

cpd:C00575 3',5'-Cyclic AMP hsa:10488 CREB3; cAMP responsive element binding protein 3 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) (8)

hsa:2010 EMD; emerin hsa:3569 IL6; interleukin 6 (interferon, beta 2) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:4000 LMNA; lamin A/C hsa:60 ACTB; actin, beta hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:71 ACTG1; actin, gamma 1

hsa05332 Graft-versus-host disease - Homo sapiens (human) (8)

hsa:3002 GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (EC:3.4.21.79) hsa:3108 HLA-DMA; major histocompatibility complex, class II, DM alpha hsa:3109 HLA-DMB; major histocompatibility complex, class II, DM beta hsa:3123 HLA-DRB1; major histocompatibility complex, class II, DR beta 1 hsa:3125 HLA-DRB3; major histocompatibility complex, class II, DR beta 3 hsa:3126 HLA-DRB4; major histocompatibility complex, class II, DR beta 4 hsa:3458 IFNG; interferon, gamma hsa:3569 IL6; interleukin 6 (interferon, beta 2)

hsa03440 Homologous recombination - Homo sapiens (human) (8)

hsa:10111 RAD50; RAD50 homolog (S. cerevisiae) hsa:29935 RPA4; replication protein A4, 30kDa hsa:4361 MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hsa:4683 NBN; nibrin hsa:6117 RPA1; replication protein A1, 70kDa hsa:6118 RPA2; replication protein A2, 32kDa hsa:6119 RPA3; replication protein A3, 14kDa hsa:641 BLM; Bloom syndrome, RecQ helicase-like (EC:3.6.4.12)

hsa04020 Calcium signaling pathway - Homo sapiens (human) (8)

cpd:C00575 3',5'-Cyclic AMP hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2185 PTK2B; PTK2B protein tyrosine kinase 2 beta (EC:2.7.10.2) hsa:292 SLC25A5; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa05330 Allograft rejection - Homo sapiens (human) (7)

hsa03030 DNA replication - Homo sapiens (human) (7)

hsa:29935 RPA4; replication protein A4, 30kDa hsa:4171 MCM2; minichromosome maintenance complex component 2 (EC:3.6.4.12) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:5422 POLA1; polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7) hsa:6117 RPA1; replication protein A1, 70kDa hsa:6118 RPA2; replication protein A2, 32kDa hsa:6119 RPA3; replication protein A3, 14kDa

hsa04350 TGF-beta signaling pathway - Homo sapiens (human) (7)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:3458 IFNG; interferon, gamma hsa:4088 SMAD3; SMAD family member 3 hsa:64750 SMURF2; SMAD specific E3 ubiquitin protein ligase 2 hsa:6667 SP1; Sp1 transcription factor hsa:7040 TGFB1; transforming growth factor, beta 1

hsa05211 Renal cell carcinoma - Homo sapiens (human) (7)

hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:7040 TGFB1; transforming growth factor, beta 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04720 Long-term potentiation - Homo sapiens (human) (7)

cpd:C00575 3',5'-Cyclic AMP hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:468 ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04530 Tight junction - Homo sapiens (human) (7)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1460 CSNK2B; casein kinase 2, beta polypeptide (EC:2.7.11.1) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:4627 MYH9; myosin, heavy chain 9, non-muscle hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04940 Type I diabetes mellitus - Homo sapiens (human) (7)

hsa04970 Salivary secretion - Homo sapiens (human) (7)

cpd:C00575 3',5'-Cyclic AMP cpd:C00942 3',5'-Cyclic GMP hsa:1471 CST3; cystatin C hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:5542 PRB1; proline-rich protein BstNI subfamily 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) (7)

hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:867 CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04916 Melanogenesis - Homo sapiens (human) (7)

cpd:C00575 3',5'-Cyclic AMP hsa:10488 CREB3; cAMP responsive element binding protein 3 hsa:1385 CREB1; cAMP responsive element binding protein 1 hsa:1387 CREBBP; CREB binding protein (EC:2.3.1.48) hsa:2033 EP300; E1A binding protein p300 (EC:2.3.1.48) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) (6)

cpd:C00735 Cortisol cpd:C00788 L-Adrenaline cpd:C01516 Morphine cpd:C01829 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine hsa:2908 NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) hsa:7442 TRPV1; transient receptor potential cation channel, subfamily V, member 1

hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) (6)

hsa:2010 EMD; emerin hsa:3678 ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) hsa:3690 ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) hsa:4000 LMNA; lamin A/C hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1

hsa03022 Basal transcription factors - Homo sapiens (human) (6)

hsa:2959 GTF2B; general transcription factor IIB hsa:2965 GTF2H1; general transcription factor IIH, polypeptide 1, 62kDa hsa:2969 GTF2I; general transcription factor IIi hsa:6872 TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (EC:2.7.11.1) hsa:6878 TAF6; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa hsa:6880 TAF9; TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa (EC:2.7.4.3)

