Polygenic Signaling Pathways

This site contains lists of genes and environmental risk factors positively associated with Alzheimer's disease, Bipolar disorder or Schizophrenia. The protein products of the genes form consecutive elements of a signaling cascade or metabolic pathway. They may bind to each other, control each others transcription or form functional microcomplexes. These pathways, etched out by multiple association studies, may underpin the pathology of each disease. These pathways may also be used by the environmental risk factors (viruses, bacteria and other) associated with the disease. Details of polymorphisms as well as negative/positive association data can be found via Useful links.

Carter, CJ: Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability Schiz. Res, 86, 1-14, 2006

...Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins and atherosclerosis. Neurochem. Int 50, 12-38, 2007

...Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: Implications for oligodendrocyte viability. Neurochem Int 50, 461-490

...EIF2B and oligodendrocyte vulnerability: Where nature and nurture meet in Bipolar disorder and schizophrenia ? Schiz Bull.33,1343-1353. 2007

...Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades.Neurochem Int EPUB 2008

The information provided on this site is for research purposes. It is designed to support, not to replace, the relationship that exists between a patient/site visitor and his/her physician. All email correspondence from this site will be treated in the strictest confidence. All visitors can read the information in this database, which is maintained and funded by the author and by the advertising on the site.

Throughout this site there are links to Entrez Gene and Pubmed (a service of the National Library of Medicine that includes over 16 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources) See disclaimer and copyright, as well as to OMIM(Online Mendelian Inheritance in Man, OMIM (TM). McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD).

Kegg pathway data is provided by the Kanehisa Laboratories (www.kegg.org). For Kegg licencing conditions, please contact Pathway solutions Inc(www.pathway.jp). Genecards data are with the permission of GeneCards.org. BIOCARTA pathway links are provided for some genes (see Terms and conditions) and Disclaimer. BioGrid links are from the Ontario Cancer Institute, Canada Stark et al, 2006.

Last Update: April 24, 2008