hsa00230 Purine metabolism - Homo sapiens (human) (6)

cpd:C00575 3',5'-Cyclic AMP cpd:C00942 3',5'-Cyclic GMP hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6) hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3) hsa:5422 POLA1; polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7)

hsa03450 Non-homologous end-joining - Homo sapiens (human) (6)

hsa:10111 RAD50; RAD50 homolog (S. cerevisiae) hsa:2547 XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6 hsa:4361 MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) hsa:5591 PRKDC; protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) hsa:7518 XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4 hsa:7520 XRCC5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

hsa03420 Nucleotide excision repair - Homo sapiens (human) (6)

hsa:2965 GTF2H1; general transcription factor IIH, polypeptide 1, 62kDa hsa:29935 RPA4; replication protein A4, 30kDa hsa:5111 PCNA; proliferating cell nuclear antigen hsa:6117 RPA1; replication protein A1, 70kDa hsa:6118 RPA2; replication protein A2, 32kDa hsa:6119 RPA3; replication protein A3, 14kDa

hsa03410 Base excision repair - Homo sapiens (human) (6)

hsa:142 PARP1; poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) hsa:3146 HMGB1; high mobility group box 1 hsa:328 APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1 (EC:4.2.99.18) hsa:3980 LIG3; ligase III, DNA, ATP-dependent (EC:6.5.1.1) hsa:5111 PCNA; proliferating cell nuclear antigen hsa:7515 XRCC1; X-ray repair complementing defective repair in Chinese hamster cells 1

hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) (6)

cpd:C00575 3',5'-Cyclic AMP cpd:C00951 Estradiol-17beta hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:2099 ESR1; estrogen receptor 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:8766 RAB11A; RAB11A, member RAS oncogene family

hsa04150 mTOR signaling pathway - Homo sapiens (human) (5)

hsa:1975 EIF4B; eukaryotic translation initiation factor 4B hsa:1977 EIF4E; eukaryotic translation initiation factor 4E hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:7249 TSC2; tuberous sclerosis 2

hsa05110 Vibrio cholerae infection - Homo sapiens (human) (5)

cpd:C00575 3',5'-Cyclic AMP hsa:375 ARF1; ADP-ribosylation factor 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1

hsa04370 VEGF signaling pathway - Homo sapiens (human) (5)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:572 BAD; BCL2-associated agonist of cell death hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human) (5)

hsa:10376 TUBA1B; tubulin, alpha 1b hsa:4691 NCL; nucleolin hsa:60 ACTB; actin, beta hsa:71 ACTG1; actin, gamma 1 hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05012 Parkinson's disease - Homo sapiens (human) (5)

hsa:292 SLC25A5; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 hsa:522 ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14) hsa:54205 CYCS; cytochrome c, somatic hsa:7332 UBE2L3; ubiquitin-conjugating enzyme E2L 3 (EC:6.3.2.19) hsa:836 CASP3; caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)

hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) (5)

hsa:1072 CFL1; cofilin 1 (non-muscle) hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa05219 Bladder cancer - Homo sapiens (human) (5)

hsa:1019 CDK4; cyclin-dependent kinase 4 (EC:2.7.11.22) hsa:1950 EGF; epidermal growth factor hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53

hsa05340 Primary immunodeficiency - Homo sapiens (human) (5)

hsa:3932 LCK; lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) hsa:57379 AICDA; activation-induced cytidine deaminase (EC:3.5.4.5) hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) hsa:8517 IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

hsa05310 Asthma - Homo sapiens (human) (5)

hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) (5)

cpd:C00187 Cholesterol cpd:C00410 Progesterone cpd:C00735 Cortisol cpd:C00951 Estradiol-17beta cpd:C02140 Corticosterone

hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) (5)

cpd:C00575 3',5'-Cyclic AMP cpd:C00942 3',5'-Cyclic GMP hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5499 PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04977 Vitamin digestion and absorption - Homo sapiens (human) (5)

cpd:C00187 Cholesterol cpd:C00473 Retinol cpd:C00681 1-Acyl-sn-glycerol 3-phosphate hsa:335 APOA1; apolipoprotein A-I hsa:338 APOB; apolipoprotein B (including Ag(x) antigen)

hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) (4)

hsa:10482 NXF1; nuclear RNA export factor 1 hsa:1460 CSNK2B; casein kinase 2, beta polypeptide (EC:2.7.11.1) hsa:6880 TAF9; TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa (EC:2.7.4.3) hsa:7514 XPO1; exportin 1 (CRM1 homolog, yeast)

hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) (4)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:2885 GRB2; growth factor receptor-bound protein 2 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24)

hsa04740 Olfactory transduction - Homo sapiens (human) (4)

cpd:C00575 3',5'-Cyclic AMP cpd:C00942 3',5'-Cyclic GMP hsa:409 ARRB2; arrestin, beta 2 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa00830 Retinol metabolism - Homo sapiens (human) (4)

cpd:C00473 Retinol cpd:C00777 Retinoate cpd:C15493 9-cis-Retinoic acid cpd:C16677 all-trans-4-Hydroxyretinoic acid

hsa04975 Fat digestion and absorption - Homo sapiens (human) (4)

cpd:C00187 Cholesterol cpd:C00681 1-Acyl-sn-glycerol 3-phosphate hsa:335 APOA1; apolipoprotein A-I hsa:338 APOB; apolipoprotein B (including Ag(x) antigen)

hsa04971 Gastric acid secretion - Homo sapiens (human) (4)

cpd:C00575 3',5'-Cyclic AMP hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) hsa:60 ACTB; actin, beta

hsa03320 PPAR signaling pathway - Homo sapiens (human) (4)

cpd:C15493 9-cis-Retinoic acid hsa:335 APOA1; apolipoprotein A-I hsa:336 APOA2; apolipoprotein A-II hsa:7316 UBC; ubiquitin C

hsa03050 Proteasome - Homo sapiens (human) (4)

hsa:3458 IFNG; interferon, gamma hsa:5683 PSMA2; proteasome (prosome, macropain) subunit, alpha type, 2 (EC:3.4.25.1) hsa:5684 PSMA3; proteasome (prosome, macropain) subunit, alpha type, 3 (EC:3.4.25.1) hsa:5688 PSMA7; proteasome (prosome, macropain) subunit, alpha type, 7 (EC:3.4.25.1)

hsa04930 Type II diabetes mellitus - Homo sapiens (human) (4)

hsa:3551 IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:5599 MAPK8; mitogen-activated protein kinase 8 (EC:2.7.11.24) hsa:8651 SOCS1; suppressor of cytokine signaling 1

hsa00240 Pyrimidine metabolism - Homo sapiens (human) (3)

hsa:4830 NME1; non-metastatic cells 1, protein (NM23A) expressed in (EC:2.7.4.6) hsa:4831 NME2; non-metastatic cells 2, protein (NM23B) expressed in (EC:2.7.4.6 2.7.13.3) hsa:5422 POLA1; polymerase (DNA directed), alpha 1, catalytic subunit (EC:2.7.7.7)

hsa04140 Regulation of autophagy - Homo sapiens (human) (3)

hsa:3439 IFNA1; interferon, alpha 1 hsa:3458 IFNG; interferon, gamma hsa:8678 BECN1; beclin 1, autophagy related

hsa04340 Hedgehog signaling pathway - Homo sapiens (human) (3)

cpd:C00187 Cholesterol hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04360 Axon guidance - Homo sapiens (human) (3)

hsa:1072 CFL1; cofilin 1 (non-muscle) hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:998 CDC42; cell division cycle 42 (GTP binding protein, 25kDa)

hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) (3)

cpd:C00575 3',5'-Cyclic AMP cpd:C00735 Cortisol hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153)

hsa04721 Synaptic vesicle cycle - Homo sapiens (human) (3)

hsa:1785 DNM2; dynamin 2 (EC:3.6.5.5) hsa:5864 RAB3A; RAB3A, member RAS oncogene family hsa:6616 SNAP25; synaptosomal-associated protein, 25kDa

hsa04710 Circadian rhythm - mammal - Homo sapiens (human) (3)

cpd:C00575 3',5'-Cyclic AMP hsa:406 ARNTL; aryl hydrocarbon receptor nuclear translocator-like hsa:9575 CLOCK; clock homolog (mouse) (EC:2.3.1.48)

hsa04742 Taste transduction - Homo sapiens (human) (3)

cpd:C00575 3',5'-Cyclic AMP cpd:C00942 3',5'-Cyclic GMP hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa04972 Pancreatic secretion - Homo sapiens (human) (3)

cpd:C00575 3',5'-Cyclic AMP hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:8766 RAB11A; RAB11A, member RAS oncogene family

hsa03015 mRNA surveillance pathway - Homo sapiens (human) (3)

hsa:10189 THOC4; THO complex 4 hsa:10482 NXF1; nuclear RNA export factor 1 hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1

hsa04730 Long-term depression - Homo sapiens (human) (3)

cpd:C00942 3',5'-Cyclic GMP hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)

hsa02010 ABC transporters - Homo sapiens (human) (3)

cpd:C00051 Glutathione hsa:6890 TAP1; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) hsa:6891 TAP2; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

hsa05217 Basal cell carcinoma - Homo sapiens (human) (3)

cpd:C00187 Cholesterol hsa:2932 GSK3B; glycogen synthase kinase 3 beta (EC:2.7.11.26) hsa:7157 TP53; tumor protein p53

hsa00350 Tyrosine metabolism - Homo sapiens (human) (3)

cpd:C00788 L-Adrenaline cpd:C01829 O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine hsa:4282 MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1)

hsa04724 Glutamatergic synapse - Homo sapiens (human) (3)

cpd:C00575 3',5'-Cyclic AMP hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5566 PRKACA; protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11)

hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human) (2)

hsa:2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00590 Arachidonic acid metabolism - Homo sapiens (human) (2)

hsa:5743 PTGS2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) hsa:6916 TBXAS1; thromboxane A synthase 1 (platelet) (EC:5.3.99.5)

hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) (2)

hsa:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153)

hsa00562 Inositol phosphate metabolism - Homo sapiens (human) (2)

hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153) hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa04744 Phototransduction - Homo sapiens (human) (2)

cpd:C00942 3',5'-Cyclic GMP hsa:409 ARRB2; arrestin, beta 2

hsa00330 Arginine and proline metabolism - Homo sapiens (human) (2)

hsa:4842 NOS1; nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39)

hsa04142 Lysosome - Homo sapiens (human) (2)

hsa:3482 IGF2R; insulin-like growth factor 2 receptor hsa:4074 M6PR; mannose-6-phosphate receptor (cation dependent)

hsa05216 Thyroid cancer - Homo sapiens (human) (2)

hsa:595 CCND1; cyclin D1 hsa:7157 TP53; tumor protein p53

hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) (2)

hsa:3708 ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 hsa:5290 PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide (EC:2.7.1.153)

hsa04146 Peroxisome - Homo sapiens (human) (2)

hsa:4843 NOS2; nitric oxide synthase 2, inducible (EC:1.14.13.39) hsa:5052 PRDX1; peroxiredoxin 1 (EC:1.11.1.15)

hsa04320 Dorso-ventral axis formation - Homo sapiens (human) (2)

hsa:1956 EGFR; epidermal growth factor receptor (EC:2.7.10.1) hsa:2885 GRB2; growth factor receptor-bound protein 2

hsa00983 Drug metabolism - other enzymes - Homo sapiens (human) (1)

hsa:3615 IMPDH2; IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205)

hsa00360 Phenylalanine metabolism - Homo sapiens (human) (1)

hsa:4282 MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1)

hsa03018 RNA degradation - Homo sapiens (human) (1)

hsa:26986 PABPC1; poly(A) binding protein, cytoplasmic 1

hsa04978 Mineral absorption - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa03010 Ribosome - Homo sapiens (human) (1)

hsa:6146 RPL22; ribosomal protein L22

hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) (1)

cpd:C00681 1-Acyl-sn-glycerol 3-phosphate

hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00270 Cysteine and methionine metabolism - Homo sapiens (human) (1)

cpd:C00051 Glutathione

hsa04974 Protein digestion and absorption - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00380 Tryptophan metabolism - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan
ec:1.13.11.11 tryptophan 2,3-dioxygenase; tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase
ec:1.13.11.52 indoleamine 2,3-dioxygenase; IDO (ambiguous); tryptophan pyrrolase (ambiguous)

hsa03060 Protein export - Homo sapiens (human) (1)

hsa:3309 HSPA5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) (1)

hsa:6616 SNAP25; synaptosomal-associated protein, 25kDa

hsa00480 Glutathione metabolism - Homo sapiens (human) (1)

cpd:C00051 Glutathione

hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) (1)

cpd:C01516 Morphine

hsa00051 Fructose and mannose metabolism - Homo sapiens (human) (1)

hsa:7167 TPI1; triosephosphate isomerase 1 (EC:5.3.1.1)

hsa00190 Oxidative phosphorylation - Homo sapiens (human) (1)

hsa:522 ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (EC:3.6.1.14)

hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) (1)

cpd:C00078 L-Tryptophan

hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) (1)

cpd:C00187 Cholesterol

hsa00100 Steroid biosynthesis - Homo sapiens (human) (1)

cpd:C00187 Cholesterol

hsa00980 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) (1)

cpd:C00745 Nicotine

hsa00561 Glycerolipid metabolism - Homo sapiens (human) (1)

cpd:C00681 1-Acyl-sn-glycerol 3-phosphate

MANY OF THE PROTEINS IN THIS NETWORK CAN BE FOUND IN ALZHEIMER'S DISEASE PLAQUES AND TANGLES suggesting that these structures, which also contain immune and complement related proteins, are cemeteries reflecting an immune battle between host and virus Neurochem Int 2010

Yellow gene products interact with Herpes simplex: Red compounds are also involved in the viral life cycle: see database ..............Click on "show all objects" for legends to figures

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